2. Gene
  3. PRKAA1 - protein kinase AMP-activated catalytic subunit alpha 1 Gene

PRKAA1 - protein kinase AMP-activated catalytic subunit alpha 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 AMP 激活的催化亚基 alpha 1

种属: Homo sapiens

同用名: AMPK; AMPKa1; AMPK alpha 1

基因 ID: 5562 | 基因类型: protein coding

关于 PRKAA1

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:40,759,389-40,798,374 (from NCBI)

This gene has 9 transcripts (splice variants), 229 orthologues and 17 paralogues. Ubiquitous expression in gall bladder (RPKM 18.4), thyroid (RPKM 16.3) and 25 other tissues.

功能概要

该基因编码的蛋白质属于 ser/thr 蛋白激酶家族。它是 5'-prime-AMP 活化蛋白激酶 (AMPK) 的催化亚基。 AMPK 是一种保存在所有真核细胞中的细胞能量感受器。 AMPK 的激酶活性由增加细胞 AMP/ATP 比率的刺激物激活。 AMPK 通过磷酸化调节许多关键代谢酶的活性。它通过关闭消耗 ATP 的生物合成途径来保护细胞免受导致 ATP 耗尽的压力。已经观察到编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic Enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

PRKAA1 基因产物(8)

mRNA Protein Name
NM_001355028.2 NP_001341957.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 3
NM_001355029.2 NP_001341958.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 4
NM_001355034.2 NP_001341963.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 5
NM_001355035.2 NP_001341964.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 6
NM_001355036.2 NP_001341965.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 6
NM_001355037.2 NP_001341966.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 6
NM_006251.6 NP_006242.5 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1
NM_206907.4 NP_996790.3 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables AMP-activated protein kinase activity IDA
IDA: 通过直接分析推断
14651849 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16306228 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
17028174 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18439900 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in CAMKK-AMPK signaling cascade IMP
IMP: 通过突变表型推断
26103054 GOA
involved in cellular response to glucose starvation IDA
IDA: 通过直接分析推断
14651849 GOA
involved in cellular response to nutrient levels IDA
IDA: 通过直接分析推断
25412657 GOA
involved in cellular response to stress IDA
IDA: 通过直接分析推断
37079666 GOA
acts upstream of positive effect lipid droplet disassembly IDA
IDA: 通过直接分析推断
34077757 GOA
involved in motor behavior IGI
IGI: 通过遗传相互作用推断
21768291 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
14651849 GOA
involved in negative regulation of hepatocyte apoptotic process IDA
IDA: 通过直接分析推断
32029622 GOA
involved in neuron cellular homeostasis IGI
IGI: 通过遗传相互作用推断
21768291 GOA
involved in positive regulation of T cell activation IDA
IDA: 通过直接分析推断
38377992 GOA
involved in positive regulation of T cell mediated immune response to tumor cell IDA
IDA: 通过直接分析推断
38377992 GOA
involved in positive regulation of autophagy IDA
IDA: 通过直接分析推断
22012985 GOA
involved in positive regulation of autophagy IMP
IMP: 通过突变表型推断
26103054 GOA
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
17028174 GOA
involved in protein localization to lipid droplet IDA
IDA: 通过直接分析推断
34077757 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
17028174 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
18381428 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
21768291 GOA
part of nucleotide-activated protein kinase complex IPI
IPI: 通过物理相互作用推断
25412657 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRKAA1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (28 - 279)

