Pendimethalin (Synonyms: 二甲戊灵)

目录号: HY-B0862 纯度: 99.75%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Pendimethalin 是具有口服活性的除草剂，可控制一年生禾草和某些阔叶杂草。Pendimethalin 通过激活内质网应激介导的线粒体功能障碍，诱导人脐静脉内皮细胞的凋亡 (Apoptotic) 细胞死亡。

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Pendimethalin Chemical Structure

CAS No. : 40487-42-1

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规格	价格	是否有货
Free Sample (0.1 - 0.2 mg)		Apply now
10 mM * 1 mL in DMSO	￥385	In-stock
100 mg	￥350	In-stock
500 mg	￥550	In-stock
1 g	￥880	In-stock
5 g	￥2200	In-stock
10 g	￥3300	In-stock
50 g		询价

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Customer Review

Other Forms of Pendimethalin:

Pendimethalin-d₅ 询价
Pendimethalin (Standard) 询价

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生物活性
纯度 & 产品资料
参考文献

生物活性

Pendimethalin is an orally active herbicide that controls annual grasses and certain broadleaf weeds. Pendimethalin induces Apoptotic cell death through activating ER stress-mediated mitochondrial dysfunction in human umbilical vein endothelial cells^[1]^[2]^[3]^[4].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
HFF	IC₅₀	0.26 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	0.34 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235V mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235V mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	0.71 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235T mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235T mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	0.75 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin S6I mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin S6I mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235L mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235L mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1.1 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243C mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243C mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	12.2 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin T239I mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin T239I mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	13.2 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin L136F mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin L136F mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	2.5 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin H28Q mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin H28Q mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	3.2 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin V4L mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin V4L mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	3.2 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin F24H mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin F24H mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	9.7 μM Compound: 11	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243S mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243S mutation infected in HFF cells by plaque assay	[PMID: 20145086]

体外研究
(In Vitro)

Pendimethalin (50 和 100 μM，24 小时) 显著降低人类血管内皮细胞 (HUVECs) 的细胞活力、导致细胞周期停滞、凋亡、内质网应激、自噬以及线粒体功能障碍^[2]。
Pendimethalin (25-100 μM，6 小时) 抑制 HUVECs 的迁移和管道形成^[2]。
Pendimethalin (50-200 μM，3 小时) 在人类淋巴细胞中表现出 DNA 损伤^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	HUVECs
Concentration:	50 and 100 μM
Incubation Time:	24 h
Result:	Decreased the cell viability of 57% and 73% at 50 and 100 μM in HUVECs.

Cell Cycle Analysis^[2]

Cell Line:	HUVECs
Concentration:	50 and 100 μM
Incubation Time:	24 h
Result:	Increased the proportion of cells in the G1 phase in HUVECs.

Apoptosis Analysis^[2]

Cell Line:	HUVECs
Concentration:	50 and 100 μM
Incubation Time:	24 h
Result:	Significantly increased proportions of necrotic cells in HUVECs.

体内研究
(In Vivo)

Pendimethalin (12.5-50 mg/kg，口服强饲，每天一次，持续 14 天) 在大鼠骨髓细胞中表现出 DNA 损伤，并降低了 GSH 和 CAT 的水平，同时增加了 LPO 的水平^[3]。
Pendimethalin (62.5-250 mg/kg，口服一次，持续 14 天) 在大鼠的肝脏和肾脏中引起氧化应激，这表现在超氧化物歧化酶 (SOD)、过氧化氢酶 (CAT)、谷胱甘肽 (GSH) 和谷胱甘肽 S-转移酶 (GST) 水平明显下降，同时 TBARS 和羰基含量升高，导致肝脏和肾脏损伤，表现出库普弗细胞活化和白细胞浸润，以及细胞质大内泡化和血窦扩张^[4]。
Pendimethalin (62.5-250 mg/kg，口服一次，持续 14 天) 明显上调了抗炎和凋亡标志物，如肿瘤坏死因子 α (TNF-α)、干扰素 γ (IFN-γ)、Bax 和半胱氨酸蛋白酶-3 的表达，并下调了 Bcl-2，同时 TNF-α 基因的 mRNA 表达显著上调^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (140±10 g), 8–9 weeks^[2]
Dosage:	12.5-50 mg/kg
Administration:	oral gavage, daily for 14 days
Result:	Induced 1.6, 4.9, and 10.5-fold (p<0.05) increase in comet OTM value at 12.5, 25, and 50 mg/kg b w/day.

