20(R)-Ginsenoside Rh2 (Synonyms: 20(R)-人参皂苷Rh2)

目录号: HY-N1401 纯度: ≥98.0%: FAQs
Data Sheet SDS COA 产品使用指南技术支持

20(R)-Ginsenoside Rh2，基质金属蛋白酶 (MMP) 抑制剂，作为细胞抗增殖剂。它通过阻断细胞增殖和引起 G1 期阻滞而具有抗癌作用。20(R)-Ginsenoside Rh2 诱导细胞凋亡并具有抗炎和抗氧化活性。20(R)-Ginsenoside Rh2 抑制小鼠和人 γ 疱疹病毒 68 (MHV-68) 的复制和增殖，对鼠 MHV-68 的 IC₅₀ 为 2.77 μM。

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20(R)-Ginsenoside Rh2 Chemical Structure

CAS No. : 112246-15-8

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5 mg	￥1160	In-stock
10 mg	￥1740	In-stock
25 mg	￥3100	In-stock
50 mg	￥4713	In-stock
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Other Forms of 20(R)-Ginsenoside Rh2:

20(R)-Ginsenoside Rh2 (Standard) 询价

MCE 顾客使用本产品发表的 1 篇科研文献

•Sci Adv. 2023 Jan 20;9(3):eadd3867. [Abstract]

20(R)-Ginsenoside Rh2 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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HSV-1 HSV-2 HSV

生物活性
纯度 & 产品资料
参考文献

生物活性

20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity^[1]^[2]^[3]. 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gammaherpesvirus 68 (MHV-68) with an IC₅₀ of 2.77 μM for murine MHV-68^[4].

IC₅₀ & Target

MMP^[1]

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	38 μM Compound: Rh2	Antiproliferative activity against human DU-145 cells incubated for 3 days Antiproliferative activity against human DU-145 cells incubated for 3 days	[PMID: 32702586]
HCT-116	IC₅₀	19.6 μM Compound: Rh2	Cytotoxicity against human HCT-116 assessed as reduction in cell viability by MTT assay Cytotoxicity against human HCT-116 assessed as reduction in cell viability by MTT assay	[PMID: 32702586]
HCT-116	IC₅₀	35 μM Compound: Rh2	Induction of cell death in human HCT-116 cells incubated for 48 hrs by trypan blue staining based analysis Induction of cell death in human HCT-116 cells incubated for 48 hrs by trypan blue staining based analysis	[PMID: 32702586]
HeLa	IC₅₀	2.52 μg/mL Compound: Rh2	Induction of apoptosis in human HeLa cells incubated for 2 hrs by fluorescence microscopic analysis Induction of apoptosis in human HeLa cells incubated for 2 hrs by fluorescence microscopic analysis	[PMID: 32702586]
HepG2	IC₅₀	1.648 μg/mL Compound: Rh2	Induction of apoptosis in human HepG2 cells incubated for 72 hrs Induction of apoptosis in human HepG2 cells incubated for 72 hrs	[PMID: 32702586]
HepG2	IC₅₀	100 μM Compound: Rh2	Induction of apoptosis in human HepG2 cells incubated for 48 hrs by PI/Annexin V-FITC analysis Induction of apoptosis in human HepG2 cells incubated for 48 hrs by PI/Annexin V-FITC analysis	[PMID: 32702586]
HepG2	IC₅₀	129.2 μM Compound: Rh2	Induction of apoptosis in human HepG2 beta-catenin cells incubated for 48 hrs by PI/Annexin V-FITC analysis Induction of apoptosis in human HepG2 beta-catenin cells incubated for 48 hrs by PI/Annexin V-FITC analysis	[PMID: 32702586]
HepG2	IC₅₀	42.12 μM Compound: Rh2	Induction of apoptosis in human HepG2 cells incubated for 24 hrs Induction of apoptosis in human HepG2 cells incubated for 24 hrs	[PMID: 32702586]
HepG2	IC₅₀	58.12 μM Compound: Rh2	Induction of apoptosis in human HepG2 cells incubated for 72 hrs by PI/Annexin V-FITC analysis Induction of apoptosis in human HepG2 cells incubated for 72 hrs by PI/Annexin V-FITC analysis	[PMID: 32702586]
HepG2	IC₅₀	83.33 μM Compound: Rh2	Induction of apoptosis in human HepG2 beta-catenin cells incubated for 72 hrs by PI/Annexin V-FITC analysis Induction of apoptosis in human HepG2 beta-catenin cells incubated for 72 hrs by PI/Annexin V-FITC analysis	[PMID: 32702586]
HL-60	IC₅₀	25.59 μM Compound: Rh2	Induction of apoptosis in human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Induction of apoptosis in human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 32702586]
HL-60	IC₅₀	38 μM Compound: Rh2	Cytotoxicity against human HL-60 cells measured after 24 hrs by MTT assay Cytotoxicity against human HL-60 cells measured after 24 hrs by MTT assay	[PMID: 32702586]
Jurkat	IC₅₀	35 μM Compound: Rh2	Inhibition of proliferation in human Jurkat cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Inhibition of proliferation in human Jurkat cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 32702586]
K562	IC₅₀	60 μM Compound: Rh2	Cytotoxicity against human K562 cells incubated for 48 hrs by CCK-8 assay Cytotoxicity against human K562 cells incubated for 48 hrs by CCK-8 assay	[PMID: 32702586]
Kasumi 1	IC₅₀	60.06 μM Compound: Rh2	Induction of apoptosis in human Kasumi 1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Induction of apoptosis in human Kasumi 1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 32702586]
KG-1	IC₅₀	60 μM Compound: Rh2	Cytotoxicity against human KG-1 alpha cells incubated for 48 hrs by CCK-8 assay Cytotoxicity against human KG-1 alpha cells incubated for 48 hrs by CCK-8 assay	[PMID: 32702586]
LNCaP	IC₅₀	17 μM Compound: Rh2	Antiproliferative activity against human LNCaP cells incubated for 3 days Antiproliferative activity against human LNCaP cells incubated for 3 days	[PMID: 32702586]
PC-3	IC₅₀	35 μM Compound: Rh2	Antiproliferative activity against human PC-3 cells incubated for 3 days Antiproliferative activity against human PC-3 cells incubated for 3 days	[PMID: 32702586]
SK-HEP1	IC₅₀	3.15 μg/mL Compound: Rh2	Induction of apoptosis in human SK-HEP1 cells incubated for 2 hrs by fluorescence microscopic analysis Induction of apoptosis in human SK-HEP1 cells incubated for 2 hrs by fluorescence microscopic analysis	[PMID: 32702586]
SW480	IC₅₀	35 μM Compound: Rh2	Induction of cell death in human SW480 cells incubated for 48 hrs by trypan blue staining based analysis Induction of cell death in human SW480 cells incubated for 48 hrs by trypan blue staining based analysis	[PMID: 32702586]
SW480	IC₅₀	4.06 μg/mL Compound: Rh2	Induction of apoptosis in human SW480 cells incubated for 2 hrs by fluorescence microscopic analysis Induction of apoptosis in human SW480 cells incubated for 2 hrs by fluorescence microscopic analysis	[PMID: 32702586]
U-937	IC₅₀	38 μM Compound: Rh2	Cytotoxicity against human U-937 cells measured after 24 hrs by MTT assay Cytotoxicity against human U-937 cells measured after 24 hrs by MTT assay	[PMID: 32702586]

