2. Epigenetics PI3K/Akt/mTOR JAK/STAT Signaling Stem Cell/Wnt Autophagy
  3. AMPK STAT Autophagy
  4. RSVA405

RSVA405 是一种有效和具有口服活性的 AMPK 激活剂，EC50 值为 1 μM。RSVA405 通过促进 CaMKKβ 依赖的 AMPK 活化，从而抑制 mTOR，并促进自噬 (autophagy) 以增加 Aβ 的降解。RSVA405 通过抑制 STAT3 功能具有抗炎作用。RSVA405 也可用于肥胖症的研究。

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RSVA405 Chemical Structure

RSVA405 Chemical Structure

CAS No. : 140405-36-3

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥990
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5 mg ￥900
In-stock
10 mg ￥1500
In-stock
25 mg ￥3400
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50 mg ￥4900
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

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Customer Review

RSVA405 相关抗体

Top Publications Citing Use of Products

查看 AMPK 亚型特异性产品:

查看所有亚型
NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity[1][2][3][4].

IC50 & Target[2]

AMPK

1 μM (EC50, in cell-based assays)

体外研究
(In Vitro)

RSVA405 (0.2-2 μM; 24 h) inhibits adipocyte differentiation[2].
RSVA405 (0.2-2 μM; 24 h) significantly inhibits the expression of peroxisome proliferator-activated receptor (PPAR)-γ, fatty acid synthase (FAS) and fatty acid binding protein 4 (aP2) in 3T3-L1 cells[2].
RSVA405 (1-3 μM; 16 h) inhibits LPS-induced STAT3 activity, intracellular signaling, and cytokine response in activated RAW 264.7 macrophages[3].
RSVA405 (1-3 μM; 24 h) inhibits mTOR, induces autophagy, and facilitates the lysosomal degradation of Aβ, with an EC50 of ∼1 μM in APP-HEK293 cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RSVA405 相关抗体:

Cell Viability Assay[2]

Cell Line: 3T3-L1 preadipocytes
Concentration: 0.2, 0.5, 1, 2 μM
Incubation Time: 24 h
Result: Increased the phosphorylation of AMPK and its substrate acetyl-CoA carboxylase (ACC).
Inhibited the accumulation of lipid droplets in a dose-dependent manner, with an IC50 of 0.5 μM.
体内研究
(In Vivo)

RSVA405 (3 mg/kg; i.p.) attenuates renal injury and protects renal function after ischemia-reperfusion (I/R) in rats[1].
RSVA405 (20-100 mg/kg/d; p.o. for 11 weeks) significantly reduces the body weight gain of mice fed a high-fat diet[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (300-350 g) are induced I/R injury[1]
Dosage: 3 mg/kg
Administration: I.p. one hour before inducing I/R injury
Result: Decreased the levels of creatinine and blood urea nitrogen (BUN), by 35.8% and 44.3% in serum, respectively.
Decreased the levels of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) by 33.0% and 59.8% in serum, respectively.
分子量

312.37

Formula

C17H20N4O2
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 116.67 mg/mL (373.50 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.2013 mL 16.0067 mL 32.0133 mL
5 mM 0.6403 mL 3.2013 mL 6.4027 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.72%

COA (284 KB) HNMR (244 KB) LCMS (94 KB)

产品使用指南 (1538 KB)
参考文献

RSVA405 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2013 mL 16.0067 mL 32.0133 mL 80.0333 mL
5 mM 0.6403 mL 3.2013 mL 6.4027 mL 16.0067 mL
10 mM 0.3201 mL 1.6007 mL 3.2013 mL 8.0033 mL
15 mM 0.2134 mL 1.0671 mL 2.1342 mL 5.3356 mL
20 mM 0.1601 mL 0.8003 mL 1.6007 mL 4.0017 mL
25 mM 0.1281 mL 0.6403 mL 1.2805 mL 3.2013 mL
30 mM 0.1067 mL 0.5336 mL 1.0671 mL 2.6678 mL
40 mM 0.0800 mL 0.4002 mL 0.8003 mL 2.0008 mL
50 mM 0.0640 mL 0.3201 mL 0.6403 mL 1.6007 mL
60 mM 0.0534 mL 0.2668 mL 0.5336 mL 1.3339 mL
80 mM 0.0400 mL 0.2001 mL 0.4002 mL 1.0004 mL
100 mM 0.0320 mL 0.1601 mL 0.3201 mL 0.8003 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RSVA405140405-36-3RSVA 405RSVA-405AMPKSTATAutophagyAMP-activated protein kinaseAMP-ActivatedProteinKinaseanti-inflammatorySTAT3obesityAlzheimer'sdiseaseI/RInhibitorinhibitorinhibit

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