CD37 - CD37 molecule Gene

中文名称：CD37 分子

种属: Homo sapiens

同用名: GP52-40; TSPAN26

基因 ID: 951 | 基因类型: protein coding

关于 CD37

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,335,406-49,340,606 (from NCBI)

This gene has 15 transcripts (splice variants), 132 orthologues and 32 paralogues. Biased expression in lymph node (RPKM 111.7), spleen (RPKM 99.3) and 8 other tissues.

功能概要

由该基因编码的蛋白质是跨膜 4 超家族的成员，也称为四跨膜蛋白家族。这些成员中的大多数是细胞表面蛋白，其特征在于存在四个疏水结构域。这些蛋白质介导在细胞发育、活化、生长和运动的调节中起作用的信号转导事件。这种编码的蛋白质是一种细胞表面糖蛋白，已知与整合素和其他跨膜 4 超家族蛋白复合。它可能在 T 细胞-B 细胞相互作用中发挥作用。交替剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and Other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CD37 基因产物(2)

mRNA	Protein	Name
NM_001040031.2	NP_001035120.1	leukocyte antigen CD37 isoform B
NM_001774.3	NP_001765.1	leukocyte antigen CD37 isoform A

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21930792	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in immunological synapse	IDA IDA: 通过直接分析推断	21930792	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD37 蛋白结构

Tetraspannin

0
100
200
281 a.a.

蛋白主名

其他名称

leukocyte antigen CD37

cell differentiation antigen 37

CD37 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CD37	P11049	GJB1	Homo sapiens	P08034	Y2H Prey Pooling	32296183
种属内	CD37	P11049	GJB1	Homo sapiens	P08034	Y2H Array	32296183
种属内	CD37	P11049	LRRC3B	Homo sapiens	Q96PB8	Validated Y2H	32296183
种属内	CD37	P11049	LRRC3B	Homo sapiens	Q96PB8	Y2H Prey Pooling	32296183
种属内	CD37	P11049	LRRC3B	Homo sapiens	Q96PB8	Y2H Array	32296183
种属内	CD37	P11049	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
种属内	CD37	P11049	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
种属内	CD37	P11049	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
种属内	CD37	P11049	EMP1	Homo sapiens	P54849	Y2H Prey Pooling	32296183
种属内	CD37	P11049	EMP1	Homo sapiens	P54849	Validated Y2H	32296183
种属内	CD37	P11049	EMP1	Homo sapiens	P54849	Y2H Array	32296183
种属内	CD37	P11049	CD53	Homo sapiens	P19397	Validated Y2H	32296183
种属内	CD37	P11049	CD53	Homo sapiens	P19397	Y2H Array	32296183
种属内	CD37	P11049	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
种属内	CD37	P11049	PTPN6	Homo sapiens	P29350	Anti Bait CoIP	22624718
种属内	CD37	P11049	SYK	Homo sapiens	P43405	Anti Bait CoIP	22624718
种属内	CD37	P11049	LYN	Homo sapiens	P07948	Anti Bait CoIP	22624718

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD37 蛋白

目录号	产品名	蛋白编号	纯度
HY-P77886	CD37 Protein, Human (HEK293, Fc)	P11049 (A113-N240)	≥95%

CD37 抗体

目录号	产品名	应用	反应物种
HY-P81648	CD37 Antibody (YA1393)	FC, ELISA	Human

关联疾病

疾病名称

别名

High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit

Hgbl-Dh/Th	High Grade B-Cell Lymphoma With Myc And Bcl2 Or Bcl6 Rearrangements
High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement

Osteogenesis Imperfecta, Type Iii

Osteogenesis Imperfecta Type Iii	OI3
Oi, Type Iii	Osteogenesis Imperfecta Type 3
Oi Type Iii	Oi Type 3
Progressive Deforming Osteogenesis Imperfecta	Severe Osteogenesis Imperfecta
Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae	Progressively Deforming Osteogenesis Imperfecta With Normal Sclera
Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae	Progressively Deforming Oi
Osteogenesis Imperfecta 3	Oi-Iii
Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae

Mantle Cell Lymphoma

Lymphoma, Mantle Cell	Lcm
Mcl	Mantle Zone Lymphoma
Lymphoma Mantle-Cell	Lymphoma, Mantle-Cell
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse	Malignant Lymphoma - Lymphocytic, Intermediate Differentiation
Diffuse Small Cleaved-Cell Lymphoma	Diffuse Small Cleaved Cell Malignant Lymphoma
Small Cleaved Cell Non-Hodgkin Lymphoma	Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma
Malignant Lymphomatous Polyposis	Malignant Small Cell, Noncleaved, Diffuse Lymphoma
Malignant Undifferentiated Cell, Non-Burkitt Lymphoma	Cleaved Cell Lymphoma
Small Cell Mantle Cell Lymphoma	Small Cleaved Cell Malignant Lymphoma

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P99707	Lilotomab	Inducer	98.99%	Phase 2
HY-132260	Naratuximab emtansine	Inducer	/	Phase 2
HY-P99674	Ivicentamab	Inhibitor	/	Phase 2
HY-P990317	AGS-67E	Inhibitor	/	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02238	CD37 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P99374	Naratuximab		≥99.0%	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CD37	VGNC	VGNC:70761
Canis familiaris	CD37	VGNC	VGNC:38952
Felis catus	CD37	VGNC	VGNC:60615
Mus musculus	CD37	MGD	MGI:88330
Rattus norvegicus	CD37	RGD	RGD:62035
Bos taurus	CD37	VGNC	VGNC:27026
Macaca fascicularis	CD37	NCBI	NCBI:102117577
Others	CD37	NCBI

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