分子量

281.31

Formula

C₁₃H₁₉N₃O₄

CAS 号

40487-42-1

性状

固体

颜色

Orange to red

中文名称

二甲戊灵；二甲戊乐灵

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : 50 mg/mL (177.74 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.5548 mL	17.7740 mL	35.5480 mL
5 mM	0.7110 mL	3.5548 mL	7.1096 mL
10 mM	0.3555 mL	1.7774 mL	3.5548 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.89 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (8.89 mM); 悬浊液; 超声助溶

此方案可获得 2.5 mg/mL的均匀悬浊液，悬浊液可用于口服和腹腔注射。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.75%

选择批次：

Data Sheet (652 KB) SDS (537 KB)

COA (290 KB) HNMR (244 KB) LCMS (269 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Martin Kočárek, et al. Effect of adjuvant on pendimethalin and dimethenamid-P behaviour in soil. J Hazard Mater. 2018 Jul 15;354:266-274. [Content Brief]

[2]. Lee HS, et al. Pendimethalin induces apoptotic cell death through activating ER stress-mediated mitochondrial dysfunction in human umbilical vein endothelial cells. Food Chem Toxicol. 2022 Oct;168:113370. [Content Brief]

[3]. Ansari SM, et al. Pendimethalin induces oxidative stress, DNA damage, and mitochondrial dysfunction to trigger apoptosis in human lymphocytes and rat bone-marrow cells. Histochem Cell Biol. 2018 Feb;149(2):127-141. [Content Brief]

[4]. Ahmad MI, et al. Pendimethalin-induced oxidative stress, DNA damage and activation of anti-inflammatory and apoptotic markers in male rats. Sci Rep. 2018 Nov 20;8(1):17139. [Content Brief]

Pendimethalin 相关分类

Others

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5548 mL	17.7740 mL	35.5480 mL	88.8699 mL
	5 mM	0.7110 mL	3.5548 mL	7.1096 mL	17.7740 mL
	10 mM	0.3555 mL	1.7774 mL	3.5548 mL	8.8870 mL
	15 mM	0.2370 mL	1.1849 mL	2.3699 mL	5.9247 mL
	20 mM	0.1777 mL	0.8887 mL	1.7774 mL	4.4435 mL
	25 mM	0.1422 mL	0.7110 mL	1.4219 mL	3.5548 mL
	30 mM	0.1185 mL	0.5925 mL	1.1849 mL	2.9623 mL
	40 mM	0.0889 mL	0.4443 mL	0.8887 mL	2.2217 mL
	50 mM	0.0711 mL	0.3555 mL	0.7110 mL	1.7774 mL
	60 mM	0.0592 mL	0.2962 mL	0.5925 mL	1.4812 mL
	80 mM	0.0444 mL	0.2222 mL	0.4443 mL	1.1109 mL
	100 mM	0.0355 mL	0.1777 mL	0.3555 mL	0.8887 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pendimethalin40487-42-1二甲戊灵二甲戊乐灵ApoptosisSODCaspaseBcl-2 FamilySuperoxide Dismutaseorally activegrassesbroadleaf weedsApoptoticmitochondrial dysfunctionhuman umbilical vein endothelial cellsInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Pendimethalin (Synonyms: 二甲戊灵)

Customer Review

Other Forms of Pendimethalin: