1. Gene
  2. BCL2L2 - BCL2 like 2 Gene

BCL2L2 - BCL2 like 2 Gene

中文名称:BCL2 样 2

种属: Homo sapiens

同用名: BCLW; BCL-W; PPP1R51; BCL2-L-2

基因 ID: 599 | 基因类型: protein coding

关于 BCL2L2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,306,833-23,311,751 (from NCBI)

This gene has 10 transcripts (splice variants), 61 orthologues and 8 paralogues. Ubiquitous expression in brain (RPKM 35.0), fat (RPKM 31.5) and 25 other tissues.

功能概要

该基因编码 Bcl-2 蛋白家族的一个成员。该家族的蛋白质形成异二聚体或同二聚体,并充当抗和促凋亡调节剂。该基因在细胞中的表达已被证明有助于在细胞毒性条件下减少细胞凋亡。对小鼠相关基因的研究表明,它在依赖 NGF 和 BDNF 的神经元的存活中起作用。小鼠基因的突变和敲除研究表明在成人精子发生中起着重要作用。可变剪接导致多个转录本变体。该基因与邻近的下游 PABPN1 (poly (A) 结合蛋白,核 1) 基因之间也存在通读转录。[RefSeq 提供,2010 年 12 月]

This gene encodes a member of the Bcl-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell Apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

BCL2L2 基因产物(2)

mRNA Protein Name
NM_004050.5 NP_004041.2 bcl-2-like protein 2
NM_001199839.2 NP_001186768.2 bcl-2-like protein 2

BCL2L2 蛋白结构

BH4

BH4: Bcl-2 homology region 4 (7 - 31)

Bcl-2

Bcl-2: Apoptosis regulator proteins, Bcl-2 family (46 - 144)

  • 0
  • 100
  • 193 a.a.
蛋白主名 其他名称

bcl-2-like protein 2

apoptosis regulator BCL-W

protein phosphatase 1, regulatory subunit 51

BCL2L2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BCL2L2 Q92843 CISD2 Homo sapiens Q8N5K1 32296183
种属内
BCL2L2 Q92843 CISD2 Homo sapiens Q8N5K1 32296183
种属内
BCL2L2 Q92843 SGPL1 Homo sapiens O95470 32296183
种属内
BCL2L2 Q92843 SGPL1 Homo sapiens O95470 32296183
种属内
BCL2L2 Q92843 TMX1 Homo sapiens Q9H3N1 32296183
种属内
BCL2L2 Q92843 TMX1 Homo sapiens Q9H3N1 32296183
种属内
BCL2L2 Q92843 TMX1 Homo sapiens Q9H3N1 32296183
种属内
BCL2L2 Q92843 RTL10 Homo sapiens Q7L3V2 23055042
种属内
BCL2L2 Q92843 MGST2 Homo sapiens Q99735 32296183
种属内
BCL2L2 Q92843 MGST2 Homo sapiens Q99735 32296183
种属内
BCL2L2 Q92843 MGST2 Homo sapiens Q99735 32296183
种属内
BCL2L2 Q92843 TEX11 Homo sapiens Q8IYF3-3
Y2H
27107012
种属内
BCL2L2 Q92843 TEX11 Homo sapiens Q8IYF3-3 27107012
种属内
BCL2L2 Q92843 GPX8 Homo sapiens Q8TED1 32296183
种属内
BCL2L2 Q92843 GPX8 Homo sapiens Q8TED1 32296183
种属内
BCL2L2 Q92843 TMEM179B Homo sapiens Q7Z7N9 32296183
种属内
BCL2L2 Q92843 TMEM179B Homo sapiens Q7Z7N9 32296183
种属内
BCL2L2 Q92843 GPR151 Homo sapiens Q8TDV0 32296183
种属内
BCL2L2 Q92843 GPR151 Homo sapiens Q8TDV0 32296183
种属内
BCL2L2 Q92843 KCNJ6 Homo sapiens P48051 32296183
种属内
BCL2L2 Q92843 KCNJ6 Homo sapiens P48051 32296183
种属内
BCL2L2 Q92843 STOM Homo sapiens P27105 32296183
种属内
BCL2L2 Q92843 STOM Homo sapiens P27105 32296183
种属内
BCL2L2 Q92843 APOC1 Homo sapiens P02654 32296183
种属内
BCL2L2 Q92843 APOC1 Homo sapiens P02654 32296183
种属内
BCL2L2 Q92843 BNIP5 Homo sapiens P0C671 32296183
种属内
BCL2L2 Q92843 BNIP5 Homo sapiens P0C671 32296183
种属内
BCL2L2 Q92843 FGF14 Homo sapiens Q92915-2 32296183
种属内
BCL2L2 Q92843 FGF14 Homo sapiens Q92915-2 32296183
种属内
BCL2L2 Q92843 FGF14 Homo sapiens Q92915-2 32296183
种属内
BCL2L2 Q92843 SLC39A2 Homo sapiens Q9NP94 32296183
种属内
BCL2L2 Q92843 SLC39A2 Homo sapiens Q9NP94 32296183
种属内
BCL2L2 Q92843 SLC39A2 Homo sapiens Q9NP94 32296183
种属内
BCL2L2 Q92843 SLC39A6 Homo sapiens Q13433-2 32296183
种属内
BCL2L2 Q92843 SLC39A6 Homo sapiens Q13433-2 32296183
种属内
BCL2L2 Q92843 C10orf67 Homo sapiens Q8IYJ2-2 32296183
种属内
BCL2L2 Q92843 C10orf67 Homo sapiens Q8IYJ2-2 32296183
种属内
BCL2L2 Q92843 SLC35E3 Homo sapiens Q7Z769 32296183
种属内
BCL2L2 Q92843 SLC35E3 Homo sapiens Q7Z769 32296183
种属内
BCL2L2 Q92843 MUC1 Homo sapiens P15941-11 32296183
种属内
BCL2L2 Q92843 MUC1 Homo sapiens P15941-11 32296183
种属内
BCL2L2 Q92843 SLC35C2 Homo sapiens Q9NQQ7-3 32296183
种属内
BCL2L2 Q92843 SLC35C2 Homo sapiens Q9NQQ7-3 32296183
种属内
BCL2L2 Q92843 SLC35C2 Homo sapiens Q9NQQ7-3 32296183
种属内
BCL2L2 Q92843 CHODL Homo sapiens Q9H9P2 32296183
种属内
BCL2L2 Q92843 CHODL Homo sapiens Q9H9P2 32296183
种属内
BCL2L2 Q92843 CHODL Homo sapiens Q9H9P2 32296183
种属内
BCL2L2 Q92843 BHLHA9 Homo sapiens Q7RTU4 32296183
种属内
BCL2L2 Q92843 BHLHA9 Homo sapiens Q7RTU4 32296183
种属内
BCL2L2 Q92843 RHBDD2 Homo sapiens Q6NTF9-3 32296183
种属内
BCL2L2 Q92843 RHBDD2 Homo sapiens Q6NTF9-3 32296183
种属内
BCL2L2 Q92843 ERVFRD-1 Homo sapiens P60508 32296183
种属内
BCL2L2 Q92843 ERVFRD-1 Homo sapiens P60508 32296183
种属内
BCL2L2 Q92843 SUSD3 Homo sapiens Q96L08 32296183
种属内
BCL2L2 Q92843 SUSD3 Homo sapiens Q96L08 32296183
种属内
BCL2L2 Q92843 SUSD3 Homo sapiens Q96L08 32296183
种属内
BCL2L2 Q92843 APOC4 Homo sapiens P55056 32296183
种属内
BCL2L2 Q92843 APOC4 Homo sapiens P55056 32296183
种属内
BCL2L2 Q92843 ATP5PF Homo sapiens P18859 32296183
种属内
BCL2L2 Q92843 ATP5PF Homo sapiens P18859 32296183
种属内
BCL2L2 Q92843 LRP10 Homo sapiens Q7Z4F1 32296183
种属内
BCL2L2 Q92843 LRP10 Homo sapiens Q7Z4F1 32296183
种属内
BCL2L2 Q92843 GORAB Homo sapiens Q5T7V8 32296183
种属内
BCL2L2 Q92843 GORAB Homo sapiens Q5T7V8 32296183
种属内
BCL2L2 Q92843 BMF Homo sapiens Q96LC9 32296183
