LSM1 - LSM1 homolog, mRNA degradation associated Gene

中文名称：LSM1 同源物，mRNA 降解相关

种属: Homo sapiens

同用名: CASM; YJL124C

基因 ID: 27257 | 基因类型: protein coding

关于 LSM1

Cytogenetic location: 8p11.23 Genomic coordinates (GRCh38): 8:38,163,321-38,176,730 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 16.1), placenta (RPKM 14.6) and 25 other tissues.

功能概要

该基因编码 RNA 结合蛋白 LSm 家族的成员。 LSm 蛋白形成稳定的异聚体，特异性结合 U6 snRNA 的 3'-末端寡核苷酸 (U) 束，并可能通过介导 U4/U6 snRNP 形成在 pre-mRNA 剪接中发挥作用。该基因表达增加可能在细胞转化和多种恶性肿瘤 (包括肺癌、间皮瘤和乳腺癌) 的进展中发挥作用。已观察到该基因的选择性剪接转录变体，该基因的假基因位于 9 号染色体的短臂上。[RefSeq 提供，2011 年 11 月]

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung Cancer, mesothelioma and breast Cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]

LSM1 基因产物(1)

mRNA	Protein	Name
NM_014462.3	NP_055277.1	U6 snRNA-associated Sm-like protein LSm1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	14667819	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in histone mRNA catabolic process	IMP IMP: 通过突变表型推断	18172165	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	18559850	GOA
located in nucleus	IDA IDA: 通过直接分析推断	18559850	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LSM1 蛋白结构

LSM

0
100
133 a.a.

