PFDN5 - prefoldin subunit 5 Gene

中文名称：前折叠蛋白亚基 5

种属: Homo sapiens

同用名: MM1; MM-1; PFD5

关于 PFDN5

功能概要

该基因编码 prefoldin α 亚基家族的一个成员。编码的蛋白质是 prefoldin 的六个亚基之一，prefoldin 是一种分子伴侣复合物，可结合并稳定新合成的多肽，从而使它们能够正确折叠。该复合体由两个 alpha 和四个 beta 亚基组成，形成一个带有六个突出的卷曲螺旋的双 beta 桶组件。编码的蛋白质还可以抑制原癌基因 c-Myc 的转录活性。已经描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]