2. Gene
  3. Nlrp3 - NLR family, pyrin domain containing 3 Gene

Nlrp3 - NLR family, pyrin domain containing 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：NLR 家族，含 pyrin 结构域 3

种属: Rattus norvegicus

同用名: Cias1

基因 ID: 287362 | 基因类型: protein coding

关于 Nlrp3

Primary_assembly 10: 44,328,566-44,352,811 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 87 orthologues, 21 paralogues and is associated with 32 phenotypes. Biased expression in Spleen (RPKM 82.9), Lung (RPKM 27.1) and 8 other tissues.

功能概要

预测该基因编码的蛋白可启动DNA结合转录因子结合活性；相同的蛋白质结合活性；和序列特异性 DNA 结合活性。参与参与炎症反应的白细胞迁移；对乙醇的反应；对有机环状化合物的反应。预测位于高尔基体膜和细胞核内。预计是 NLRP3 炎性体复合体的一部分。酒精性肝炎的生物标志物。该基因的人类直系同源物与 CINCA 综合征有关； Muckle-Wells 综合症；常染色体显性非综合征性耳聋 34；家族性寒冷自身炎症综合征 1；和荨麻疹。与人类 NLRP3 同源（NLR 家族 pyrin 结构域包含 3）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA-binding transcription factor binding activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in leukocyte migration involved in inflammatory response; response to ethanol; and response to organic cyclic compound. Predicted to be located in Golgi membrane and nucleus. Predicted to be part of NLRP3 inflammasome complex. Biomarker of alcoholic hepatitis. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Nlrp3 基因产物(1)

mRNA Protein Name
NM_001191642.1 NP_001178571.1 NACHT, LRR and PYD domains-containing protein 3
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in leukocyte migration involved in inflammatory response IEP
IEP: 通过表达模式推断
27939985 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
27939985 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
27939985 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Nlrp3 蛋白结构

Pyrin_NALPs

Pyrin_NALPs: cd08320 (9 - 89)

FISNA

FISNA: pfam14484 (137 - 207)

NACHT

NACHT: pfam05729 (217 - 386)

NOD2_WH

NOD2_WH: pfam17779 (461 - 517)

LRR_RI

LRR_RI: cd00116 (574 - 951)

LRR_RI

LRR_RI: sd00033 (741 - 769)

LRR_RI

LRR_RI: sd00033 (770 - 797)

LRR_RI

LRR_RI: sd00033 (798 - 826)

LRR_RI

LRR_RI: sd00033 (827 - 854)

LRR_RI

LRR_RI: sd00033 (855 - 883)

LRR_RI

LRR_RI: sd00033 (884 - 911)

LRR_RI

LRR_RI: sd00033 (912 - 936)

LRR_RI

LRR_RI: sd00033 (941 - 968)

LRR_RI

LRR_RI: smart00368 (966 - 993)

LRR_RI

LRR_RI: sd00033 (969 - 993)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1035 a.a.
蛋白主名 其他名称