蛋白主名

其他名称

U6 snRNA-associated Sm-like protein LSm1

LSM1 homolog, U6 small nuclear RNA associated

LSM1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LSM1	O15116	COMT	Homo sapiens	P21964-2	Y2H Pooling	32814053
种属内	LSM1	O15116	COMT	Homo sapiens	P21964-2	Validated Y2H	32814053
种属内	LSM1	O15116	COMT	Homo sapiens	P21964-2	Y2H Array	32814053
种属内	LSM1	O15116	BEX5	Homo sapiens	Q5H9J7	Validated Y2H	32296183
种属内	LSM1	O15116	BEX5	Homo sapiens	Q5H9J7	Y2H Array	32296183
种属内	LSM1	O15116	BEX5	Homo sapiens	Q5H9J7	Y2H Prey Pooling	32296183
种属内	LSM1	O15116	MCCD1	Homo sapiens	P59942	Validated Y2H	32296183
种属内	LSM1	O15116	MCCD1	Homo sapiens	P59942	Y2H Array	32296183
种属内	LSM1	O15116	MCCD1	Homo sapiens	P59942	Y2H Prey Pooling	32296183
种属内	LSM1	O15116	DAPL1	Homo sapiens	A0PJW8	Y2H Prey Pooling	32296183
种属内	LSM1	O15116	DAPL1	Homo sapiens	A0PJW8	Y2H Array	32296183
种属内	LSM1	O15116	PATL1	Homo sapiens	Q86TB9	Anti Tag CoIP	33961781
种属内	LSM1	O15116	PATL1	Homo sapiens	Q86TB9	Validated Y2H	32296183
种属内	LSM1	O15116	LSM2	Homo sapiens	Q9Y333	Y2H Prey Pooling	32296183
种属内	LSM1	O15116	LSM2	Homo sapiens	Q9Y333	GMS	19628699
种属内	LSM1	O15116	LSM2	Homo sapiens	Q9Y333	Ion Exchange Chrom	19628699
种属内	LSM1	O15116	LSM2	Homo sapiens	Q9Y333	Validated Y2H	32296183
种属内	LSM1	O15116	LSM2	Homo sapiens	Q9Y333	Y2H	15231747
种属内	LSM1	O15116	LSM2	Homo sapiens	Q9Y333	Y2H Array	32296183
种属内	LSM1	O15116	LSM2	Homo sapiens	Q9Y333	Anti Tag CoIP	33961781
种属内	LSM1	O15116	LSM3	Homo sapiens	P62310	Y2H Prey Pooling	25416956
种属内	LSM1	O15116	LSM3	Homo sapiens	P62310	Ion Exchange Chrom	19628699
种属内	LSM1	O15116	LSM3	Homo sapiens	P62310	Y2H Array	26871637
种属内	LSM1	O15116	LSM3	Homo sapiens	P62310	Y2H	15231747
种属内	LSM1	O15116	LSM3	Homo sapiens	P62310	GMS	19628699
种属内	LSM1	O15116	LSM3	Homo sapiens	P62310	Validated Y2H	25416956
种属内	LSM1	O15116	LSM3	Homo sapiens	P62310	Validated Y2H	26871637
种属内	LSM1	O15116	LSM3	Homo sapiens	P62310	Validated Y2H	32296183
种属内	LSM1	O15116	LSM3	Homo sapiens	P62310	Y2H Prey Pooling	26871637
种属内	LSM1	O15116	PSMB5	Homo sapiens	P28074	Validated Y2H	32296183
种属内	LSM1	O15116	PSMB5	Homo sapiens	P28074	Y2H	15231747
种属内	LSM1	O15116	PSMB8	Homo sapiens	P28062-2	Validated Y2H	32296183
种属内	LSM1	O15116	LSM4	Homo sapiens	Q9Y4Z0	Anti Tag CoIP	33961781
种属内	LSM1	O15116	LSM4	Homo sapiens	Q9Y4Z0	MAPPIT	25416956
种属内	LSM1	O15116	LSM4	Homo sapiens	Q9Y4Z0	GMS	19628699
种属内	LSM1	O15116	LSM4	Homo sapiens	Q9Y4Z0	Y2H	15231747
种属内	LSM1	O15116	LSM4	Homo sapiens	Q9Y4Z0	Ion Exchange Chrom	19628699
种属内	LSM1	O15116	LSM6	Homo sapiens	P62312	GMS	19628699
种属内	LSM1	O15116	LSM6	Homo sapiens	P62312	Anti Tag CoIP	33961781
种属内	LSM1	O15116	LSM6	Homo sapiens	P62312	Ion Exchange Chrom	19628699
种属内	LSM1	O15116	AGR3	Homo sapiens	Q8TD06	Validated Y2H	32296183
种属内	LSM1	O15116	AGR2	Homo sapiens	O95994	Validated Y2H	32296183
种属内	LSM1	O15116	TCL1B	Homo sapiens	O95988	Y2H Prey Pooling	32296183
种属内	LSM1	O15116	TCL1B	Homo sapiens	O95988	Validated Y2H	32296183
种属内	LSM1	O15116	TCL1B	Homo sapiens	O95988	Y2H Array	32296183
种属内	LSM1	O15116	GSTA4	Homo sapiens	O15217	Y2H Array	32296183
种属内	LSM1	O15116	GSTA4	Homo sapiens	O15217	Y2H Prey Pooling	32296183
种属内	LSM1	O15116	GSTA4	Homo sapiens	O15217	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LSM1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70198	LSM1 Protein, Human (His)	O15116 (M1-Y133)	≥95%

关联疾病

疾病名称

别名

Non-Functioning Pancreatic Endocrine Tumor

Non Functioning Pancreatic Endocrine Tumor	Non-Functioning Epts
Non-Functioning Endocrine Pancreatic Tumors

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07852	LSM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	LSM1	MGD	MGI:1914457
Rattus norvegicus	LSM1	RGD	RGD:1304967
Felis catus	LSM1	VGNC	VGNC:107342
Canis familiaris	LSM1	VGNC	VGNC:42838
Bos taurus	LSM1	VGNC	VGNC:31050
Others	LSM1	NCBI

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