种属内
BCL2L2 Q92843 BMF Homo sapiens Q96LC9 25416956
种属内
BCL2L2 Q92843 BMF Homo sapiens Q96LC9 25416956
种属内
BCL2L2 Q92843 BMF Homo sapiens Q96LC9 32296183
种属内
BCL2L2 Q92843 BMF Homo sapiens Q96LC9 32296183
种属内
BCL2L2 Q92843 BMF Homo sapiens Q96LC9 25416956
种属内
BCL2L2 Q92843 SAR1A Homo sapiens Q9NR31 32296183
种属内
BCL2L2 Q92843 SAR1A Homo sapiens Q9NR31 32296183
种属内
BCL2L2 Q92843 SAR1A Homo sapiens Q9NR31 32296183
种属内
BCL2L2 Q92843 G0S2 Homo sapiens P27469 32296183
种属内
BCL2L2 Q92843 G0S2 Homo sapiens P27469 32296183
种属内
BCL2L2 Q92843 BAX Homo sapiens Q07812 17289999
种属内
BCL2L2 Q92843 BAX Homo sapiens Q07812 21199865
种属内
BCL2L2 Q92843 BAX Homo sapiens Q07812 33961781
种属内
BCL2L2 Q92843 BID Homo sapiens P55957 33961781
种属内
BCL2L2 Q92843 BID Homo sapiens P55957
FPS
16697956
种属内
BCL2L2 Q92843 BAK1 Homo sapiens Q16611 32296183
种属内
BCL2L2 Q92843 BAK1 Homo sapiens Q16611 25416956
种属内
BCL2L2 Q92843 BAK1 Homo sapiens Q16611 32296183
种属内
BCL2L2 Q92843 BAK1 Homo sapiens Q16611 25416956
种属内
BCL2L2 Q92843 BBC3 Homo sapiens Q9BXH1 28514442
种属内
BCL2L2 Q92843 BCL2L11 Homo sapiens O43521 33961781
种属内
BCL2L2 Q92843 BCL2L11 Homo sapiens O43521 32296183
种属内
BCL2L2 Q92843 BCL2L11 Homo sapiens O43521 32296183
种属内
BCL2L2 Q92843 TCF4 Homo sapiens P15884 25416956
种属内
BCL2L2 Q92843 TCF4 Homo sapiens P15884 25416956
种属内
BCL2L2 Q92843 BAD Homo sapiens Q92934 32296183
种属内
BCL2L2 Q92843 BAD Homo sapiens Q92934 32296183
种属内
BCL2L2 Q92843 BAD Homo sapiens Q92934
ITC
22000515
种属内
BCL2L2 Q92843 BAD Homo sapiens Q92934 32296183
种属内
BCL2L2 Q92843 BIK Homo sapiens Q13323
Y2H
27107012
种属内
BCL2L2 Q92843 BIK Homo sapiens Q13323 27107012
种属内
BCL2L2 Q92843 BIK Homo sapiens Q13323
SLC
27107012
种属内
BCL2L2 Q92843 BIK Homo sapiens Q13323 27107012
种属内
BCL2L2 Q92843 BIK Homo sapiens Q13323 32296183
种属内
BCL2L2 Q92843 BIK Homo sapiens Q13323 32296183
种属内
BCL2L2 Q92843 PANX1 Homo sapiens Q96RD7 32296183
种属内
BCL2L2 Q92843 PANX1 Homo sapiens Q96RD7 32296183
种属内
BCL2L2 Q92843 PANX1 Homo sapiens Q96RD7 32296183
种属内
BCL2L2 Q92843 ANKS6 Homo sapiens Q68DC2 32296183
种属内
BCL2L2 Q92843 ANKS6 Homo sapiens Q68DC2 32296183
种属内
BCL2L2 Q92843 CIDEB Homo sapiens Q9UHD4 32296183
种属内
BCL2L2 Q92843 CIDEB Homo sapiens Q9UHD4 32296183
种属内
BCL2L2 Q92843 CIDEB Homo sapiens Q9UHD4 32296183
种属间
BCL2L2 Q92843 Bmf Mus musculus Q91ZE9
FPS
16697956
种属内
BCL2L2 Q92843 TMEM139 Homo sapiens Q8IV31 32296183
种属内
BCL2L2 Q92843 TMEM139 Homo sapiens Q8IV31 32296183
种属内
BCL2L2 Q92843 CLDN7 Homo sapiens O95471 32296183
种属内
BCL2L2 Q92843 CLDN7 Homo sapiens O95471 32296183
种属内
BCL2L2 Q92843 FATE1 Homo sapiens Q969F0 32296183
种属内
BCL2L2 Q92843 FATE1 Homo sapiens Q969F0 32296183
种属内
BCL2L2 Q92843 FATE1 Homo sapiens Q969F0 25416956
种属内
BCL2L2 Q92843 FATE1 Homo sapiens Q969F0 32296183
种属内
BCL2L2 Q92843 KASH5 Homo sapiens Q8N6L0 32296183
种属内
BCL2L2 Q92843 KASH5 Homo sapiens Q8N6L0 27107012
种属内
BCL2L2 Q92843 KASH5 Homo sapiens Q8N6L0 32296183
种属内
BCL2L2 Q92843 CD79A Homo sapiens P11912 32296183
种属内
BCL2L2 Q92843 CD79A Homo sapiens P11912 32296183
种属内
BCL2L2 Q92843 ERGIC3 Homo sapiens Q9Y282 32296183
种属内
BCL2L2 Q92843 ERGIC3 Homo sapiens Q9Y282 32296183
种属内
BCL2L2 Q92843 ERGIC3 Homo sapiens Q9Y282 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 BCL2L2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7653 Bcl-2-like protein 2 Protein, Human (His) AAI13523.1 (A2-T172) ≥95%

关联疾病

疾病名称 别名
Blood Platelet Disease

Platelet Disorder

Blood Platelet Disorders

Thrombocytopathy

Platelet Dysfunction

Platelet Disorders

Qualitative Platelet Deficiency

B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus BCL2L2 RGD RGD:620717
Mus musculus BCL2L2 MGD MGI:108052
Bos taurus BCL2L2 VGNC VGNC:55105
Others BCL2L2 NCBI