NACHT, LRR and PYD domains-containing protein 3

PYRIN-containing APAF1-like protein 1

cold autoinflammatory syndrome 1 homolog

cold autoinflammatory syndrome 1 protein homolog

cryopyrin

mast cell maturation-associated-inducible protein 1

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0116 Stavudine Inhibitor 99.87% 是
HY-16059 Arglabin Inhibitor 99.87% 否
HY-B0516 Articaine hydrochloride Activator 99.38% 否
HY-B0516A Articaine Inhibitor / 否
HY-B0116A Stavudine sodium Inhibitor / 否
Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-17629 Dapansutrile Inhibitor ≥98.0% Phase 3
HY-156034 JT001 Inhibitor / Phase 3
HY-156034A JT001 sodium Inhibitor / Phase 3
HY-139396 BMS-986299 Agonist 99.76% Phase 1
HY-132831 Selnoflast Inhibitor 98.58% Phase 1
Pre-clinical Phase
生物活性分子 (66)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100381 Nigericin sodium salt Activator 99.37% 否
HY-12815A MCC950 sodium Inhibitor 99.75% 否
HY-12815 MCC950 Inhibitor 99.62% 否
HY-127019 Nigericin Activator 99.37% 否
HY-103666 CY-09 Inhibitor 98.01% 否
HY-101092 QS-21 Activator 99.67% 否
HY-116084 Trimethylamine N-oxide Activator ≥98.0% 否
HY-144226 NLRP3/AIM2-IN-3 Inhibitor 98.23% 否
HY-N0633 Muscone Inhibitor ≥98.0% 否
HY-156798 ADS032 Inhibitor 99.74% 否
HY-N0496 Ruscogenin Inhibitor 99.59% 否
HY-N0373 Licochalcone B Inhibitor 99.93% 否
HY-108915 Trimethylamine N-oxide dihydrate Activator ≥98.0% 否
HY-100581 CORM-3 Inhibitor ≥97.0% 否
HY-152670 JC2-11 Inhibitor 98.02% 否
HY-130252 YQ128 Inhibitor 99.83% 否
HY-N3005 Britannin Inhibitor 99.93% 否
HY-150206 NLRP3-IN-13 Inhibitor 99.01% 否
HY-N2485 4'-Methoxyresveratrol Activator 99.48% 否
HY-122920 Soyasaponin II Inhibitor 99.81% 否
HY-N0743 Senkyunolide A Inhibitor 99.92% 否
HY-137245 Emlenoflast Inhibitor 98.19% 否
HY-W082785A L6H21 Inhibitor 99.46% 否
HY-130494 (±)11(12)-EET Inhibitor 98.3% 否
HY-137245A Emlenoflast sodium Inhibitor 98.76% 否
HY-155876 NVP-DFV890 Antagonist 98.47% 否
HY-164304 INF 195 Inhibitor 99.55% 否
HY-137888A Oxidized ATP trisodium salt Inhibitor ≥98.0% 否
HY-155751 HMGB1-IN-1 Inhibitor 99.37% 否
HY-153554 NLRP3-IN-18 Inhibitor 98.06% 否
HY-N3242 Moronic acid Inhibitor 98.6% 否
HY-163159 NP3-562 Inhibitor 98.16% 否
HY-148187 NLRP3-IN-11 Inhibitor 98.79% 否
HY-162333 BAL-0028 Inhibitor 97.20% 否
HY-153261 NLRP3-IN-17 Inhibitor 99.23% 否
HY-163358 SLC3037 Inhibitor 99.85% 否
HY-117432 JC-171 Inhibitor 98.41% 否
HY-121988 INF4E Inhibitor 99.38% 否
HY-131040 NLRP3-IN-NBC6 Inhibitor 99.40% 否
HY-161297 NT-0249 Inhibitor / 否
HY-150965 NDT-30805 Inhibitor / 否
HY-132892 NLRP3-IN-4 Inhibitor / 否
HY-168594 α-Glucosidase/NLRP3-IN-1 Inhibitor / 否
HY-159482 SBN-284 Inhibitor / 否
HY-145910 NLRP3-IN-6 Inhibitor / 否
HY-168264 MC1 Inhibitor / 否
HY-161727 P2Y14R antagonist 1 Inhibitor / 否
HY-149122 NLRP3-IN-15 Inhibitor / 否
HY-163494 NLRP3-IN-36 Inhibitor / 否
HY-169227 NLRP3-IN-55 Inhibitor / 否
HY-149123 NLRP3-IN-16 Inhibitor / 否
HY-162588 MC-ND-18 Degrader / 否
HY-169188 NLRP3-IN-50 Inhibitor / 否
HY-145087 NP3-146 Inhibitor / 否
HY-163497 NLRP3-IN-38 Inhibitor / 否
HY-163695 NLRP3-IN-41 Inhibitor / 否
HY-145911 NLRP3-IN-7 Inhibitor / 否
HY-146765 AMS-17 Inhibitor / 否
HY-161329 NLRP3-IN-32 Inhibitor / 否
HY-149121 NLRP3-IN-14 Inhibitor / 否
HY-146594 NLRP3-IN-8 Inhibitor / 否
HY-159898 AChE/BChE-IN-23 Inhibitor / 否
HY-149087 MR2938 Inhibitor / 否
HY-146802 NLRP3-IN-9 Inhibitor / 否
HY-168009 NLRP3-IN-45 Inhibitor / 否
HY-163744 NLRP3-IN-42 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nlrp3 NCBI NCBI:114548
Mus musculus Nlrp3 NCBI NCBI:216799
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