2. Gene
  3. Bcl2l2 - Bcl2-like 2 Gene

Bcl2l2 - Bcl2-like 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：Bcl2 样2

种属: Rattus norvegicus

同用名: Bclw; BCL-W; BCL-WS; BCL-WEL

基因 ID: 60434 | 基因类型: protein coding

关于 Bcl2l2

Primary_assembly 15: 28,356,807-28,361,624 forward strand.mRatBN7.2:CM026988.1

This gene has 1 transcript (splice variant), 61 orthologues, 13 paralogues and is associated with 12 phenotypes. Biased expression in Brain (RPKM 171.4), Kidney (RPKM 125.3) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 BH 域绑定活动。参与多个过程，包括细胞对雌二醇刺激的反应；细胞对有机氮化合物的反应；和从线粒体中释放细胞色素 c 的负调节。位于线粒体膜上。阿尔茨海默病的生物标志物；癫痫;翼状胬肉;和短暂性脑缺血。该基因的人类直系同源物与短暂性脑缺血有关。与人类 BCL2L2 同源（BCL2 like 2）。 [由基因组资源联盟提供，2022 年 4 月]

Enables BH domain binding activity. Involved in several processes, including cellular response to estradiol stimulus; cellular response to organonitrogen compound; and negative regulation of release of cytochrome c from mitochondria. Located in mitochondrial membrane. Biomarker of Alzheimer's disease; epilepsy; pterygium; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human BCL2L2 (BCL2 like 2). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l2 基因产物(1)

mRNA Protein Name
NM_021850.2 NP_068622.1 bcl-2-like protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables BH domain binding IPI
IPI: 通过物理相互作用推断
9356461 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15159385 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
9356461 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to amino acid stimulus IEP
IEP: 通过表达模式推断
11090983 RGD
involved in cellular response to amyloid-beta IEP
IEP: 通过表达模式推断
17287517 RGD
involved in cellular response to estradiol stimulus IEP
IEP: 通过表达模式推断
17287517 RGD
involved in cellular response to glycine IEP
IEP: 通过表达模式推断
11090983 RGD
involved in negative regulation of mitochondrial membrane permeability IDA
IDA: 通过直接分析推断
10724126 RGD
involved in negative regulation of release of cytochrome c from mitochondria IDA
IDA: 通过直接分析推断
10724126 RGD
involved in response to ischemia IEP
IEP: 通过表达模式推断
10724126 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
10724126 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Bcl2l2 蛋白结构

bcl-2

bcl-2: TIGR00865 (36 - 218)

  • 0
  • 100
  • 200
  • 219 a.a.
蛋白主名 其他名称

bcl-2-like protein 2

相关产品

Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-10969 Obatoclax Mesylate 99.85% Phase 3
HY-10969A Obatoclax ≥99.0% Phase 3
HY-109185 Pelcitoclax 99.70% Phase 2
HY-13559 Atiprimod / Phase 2
Pre-clinical Phase
生物活性分子 (43)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-50907 ABT-737 99.96% 否
HY-N0361 Dihydrocapsaicin 99.93% 否
HY-112416 AZD4320 Inhibitor 99.68% 否
HY-126741 Azadirachtin 99.06% 否
HY-N0265 Asperosaponin VI Inhibitor 98.91% 否
HY-103243 TCPOBOP Inhibitor 98.67% 否
HY-33350 Clofilium tosylate 99.84% 否
HY-120882 BM-1197 Inhibitor 99.48% 否
HY-12011 HA14-1 Inhibitor ≥98.0% 否
HY-129681 MCL-1/BCL-2-IN-1 Inhibitor 99.86% 否
HY-157176 BAX-IN-1 Inhibitor ≥98.0% 否
HY-161100 BDM19 Inducer 98.09% 否
HY-132307 Mcl-1 inhibitor 6 98.40% 否
HY-119931 2-Hydroxychalcone 98.80% 否
HY-129700 MCL-1/BCL-2-IN-2 Inhibitor 99.12% 否
HY-156278 FB49 Inhibitor 99.76% 否
HY-161410 WH244 Degrader / 否
HY-131247 Bcl-2-IN-2 Inhibitor / 否
HY-155188 NWP-0476 Inhibitor / 否
HY-101999 EM20-25 / 否
HY-123244 YC137 / 否
HY-125191 BRD1991 Inhibitor / 否
HY-13846 BM-1074 / 否
HY-143235 BRD4 Inhibitor-15 / 否
HY-144778 IDO1/TDO-IN-1 / 否
HY-146095 p53 Activator 2 / 否
HY-147929 Apoptotic agent-3 / 否
HY-149681 Beclin1-Bcl-2 interaction inhibitor 1 Inhibitor / 否
HY-157343 GD3 Ganglioside / 否
HY-157343A GD3 Ganglioside sodium ≥98.0% 否
HY-161577 BFC1103 / 否
HY-161659 Apoptosis inducer 19 / 否
HY-162148 HNPMI Inhibitor 99.57% 否
HY-162820 Bcl-2-IN-21 Inhibitor / 否
HY-162886 BSO-07 Activator / 否
HY-50907S ABT-737-d8 99.11% 否
HY-N0361S Dihydrocapsaicin-d3 / 否
HY-P5325 Bid BH3 (80-99) / 否
HY-RS01434 BCL2L2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01435 Bcl2l2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01436 Bcl2l2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-12011A (Rac)-HA14-1 Inhibitor / 否
HY-127057 Lambertianic acid / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990344 Anti-Bcl-2 Antibody Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bcl2l2 NCBI NCBI:599
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