2. Anti-infection Cell Cycle/DNA Damage Apoptosis Autophagy NF-κB Immunology/Inflammation Metabolic Enzyme/Protease
  3. Antibiotic Bacterial ATF6 DAPK Autophagy NF-κB NO Synthase Apoptosis Reactive Oxygen Species (ROS) Keap1-Nrf2 Heme Oxygenase (HO)
  4. Quinocetone

Quinocetone  (Synonyms: 喹烯酮)

目录号: HY-123581 纯度: 98.00%
COA 产品使用指南 技术支持

Quinocetone 是一种口服有效的动物饲料添加剂，用于提高牲畜和家禽的产肉量。Quinocetone 对多种致病微生物具有抗菌活性。Quinocetone 具有组织特异性 (肝脏、淋巴细胞) 毒性。Quinocetone 通过 ATF6/DAPK1 通路诱导细胞自噬 (autophagy)。Quinocetone 可激活 NF-κB 和 iNOS 通路，导致细胞凋亡 (apoptosis)、肝细胞空泡变性和纤维化。Quinocetone 可抑制 Nrf2/HO-1，诱导活性氧 (ROS) 的生成，从而导致氧化应激和 DNA 损伤。

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Quinocetone

Quinocetone Chemical Structure

CAS No. : 81810-66-4

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥462
In-stock
50 mg ￥420
In-stock
100 mg ￥600
In-stock
250 mg ￥1000
In-stock
500 mg ￥1500
In-stock
1 g ￥2250
In-stock
5 g   询价  
10 g   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Quinocetone:

Quinocetone 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

查看所有亚型
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 NO Synthase 亚型特异性产品:

查看所有亚型
nNOS iNOS eNOS

查看 Heme Oxygenase (HO) 亚型特异性产品:

查看所有亚型
HO-1 HO-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Quinocetone is an orally active animal feed additive used to increase the meat production of livestock and poultry. Quinocetone exhibits antibacterial activity against a variety of pathogenic microorganisms. Quinocetone exhibits tissue-specific (liver, lymphocyte) toxicity. Quinocetone induces autophagy in cells through the ATF6/DAPK1 pathway. Quinocetone activates the NF-κB and iNOS pathways, leading to cell apoptosis, hepatocyte vacuolar degeneration and fibrosis. Quinocetone can inhibit Nrf2/HO-1 and induce the generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage[1][2][3][4].

IC50 & Target[2][3][4]

NF-κB

 

iNOS

 

DAPK1

 

HO-1

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM IC50
5.92 μM
Compound: 3a
Growth inhibition of human CEM cells after 3 days
Growth inhibition of human CEM cells after 3 days
[PMID: 19427790]
HL-60 CC50
4.1 μM
Compound: 3a
Cytotoxicity against human HL60 cells after 48 hrs
Cytotoxicity against human HL60 cells after 48 hrs
[PMID: 19427790]
HSC-2 CC50
8.4 μM
Compound: 3a
Cytotoxicity against human HSC2 cells after 48 hrs
Cytotoxicity against human HSC2 cells after 48 hrs
[PMID: 19427790]
HSC-3 CC50
9.7 μM
Compound: 3a
Cytotoxicity against human HSC3 cells after 48 hrs
Cytotoxicity against human HSC3 cells after 48 hrs
[PMID: 19427790]
HSC-4 CC50
9.6 μM
Compound: 3a
Cytotoxicity against human HSC4 cells after 48 hrs
Cytotoxicity against human HSC4 cells after 48 hrs
[PMID: 19427790]
MOLT-4 IC50
6.76 μM
Compound: 3a
Growth inhibition of human Molt4/C8 cells after 3 days
Growth inhibition of human Molt4/C8 cells after 3 days
[PMID: 19427790]
体外研究
(In Vitro)

Quinocetone 对犬小孢子菌、鸡毒支原体和猪肺炎支原体有抑制作用，MIC 分别为 8、8 和 16 μg/mL，但对法氏囊病病毒、猪繁殖与呼吸综合征病毒、猪细小病毒和猪瘟病毒等多种动物病毒无显著抑制作用[1]。
Quinocetone (0-10 μg/mL，0-24 小时) 通过 ATF6/DAPK1 调控的 mAtg9a 运输，引发 HepG2 细胞内质网应激诱导的自噬[2]。
Quinocetone (0-20 μg/mL，6-24 小时) 可抑制人体外周淋巴细胞的生长，引发活性氧 (ROS) 升高，并诱导 DNA 损伤[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Quinocetone 相关抗体:

Western Blot Analysis[2].

