PEG3 - paternally expressed 3 Gene

中文名称：父系表达 3

种属: Homo sapiens

同用名: PW1; ZNF904; ZSCAN24; ZKSCAN22

关于 PEG3

功能概要

在人类中，ZIM2 和 PEG3 被视为两个不同的基因，尽管它们共享多个 5' 外显子和一个共同的启动子，并且两个基因都是父系表达的 (PMID:15203203) 。选择性剪接事件将它们共享的 5' 外显子与 ZIM2 独有的其余 4 个外显子或与 PEG3 独有的其余 2 个外显子连接起来。相反，在其他哺乳动物中，ZIM2 不进行印记，并且在小鼠、牛和可能的其他哺乳动物中，ZIM2 和 PEG3 基因不共享外显子。人 PEG3 蛋白属于 Kruppel C2H2 型锌指蛋白家族。 PEG3 可能在细胞增殖和 p53 介导的细胞凋亡中发挥作用。 PEG3 还在胶质瘤和卵巢细胞中显示出肿瘤抑制活性和肿瘤发生。该 PEG3 基因的可变剪接导致编码不同亚型的多个转录变体。[RefSeq 提供，2009 年 9 月]

In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated Apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]