MTPAP - mitochondrial poly(A) polymerase Gene

中文名称：线粒体聚 (A) 聚合酶

种属: Homo sapiens

同用名: PAPD1; SPAX4; TENT6

基因 ID: 55149 | 基因类型: protein coding

关于 MTPAP

Cytogenetic location: 10p11.23 Genomic coordinates (GRCh38): 10:30,309,801-30,349,278 (from NCBI)

This gene has 5 transcripts (splice variants), 206 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 4.8), testis (RPKM 4.4) and 25 other tissues.

功能概要

该基因编码的蛋白质是类 DNA 聚合酶 B 型家族的成员。这种酶合成线粒体转录物的 3' poly (A) 尾巴，并在复制依赖性组蛋白 mRNA 降解中发挥作用。[RefSeq 提供，2011 年 1 月]

The protein encoded by this gene is a member of the DNA Polymerase type-B-like family. This Enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011]

MTPAP 基因产物(1)

mRNA	Protein	Name
NM_018109.4	NP_060579.3	poly(A) RNA polymerase, mitochondrial precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	21292163	GOA
enables UTP binding	IDA IDA: 通过直接分析推断	21292163	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	21292163	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	21292163	GOA
enables manganese ion binding	IDA IDA: 通过直接分析推断	21292163	GOA
enables poly(A) RNA polymerase activity	IDA IDA: 通过直接分析推断	21292163	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21903422	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	21292163	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in histone mRNA catabolic process	IMP IMP: 通过突变表型推断	18172165	GOA
involved in mitochondrial RNA 3'-end processing	IDA IDA: 通过直接分析推断	21292163	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MTPAP 蛋白结构

PAP_assoc

0
100
200
300
400
500
582 a.a.

蛋白主名

其他名称

poly(A) RNA polymerase, mitochondrial

PAP-associated domain-containing protein 1

MTPAP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MTPAP	Q9NVV4	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	21903422
Intra	MTPAP	Q9NVV4	CALCOCO2	Homo sapiens	Q13137	Anti Tag CoIP	21903422
Intra	MTPAP	Q9NVV4	GTF2IRD1	Homo sapiens	Q9UHL9	Anti Tag CoIP	33961781
Cross	MTPAP	Q9NVV4	Azi2	Mus musculus	Q9QYP6	Anti Tag CoIP	21903422
Intra	MTPAP	Q9NVV4	MTPAP	Homo sapiens	Q9NVV4	X-Ray Diffraction	21292163
Intra	MTPAP	Q9NVV4	EPS15	Homo sapiens	P42566	Phage Display	39009827
Intra	MTPAP	Q9NVV4	MTPAP	Homo sapiens	Q9NVV4	Light Scattering	21292163
Intra	MTPAP	Q9NVV4	MTPAP	Homo sapiens	Q9NVV4	GMS	21292163

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Spastic Ataxia 4, Autosomal Recessive

SPAX4	Autosomal Recessive Spastic Ataxia Type 4
Autosomal Recessive Spastic Ataxia-Optic Atrophy-Dysarthria Syndrome	Autosomal Recessive Spastic Ataxia 4
Autosomal Recessive Spastic Ataxia - Optic Atrophy - Dysarthria	Ataxia, Spastic, 4, Autosomal Recessive

Spastic Ataxia 4

Spastic Ataxia

Spax	Ataxia, Spastic

Spinal Muscular Atrophy, Distal, Autosomal Recessive, 2

Spinal Muscular Atrophy, Jerash Type	DSMA2
Neuropathy, Distal Hereditary Motor, Jerash Type	Hmnj
Autosomal Recessive Distal Spinal Muscular Atrophy 2	Neuronopathy, Distal Hereditary Motor, Jerash Type
Distal Spinal Muscular Atrophy 2	Dhmnj
Hereditary Motor Neuropathy, Jerash Type	Motor Neuropathy, Distal, Jerash Type
Distal Hereditary Motor Neuropathy, Jerash Type	Distal Hereditary Motor Neuropathy Jerash Type
Spinal Muscular Atrophy Jerash Type	Mndj
Autosomal Recessive Distal Spinal Muscular Atrophy Type 2	Distal Spinal Muscular Atrophy, Autosomal Recessive, 2
Atrophy, Muscular, Spinal, Distal, Autosomal Recessive, Type 2