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  • 559 a.a.
蛋白主名 其他名称

5'-AMP-activated protein kinase catalytic subunit alpha-1

5'-AMP-activated protein kinase, catalytic alpha-1 chain

PRKAA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PRKAA1 Q13131 PNMA5 Homo sapiens Q96PV4
Y2H Array
25416956
种属内
PRKAA1 Q13131 PNMA5 Homo sapiens Q96PV4
Y2H Array
31515488
种属内
PRKAA1 Q13131 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
种属内
PRKAA1 Q13131 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
种属内
PRKAA1 Q13131 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
种属内
PRKAA1 Q13131 CDX4 Homo sapiens O14627
Validated Y2H
25416956
种属内
PRKAA1 Q13131 CDX4 Homo sapiens O14627
Y2H Array
25416956
种属内
PRKAA1 Q13131 CDX4 Homo sapiens O14627
Y2H Prey Pooling
25416956
种属内
PRKAA1 Q13131 RIMBP3 Homo sapiens Q9UFD9
Y2H Prey Pooling
25416956
种属内
PRKAA1 Q13131 RIMBP3 Homo sapiens Q9UFD9
Y2H Array
25416956
种属内
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Y2H Array
25416956
种属内
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Anti Tag CoIP
20562859
种属内
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
TAP
16306228
种属内
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Anti Tag CoIP
25852190
种属内
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
TAP
23455922
种属内
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Anti Bait CoIP
22363791
种属内
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Y2H Array
21988832
种属内
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Pull Down
32707033
种属内
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Y2H Prey Pooling
25416956
种属内
PRKAA1 Q13131 PRKAB2 Homo sapiens O43741
Anti Tag CoIP
35271311
种属内
PRKAA1 Q13131 FSBP Homo sapiens O95073
Y2H Array
25416956
种属内
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
TAP
23455922
种属内
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Y2H Array
25416956
种属内
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
TAP
16306228
种属内
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Anti Tag CoIP
25852190
种属内
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Anti Tag CoIP
33961781
种属内
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Anti Bait CoIP
22363791
种属内
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Pull Down
32707033
种属内
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Anti Tag CoIP
35271311
种属内
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Y2H Array
31515488
种属内
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Anti Tag CoIP
20562859
种属内
PRKAA1 Q13131 PRKAG1 Homo sapiens P54619
Validated Y2H
25416956
种属内
PRKAA1 Q13131 ROPN1 Homo sapiens Q9HAT0
Y2H Array
31515488
种属内
PRKAA1 Q13131 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
25416956
种属内
PRKAA1 Q13131 SSX2IP Homo sapiens Q9Y2D8
Y2H Array
25416956
种属内
PRKAA1 Q13131 SSX2IP Homo sapiens Q9Y2D8
Y2H Prey Pooling
25416956
种属内
PRKAA1 Q13131 SSX2IP Homo sapiens Q9Y2D8
Validated Y2H
25416956
种属内
PRKAA1 Q13131 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
25416956
种属内
PRKAA1 Q13131 HMBOX1 Homo sapiens Q6NT76
Y2H Array
25416956
种属内
PRKAA1 Q13131 L3MBTL3 Homo sapiens Q96JM7
Validated Y2H
25416956
种属内
PRKAA1 Q13131 L3MBTL3 Homo sapiens Q96JM7
Y2H Array
25416956
种属内
PRKAA1 Q13131 VPS52 Homo sapiens Q8N1B4
Validated Y2H
25416956
种属内
PRKAA1 Q13131 HSP90AB1 Homo sapiens P08238
TAP
23455922
种属内
PRKAA1 Q13131 VPS37B Homo sapiens Q9H9H4
Y2H Array
25416956
种属内
PRKAA1 Q13131 VPS37B Homo sapiens Q9H9H4
Y2H Prey Pooling
25416956
种属内
PRKAA1 Q13131 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
种属内
PRKAA1 Q13131 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
种属内
PRKAA1 Q13131 BHLHE40 Homo sapiens O14503
Validated Y2H
25416956
种属内
PRKAA1 Q13131 BHLHE40 Homo sapiens O14503
Y2H Array
25416956
种属内
PRKAA1 Q13131 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
种属内
PRKAA1 Q13131 TLE5 Homo sapiens Q08117
Y2H Array
25416956
种属内
PRKAA1 Q13131 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
种属内
PRKAA1 Q13131 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
种属内
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
TAP
23455922
种属内
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
Anti Tag CoIP
18480843
种属内
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
TAP
16306228
种属内
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
Anti Bait CoIP
22363791
种属内
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
Pull Down
32707033
种属内
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
Anti Tag CoIP
35271311
种属内
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
Anti Tag CoIP
20562859
种属内
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
Anti Tag CoIP
33961781
种属内
PRKAA1 Q13131 PRKAB1 Homo sapiens Q9Y478
Anti Tag CoIP
25852190
种属内
PRKAA1 Q13131 TSC22D4 Homo sapiens Q9Y3Q8
Validated Y2H
25416956
种属内
PRKAA1 Q13131 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Array
25416956
种属内
PRKAA1 Q13131 ZBED1 Homo sapiens O96006
Y2H Array
25416956
种属内
PRKAA1 Q13131 ZBED1 Homo sapiens O96006
Y2H Prey Pooling
25416956
种属内
PRKAA1 Q13131 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
25416956
种属内
PRKAA1 Q13131 TRIP6 Homo sapiens Q15654
Validated Y2H
25416956
种属内
PRKAA1 Q13131 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
种属内
PRKAA1 Q13131 ABI2 Homo sapiens Q9NYB9
Y2H Prey Pooling
25416956
种属内
PRKAA1 Q13131 ABI2 Homo sapiens Q9NYB9
Validated Y2H
25416956
种属内
PRKAA1 Q13131 ABI2 Homo sapiens Q9NYB9
Y2H Array
25416956
种属内
PRKAA1 Q13131 ABI2 Homo sapiens Q9NYB9
Y2H Array
29892012
种属内
PRKAA1 Q13131 UBXN11 Homo sapiens Q5T124
Validated Y2H
25416956
种属内
PRKAA1 Q13131 RFX6 Homo sapiens Q8HWS3
Y2H Prey Pooling
25416956
种属内
PRKAA1 Q13131 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
25416956
种属内
PRKAA1 Q13131 INO80E Homo sapiens Q8NBZ0
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PRKAA1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76141 AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) P54619 (M1-P331)&Q9Y478 (M1-I270)&Q13131 (M1-Q559) ≥95%
HY-P76143 AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) P54619 (M1-P331)&O43741 (M1-I272)&Q13131 (M1-Q559) ≥95%

PRKAA1 抗体

目录号 产品名 应用 反应物种
HY-P80539 AMPK alpha 1 Antibody WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P80790 Phospho-AMPK alpha 1 (Ser496) Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Wolff-Parkinson-White Syndrome

Wolff-Parkinson-White Pattern

Wpw Syndrome

Anomalous Atrioventricular Excitation

Anomalous A-V Excitation

Ventricular Pre-Excitation With Arrhythmia

WPWS

Ventricular Familial Preexcitation Syndrome

Preexcitation Syndrome

Ventricular Preexcitation

Wpw - [Wolff-Parkinson- White] Syndrome

Pre-Excitation Syndrome
Myotonia
Cardia Cancer

Ca Cardia - Stomach

Malignant Neoplasm Of Cardia Of Stomach
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Diabetes Mellitus

Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148065 FMF-06-098-1 / 否
HY-RS11100 PRKAA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PRKAA1 MGD MGI:2145955
Macaca mulatta PRKAA1 VGNC VGNC:76399
Rattus norvegicus PRKAA1 RGD RGD:3387
Felis catus PRKAA1 VGNC VGNC:69045
Bos taurus PRKAA1 VGNC VGNC:50248
Canis familiaris PRKAA1 VGNC VGNC:51914
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