2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage Stem Cell/Wnt Anti-infection PI3K/Akt/mTOR Apoptosis
  3. Glucose-6-Phosphate Isomerase (GPI) Casein Kinase Virus Protease Flavivirus PI3K Akt mTOR Apoptosis
  4. Rhodiolin

Rhodiolin 是一种类黄酮，是一种口服有效的葡萄糖6-磷酸异构酶 (GPI) 抑制剂。Rhodiolin 通过靶向糖酵解中葡萄糖-6-磷酸异构酶 GPI，抑制 PI3K/AKT/mTOR 磷酸化，从而抑制乳头状甲状腺癌 (PTC)，并诱导细胞凋亡 (apoptosis)。Rhodiolin 可靶向 NS2B-NS3，从而抑制登革热病毒的复制。Rhodiolin 也是开发抑制 CK1ε 激酶的抗癌策略的潜在候选者。Rhodiolin 可用于抗肿瘤和抗病毒研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Rhodiolin

Rhodiolin Chemical Structure

CAS No. : 86831-53-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货
1 mg ￥2860
询问价格 & 货期
5 mg 询价 询问价格 & 货期

* Please select Quantity before adding items.

Customer Review

Rhodiolin 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Casein Kinase 亚型特异性产品:

查看所有亚型
CK1 CK2

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

查看 mTOR 亚型特异性产品:

查看所有亚型
mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rhodiolin, a flavonoid, is an orally active glucose 6-phosphate isomerase (GPI) inhibitor. Rhodiolin inhibits papillary thyroid cancer (PTC) by targeting glycolysis enzyme glucose 6-phosphate isomerase GPI and suppressing PI3K/AKT/mTOR phosphorylation and induce apoptosis. Rhodiolin as a NS2B-NS3 protease inhibitor can disrupt dengue viral replication. Rhodiolin is also a potential candidate for developing anticancer strategies inhibiting CK1ε kinase. Rhodiolin can be used for the study of anti-tumor and anti-viral [1][2][3].

IC50 & Target[1]

CK1ε

 

PI3K

 

Akt

 

mTOR

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MDCK CC50
> 300 μM
Compound: 9
Cytotoxicity against MDCK cells after 48 hrs by MTT assay
Cytotoxicity against MDCK cells after 48 hrs by MTT assay
[PMID: 19729316]
体外研究
(In Vitro)

Rhodiolin (0-40 μM, 24 h) 在 PTC 细胞中诱导 G1/S 期细胞周期停滞[1]。
Rhodiolin (0-40 μM, 12-24 h) 通过下调 GPI 的表达阻断糖酵解，抑制 PI3K/Akt/mTOR 信号通路，进而抑制 PTC 细胞的增殖并诱导其凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rhodiolin 相关抗体:

Cell Cycle Analysis[1]

Cell Line: PTC cells
Concentration: 10, 20 and 40 μM
Incubation Time: 24 h
Result: Showed a dose-dependent reduction in S-phase cells.

Apoptosis Analysis[1]

Cell Line: PTC cells
Concentration: 10, 20 and 40 μM
Incubation Time: 12 h
Result: Observed A dose-dependent increase in the percentage of cells undergoing early apoptosis and late apoptosis.
Caused dose-dependent reduction in MMP.
Reduced the number of mitochondria in tumor cells significantly while increasing the intracellular oxidation level.

Western Blot Analysis[1]

Cell Line: PTC cells
Concentration: 10, 20 and 40 μM
Incubation Time: 24 h
Result: Decreased the expression of cyclin E, CDK4, and CDK2 .
Increased the expression of the expression of p21 and p27.
Reduced phosphorylation of the PI3K/Akt/mTOR signaling pathway significantly.
体内研究
(In Vivo)

Rhodiolin (10-25 mg/kg, i.g., 每两天一次共 10 天) 可显著抑制 BALB/c 裸鼠人甲状腺乳头状癌异种移植模型中的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MH-134 hepatoma xenograft model established in 6 weeks old female C57BL/6 mice[1]
Dosage: 10 and 25 mg/kg
Administration: Intragastric administration (i.g.), every two days for 10 days
Result: Reduced the tumor-cell density significantly.
Showed a dose-dependent reduction in the number of Ki-67-positive cells and GPI expression.
Induced significant apoptosis in tumor tissue.
No signs of hepatotoxicity were evident.
No morphological abnormalities or signs of inflammation were detected in the heart, liver, spleen, lungs, or kidneys of mice.
分子量

480.42

Formula

C25H20O10
CAS 号
性状

固体

颜色

Light yellow to yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

Rhodiolin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rhodiolin86831-53-0Glucose-6-Phosphate Isomerase (GPI)Casein KinaseVirus ProteaseFlavivirusPI3KAktmTORApoptosisGlucose-6-Phosphate IsomerasePhosphoinositide 3-kinasePKBProtein kinase BMammalian target of RapamycinPapillary thyroid cancerGlucose 6-phosphate isomeraseGlycolysisCasein kinase I isoform epsilonPhytoconstituentsVirtual screeningMolecular dynamic simulationsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Rhodiolin
目录号：
HY-N6841
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z