Cell Line: HepG2 cells
Concentration: 0, 1.25, 2.5, 5, 7.5, 10 μg/mL
Incubation Time: 0, 1.5, 3, 6, 9, 12, 24 h
Result: Significantly increased the LC3-II/LC3-I ratio.
Dose-dependently upregulated BiP and CHOP expression and increased ATF6 cleavage.
Significantly upregulated DAPK1 expression and MRLC phosphorylation.

RT-PCR[2].

Cell Line: HepG2 cells
Concentration: 0, 1.25, 2.5, 5, 7.5, 10 μg/mL
Incubation Time: 0, 1.5, 3, 6, 9, 12, 24 h
Result: Increased BiP, HerpUD and sec24D transcription.
Increased DAPK1 mRNA.
体内研究
(In Vivo)

Quinocetone (50-2400 mg/kg，灌胃，每日一次，持续 13 周) 诱导了 Nrf2/HO-1 通路抑制，在高剂量下加剧了 Sprague-Dawley 大鼠的肝细胞损伤[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hepatocyte damage assay established in adult male SD rats[4]
Dosage: 50, 800 and 2400 mg/kg
Administration: Intragastrical administration (p.o.), once daily for 13 weeks
Result: Kept all rats survived and no obviously significant changes were observed in mortality, illness and clinical signs.
Induced liver damage and liver was likely to be the target organ at high dose.
Aggravated ROS accumulation in liver and aggravated DNA damage at high dose.
Aggravated inflammation and apoptosis of hepatocyte at high dose.
Inhibited aggravated inflammation and apoptosis of hepatocyte at high dose.
分子量

306.32

Formula

C18H14N2O3
CAS 号
性状

固体

颜色

White to yellow

中文名称

喹烯酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (326.46 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.2646 mL 16.3228 mL 32.6456 mL
5 mM 0.6529 mL 3.2646 mL 6.5291 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Quinocetone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2646 mL 16.3228 mL 32.6456 mL 81.6140 mL
5 mM 0.6529 mL 3.2646 mL 6.5291 mL 16.3228 mL
10 mM 0.3265 mL 1.6323 mL 3.2646 mL 8.1614 mL
15 mM 0.2176 mL 1.0882 mL 2.1764 mL 5.4409 mL
20 mM 0.1632 mL 0.8161 mL 1.6323 mL 4.0807 mL
25 mM 0.1306 mL 0.6529 mL 1.3058 mL 3.2646 mL
30 mM 0.1088 mL 0.5441 mL 1.0882 mL 2.7205 mL
40 mM 0.0816 mL 0.4081 mL 0.8161 mL 2.0403 mL
50 mM 0.0653 mL 0.3265 mL 0.6529 mL 1.6323 mL
60 mM 0.0544 mL 0.2720 mL 0.5441 mL 1.3602 mL
80 mM 0.0408 mL 0.2040 mL 0.4081 mL 1.0202 mL
100 mM 0.0326 mL 0.1632 mL 0.3265 mL 0.8161 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinocetone81810-66-4喹烯酮AntibioticBacterialATF6DAPKAutophagyNF-κBNO SynthaseApoptosisReactive Oxygen Species (ROS)Keap1-Nrf2Heme Oxygenase (HO)Activating transcription factor 6Death associated protein kinaseNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSHeme OxygenaseNrf2/HO-1 pathwayOxidative stressCytotoxicityDNA damageGenotoxicityHuman lymphocytesInhibitorinhibitorinhibit

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