2. Gene
  3. HDAC11 - histone deacetylase 11 Gene

HDAC11 - histone deacetylase 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：组蛋白脱乙酰酶 11

种属: Homo sapiens

同用名: HD11

基因 ID: 79885 | 基因类型: protein coding

关于 HDAC11

Cytogenetic location: 3p25.1 Genomic coordinates (GRCh38): 3:13,480,306-13,506,416 (from NCBI)

This gene has 21 transcripts (splice variants), 198 orthologues and 10 paralogues. Broad expression in brain (RPKM 17.4), testis (RPKM 14.8) and 22 other tissues.

功能概要

该基因编码 IV 类组蛋白脱乙酰酶。编码的蛋白质定位于细胞核，可能参与调节白细胞介素 10 的表达。选择性剪接导致多种转录物变异。[RefSeq 提供，2009 年 4 月]

This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]

HDAC11 基因产物(3)

mRNA Protein Name
NM_001136041.3 NP_001129513.1 histone deacetylase 11 isoform 2
NM_001330636.2 NP_001317565.1 histone deacetylase 11 isoform 3
NM_024827.4 NP_079103.2 histone deacetylase 11 isoform 1

HDAC11 蛋白结构

Hist_deacetyl

Hist_deacetyl: Histone deacetylase domain (30 - 318)

  • 0
  • 100
  • 200
  • 300
  • 347 a.a.
蛋白主名 其他名称

histone deacetylase 11

HDAC11 抗体

目录号 产品名 应用 反应物种
HY-P83139 HDAC11 Antibody (YA2884) WB, IP Human

关联疾病

疾病名称 别名
Mature T-Cell And Nk-Cell Lymphoma

Mature T-Cell And Natural Killer Cell Lymphoma

Nk-T Cell Lymphoma
Peripheral T-Cell Lymphoma

Lymphoma T-Cell Peripheral
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10221 Vorinostat Inhibitor 99.95% 是
HY-109015 Tucidinostat Inhibitor 98.60% 否
HY-12164 Mocetinostat Inhibitor 99.68% 是
HY-13322 Pracinostat Inhibitor 99.82% 是
HY-14842 Givinostat Inhibitor 98.16% 是
Clinical Phase
生物活性分子 (7)
目录号 产品名 作用方式
纯度 Phase
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Phase 2
HY-16012A Domatinostat Inhibitor 99.43% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
Pre-clinical Phase
生物活性分子 (38)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13428 Tubacin Inhibitor 99.54% 否
HY-18998 LMK-235 Inhibitor 99.61% 否
HY-112285 FT895 Inhibitor 99.84% 否
HY-128918 SIS17 Inhibitor 99.65% 否
HY-145757 Elevenostat Inhibitor 95.85% 否
HY-16699 Nexturastat A Inhibitor 98.28% 否
HY-115475 SW-100 Inhibitor 99.93% 否
HY-126330 SS-208 Inhibitor 99.00% 否
HY-110280 MC1742 Inhibitor 99.20% 否
HY-114483 AES-135 Inhibitor 98.21% 否
HY-138831 AES-350 Inhibitor 99.30% 否
HY-143412 MIR002 Inhibitor ≥99.0% 否
HY-143411 GEM144 Inhibitor / 否
HY-150109 Purinostat mesylate Inhibitor 99.45% 否
HY-157740 XSJ-10 Inhibitor / 否
HY-161778 ZG-126 Inhibitor / 否
HY-152225 MC2625 Inhibitor / 否
HY-150772 Tubulin/HDAC-IN-1 Inhibitor / 否
HY-169400 HDACs/EZH2-IN-1 Inhibitor / 否
HY-150595 HDAC6-IN-10 Inhibitor / 否
HY-157889 ZINC000028464438 Inhibitor / 否
HY-146684 HDAC-IN-36 Inhibitor / 否
HY-163803 CM-444 Inhibitor / 否
HY-15144B (S)-Trichostatin A Inhibitor / 否
HY-151263 G4/HDAC-IN-1 Inhibitor / 否
HY-152226 MC2590 Inhibitor / 否
HY-162630 HDAC6-IN-44 Inhibitor / 否
HY-159171 sEH/HDAC6-IN-2 Inhibitor / 否
HY-152173 HDAC-IN-51 Inhibitor / 否
HY-161350 ALK/HDAC-IN-1 Inhibitor / 否
HY-147966 HDAC-IN-43 Inhibitor / 否
HY-143877 NN-390 Inhibitor / 否
HY-157481 HDAC1-IN-6 Inhibitor / 否
HY-163207 sEH/HDAC6-IN-1 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-170379 HDAC-IN-84 Inhibitor / 否
HY-162658 Leuxinostat Inhibitor / 否
HY-135714 Bavarostat Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HDAC11 MGD MGI:2385252
Canis familiaris HDAC11 VGNC VGNC:50627
Macaca mulatta HDAC11 VGNC VGNC:73196
Felis catus HDAC11 VGNC VGNC:62766
Bos taurus HDAC11 VGNC VGNC:49150
Rattus norvegicus HDAC11 RGD RGD:1311706
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