2. Gene
  3. NEDD8 - NEDD8 ubiquitin like modifier Gene

NEDD8 - NEDD8 ubiquitin like modifier Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NEDD8 泛素样修饰因子

种属: Homo sapiens

同用名: NEDD-8

基因 ID: 4738 | 基因类型: protein coding

关于 NEDD8

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,216,857-24,232,367 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 217 orthologues and 10 paralogues. Ubiquitous expression in fat (RPKM 81.8), kidney (RPKM 81.6) and 25 other tissues.

功能概要

启用泛素蛋白连接酶结合活性。在蛋白质 neddylation 的上游或内部起作用。位于细胞质和核质中。帕金森病和恶性星形细胞瘤的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Enables ubiquitin protein Ligase binding activity. Acts upstream of or within protein neddylation. Located in cytosol and nucleoplasm. Biomarker of Parkinson's disease and malignant astrocytoma. [provided by Alliance of Genome Resources, Apr 2022]

NEDD8 基因产物(1)

mRNA Protein Name
NM_006156.3 NP_006147.1 NEDD8

NEDD8 蛋白结构

ubiquitin

ubiquitin: Ubiquitin family (6 - 74)

  • 0
  • 81 a.a.
蛋白主名 其他名称

NEDD8

neddylin

重组 NEDD8 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70843 NEDD8 Protein, Human Q15843 (M1-G76) ≥95%

关联疾病

疾病名称 别名
Malignant Astrocytoma

Astrocytic Tumor

Astrocytoma Of Brain

Astrocytoma Of Cerebrum

Astroglioma

Cerebral Astrocytoma

Astrocytoma
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-70062 Pevonedistat Inhibitor 99.98% Phase 3
HY-10484 Pevonedistat hydrochloride Inhibitor 99.19% Phase 3
HY-128586 TAS4464 Inhibitor 99.52% Phase 2
HY-128586A TAS4464 hydrochloride Inhibitor 98.12% Phase 1
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108702 ML-792 Inhibitor 99.90% 否
HY-101790A ZM223 hydrochloride Inhibitor 99.21% 否
HY-115537 NAE-IN-M22 Activator 99.94% 否
HY-101790 ZM223 Inhibitor / 否
HY-163105 Tubulin/NEDDylation-IN-1 Inhibitor 98.03% 否
HY-159601 CSN5-IN-1 Inhibitor / 否
HY-RS09181 NEDD8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus NEDD8 VGNC VGNC:80899
Mus musculus NEDD8 MGD MGI:97301
Canis familiaris NEDD8 VGNC VGNC:56061
Rattus norvegicus NEDD8 RGD RGD:3158
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