Mitochondrial Dna Depletion Syndrome 13

MTDPS13	Fbxl4 Deficiency
Fbxl4-Related Encephalomyopathic Mitochondrial Dna Depletion Syndrome	Mitochondrial Dna Depletion Syndrome 13, Encephalomyopathic Type
Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form With Variable Craniofacial Anomalies	Mtdna Depletion Syndrome, Encephalomyopathic Form With Variable Craniofacial Anomalies
Fbxl4-Related Early-Onset Mitochondrial Encephalopathy	Mitochondrial Dna Depletion Syndrome 13 , Encephalomyopathic Type
Bxl4-Related Early-Onset Mitochondrial Encephalopathy	Encephalomyopathic Mitochondrial Dna Depletion Syndrome-13
Fbxl4-Related Early Onset Mitochondrial Encephalopathy	Mitochondrial Dna Depletion Syndrome, Type 13

Mitochondrial Dna Depletion Syndrome 3

Deoxyguanosine Kinase Deficiency	Mitochondrial Dna Depletion Syndrome, Hepatocerebral Form
MTDPS3	Dguok Deficiency
Dguok-Related Mitochondrial Dna Depletion Syndrome, Hepatocerebral Form	Dguok-Related Mitochondrial Dna Depletion Syndrome
Hepatocerebral Mitochondrial Dna Depletion Syndrome	Mtdna Depletion Syndrome, Hepatocerebral Form
Mitochondrial Dna Depletion Syndrome, Hepatocerebral Form Due To Dguok Deficiency	Hepatocerebral Mitochondrial Dna Deletions Syndrome Autosomal Recessive
Mitochondrial Dna Depletion Syndrome 3 Hepatocerebral Type	Mitochondrial Dna Depletion Syndrome , Type 3

Spastic Paraparesis

Perlman Syndrome

Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor	PRLMNS
Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism	Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor
Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor	Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor
Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism	Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome
Renal Hamartomas Nephroblastomatosis And Fetal Gigantism	Nephroblastoma
Fetal Macrosomia

Developmental And Epileptic Encephalopathy 2

Epileptic Encephalopathy, Early Infantile, 2	DEE2
Eiee2	Issx2
Developmental And Epileptic Encephalopathy, 2	Infantile Spasm Syndrome, X-Linked 2
Early Infantile Epileptic Encephalopathy 2	X-Linked Infantile Spasm Syndrome 2
Atypical Rett Syndrome Cdkl5-Related	Atypical Rett Syndrome Hanefeld Variant
Infantile Spasm Syndrome X-Linked 2	Rett Syndrome Early-Onset Seizure Variant
Rett Syndrome Variant With Infantile Spasms	Encephalopathy, Epileptic, Early Infantile, Type 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08813	MTPAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MTPAP	RGD	RGD:1310900
Bos taurus	MTPAP	VGNC	VGNC:57009
Macaca mulatta	MTPAP	VGNC	VGNC:106077
Mus musculus	MTPAP	MGD	MGI:1914690
Canis familiaris	MTPAP	VGNC	VGNC:52146

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MTPAP - mitochondrial poly(A) polymerase Gene

关于 MTPAP

功能概要

MTPAP 基因产物(1)

MTPAP 蛋白结构

MTPAP 蛋白互作信息

关联疾病

直系同源

热门区域

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MTPAP - mitochondrial poly(A) polymerase Gene

关于 MTPAP

功能概要

MTPAP 基因产物(1)

MTPAP 蛋白结构

MTPAP 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z