2. Gene
  3. Bax - BCL2 associated X, apoptosis regulator Gene

Bax - BCL2 associated X, apoptosis regulator Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：BCL2 相关 X，细胞凋亡调节因子

种属: Rattus norvegicus

基因 ID: 24887 | 基因类型: protein coding

关于 Bax

Primary_assembly 1: 95,938,808-95,945,368 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 204 orthologues, 13 paralogues and is associated with 97 phenotypes. Biased expression in Spleen (RPKM 111.1), Thymus (RPKM 15.) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 BH 域绑定活动；伴侣结合活动；和热激蛋白结合活性。参与多个过程，包括胶质细胞凋亡过程；线粒体组织；和对皮质酮的反应。位于胞质溶胶中；线粒体外膜；和细胞质的核周区。用于研究脑胶质瘤；子宫内膜异位症;吗啡依赖；和癌前病变。几种疾病的生物标志物，包括腹型肥胖-代谢综合征 1；动脉疾病（多发性）；脑部疾病（多种）；心脏病（多种）；和神经退行性疾病（多种）。该基因的人类直系同源物与急性淋巴细胞白血病有关；共济失调毛细血管扩张症;结肠腺癌；结直肠癌；和肺非小细胞癌。与人 Bax 同源（BCL2 相关 X，细胞凋亡调节剂）。 [由基因组资源联盟提供，2022 年 4 月]

Enables BH domain binding activity; chaperone binding activity; and heat shock protein binding activity. Involved in several processes, including glial cell apoptotic process; mitochondrion organization; and response to corticosterone. Located in cytosol; mitochondrial outer membrane; and perinuclear region of cytoplasm. Used to study brain glioma; endometriosis; morphine dependence; and pre-malignant neoplasm. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; artery disease (multiple); brain disease (multiple); heart disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; colorectal cancer; and lung non-small cell carcinoma. Orthologous to human Bax (BCL2 associated X, Apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]

Bax 基因产物(1)

mRNA Protein Name
NM_017059.2 NP_058755.2 apoptosis regulator BAX
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables BH domain binding IPI
IPI: 通过物理相互作用推断
9356461 RGD
enables heat shock protein binding IPI
IPI: 通过物理相互作用推断
12070120 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15004018 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
9356461 RGD
enables protein-folding chaperone binding IPI
IPI: 通过物理相互作用推断
12070120 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular respiration IDA
IDA: 通过直接分析推断
12460673 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: 通过表达模式推断
25726415 RGD
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
9813151 RGD
involved in glial cell apoptotic process IEP
IEP: 通过表达模式推断
18931364 RGD
involved in inner mitochondrial membrane organization IDA
IDA: 通过直接分析推断
12460673 RGD
involved in outer mitochondrial membrane organization IDA
IDA: 通过直接分析推断
12460673 RGD
involved in ovarian follicle development IEP
IEP: 通过表达模式推断
17570453 RGD
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
9804769 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
20385067 RGD
involved in release of cytochrome c from mitochondria IDA
IDA: 通过直接分析推断
10724126 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
17084983 RGD
involved in response to copper ion IEP
IEP: 通过表达模式推断
18289470 RGD
involved in response to corticosterone IEP
IEP: 通过表达模式推断
17562391 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
24089674 RGD
involved in response to ischemia IEP
IEP: 通过表达模式推断
31583047 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
17784886 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
10724126 RGD
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
15044178 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
11299004 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Bax 蛋白结构

bcl-2

bcl-2: TIGR00865 (12 - 191)

  • 0
  • 100
  • 192 a.a.
蛋白主名 其他名称

apoptosis regulator BAX

Bcl2-associated X protein

相关产品

Approval
生物活性分子 (6)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0402 Amantadine Modulator 99.90% 是
HY-B1192 Estradiol benzoate 99.89% 否
HY-B1357 Digitoxin 99.36% 是
HY-B0402A Amantadine hydrochloride Modulator ≥98.0% 是
HY-B0621 Triclabendazole 98.72% 是
HY-B0402B Amantadine sulfate Modulator / 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-13755 Sulforaphane Inhibitor 99.75% Phase 4
HY-13560 AVN-944 Modulator 99.77% Phase 2
Pre-clinical Phase
生物活性分子 (50)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-107202 Polyinosinic-polycytidylic acid 99.40% 否
HY-13594 Chlorin e6 98.31% 否
HY-103269 BAI1 Inhibitor 99.89% 否
HY-N0674 Dehydrocorydaline Modulator 99.77% 否
HY-P0081 Bax inhibitor peptide V5 Inhibitor 99.77% 否
HY-N0361 Dihydrocapsaicin Modulator 99.86% 否
HY-123054 BTSA1 Activator 99.49% 否
HY-13108 Bz 423 Activator 99.72% 否
HY-120079 MSN-125 Inhibitor 99.00% 否
HY-B1971 Deltamethrin 99.93% 否
HY-13755A (R)-Sulforaphane Inhibitor 99.48% 否
HY-N0060B (E)-Ferulic acid Activator 99.89% 否
HY-N6626 Pyraclostrobin 99.91% 否
HY-P1928 Humanin Inhibitor 99.83% 否
HY-N0831 Jaceosidin Activator 99.51% 否
HY-W082785A L6H21 Modulator 99.46% 否
HY-118948 MSN-50 Inhibitor 98.68% 否
HY-15341 BAM7 Activator 98.53% 否
HY-157176 BAX-IN-1 Inhibitor ≥98.0% 否
HY-108164 Aspidin BB Modulator 98.08% 否
HY-132173 GL0388 Activator 98.01% 否
HY-122760 Bax activator-1 Activator 98.45% 否
HY-N1157 Thevetiaflavone Modulator ≥98.0% 否
HY-N9802 n-Butyl-β-D-fructofuranoside Activator ≥97.0% 否
HY-N0905 Ginsenoside Rh4 Activator 99.28% 否
HY-144791 Bcl-2-IN-6 Modulator / 否
HY-148368 CYD-4-61 Activator / 否
HY-144792 Bcl-2-IN-7 Modulator / 否
HY-N0831R Jaceosidin (Standard) Activator / 否
HY-101996 SMBA1 Agonist / 否
HY-117652 Lobetyol Modulator / 否
HY-151429 Antitumor agent-77 Inhibitor / 否
HY-N10313 Dehydrobruceine B Modulator / 否
HY-150540 Bcl-2-IN-10 Inhibitor / 否
HY-N10481 Aviculin Modulator / 否
HY-146105 Anticancer agent 65 Modulator / 否
HY-162360 EGFR-IN-109 Inhibitor / 否
HY-143235 BRD4 Inhibitor-15 Modulator / 否
HY-168623 EGFR-IN-134 Inhibitor / 否
HY-161659 Apoptosis inducer 19 Modulator / 否
HY-147929 Apoptotic agent-3 Activator / 否
HY-147928 Apoptotic agent-2 Activator / 否
HY-147889 BBR-BODIPY Activator 98.15% 否
HY-P3148 Astin B Modulator / 否
HY-151428 Antitumor agent-78 Inhibitor / 否
HY-147514 Anticancer agent 64 Modulator / 否
HY-146253 CDK1/2/4-IN-1 Activator / 否
HY-146548 Anticancer agent 43 Inducer 98.58% 否
HY-122481 Thaspine acetate / 否
HY-119682 Bax agonist 1 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bax NCBI NCBI:581
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