分子量

622.87

Formula

C₃₆H₆₂O₈

CAS 号

112246-15-8

性状

固体

颜色

White to off-white

中文名称

20(R)-人参皂苷Rh2

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

细胞实验：

DMSO 中的溶解度 : 125 mg/mL (200.68 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6055 mL	8.0274 mL	16.0547 mL
5 mM	0.3211 mL	1.6055 mL	3.2109 mL
10 mM	0.1605 mL	0.8027 mL	1.6055 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: ≥98.0%

选择批次：

Data Sheet (603 KB) SDS (251 KB)

COA (266 KB) HNMR (239 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Choi WY, et al. Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes. J Pharm Pharmacol. 2013 Feb;65(2):310-6. [Content Brief]

[2]. Chung KS, et al. Ginsenoside Rh2 induces cell cycle arrest and differentiation in human leukemia cells by upregulating TGF-β expression. Carcinogenesis. 2013 Feb;34(2):331-40. [Content Brief]

[3]. Choi S, et al. Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases. Pharm Res. 2009 Oct;26(10):2280-8. [Content Brief]

[4]. Kang S, et al. Antiviral activity of 20(R)-ginsenoside Rh2 against murine gammaherpesvirus. J Ginseng Res. 2017 Oct;41(4):496-502. [Content Brief]

20(R)-Ginsenoside Rh2 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6055 mL	8.0274 mL	16.0547 mL	40.1368 mL
	5 mM	0.3211 mL	1.6055 mL	3.2109 mL	8.0274 mL
	10 mM	0.1605 mL	0.8027 mL	1.6055 mL	4.0137 mL
	15 mM	0.1070 mL	0.5352 mL	1.0703 mL	2.6758 mL
	20 mM	0.0803 mL	0.4014 mL	0.8027 mL	2.0068 mL
	25 mM	0.0642 mL	0.3211 mL	0.6422 mL	1.6055 mL
	30 mM	0.0535 mL	0.2676 mL	0.5352 mL	1.3379 mL
	40 mM	0.0401 mL	0.2007 mL	0.4014 mL	1.0034 mL
	50 mM	0.0321 mL	0.1605 mL	0.3211 mL	0.8027 mL
	60 mM	0.0268 mL	0.1338 mL	0.2676 mL	0.6689 mL
	80 mM	0.0201 mL	0.1003 mL	0.2007 mL	0.5017 mL
	100 mM	0.0161 mL	0.0803 mL	0.1605 mL	0.4014 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

20(R)-Ginsenoside Rh2112246-15-820(R)-人参皂苷Rh2MMPApoptosisHSVMatrix metalloproteinasesHerpes simplex virusInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

20(R)-Ginsenoside Rh2 (Synonyms: 20(R)-人参皂苷Rh2)

Customer Review

Other Forms of 20(R)-Ginsenoside Rh2:

MCE 顾客使用本产品发表的 1 篇科研文献