9-Hydroxycalabaxanthone (Synonyms: Xanthone I)

目录号: HY-N2795 纯度: 99.14%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

9-Hydroxycalabaxanthone (Xanthone I) 是一种黄酮类物质，从 Garcinia mangostana 中分离得到的。9-Hydroxycalabaxanthone 具有群体感抑菌、抗菌和抗疟活性 (IC₅₀=1.2-1.5 μM)。

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9-Hydroxycalabaxanthone Chemical Structure

CAS No. : 35349-68-9

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规格	价格	是否有货
1 mg	￥1200	In-stock
5 mg	￥5200	In-stock
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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

生物活性
纯度 & 产品资料
参考文献

生物活性

9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC₅₀=1.2-1.5 μM)^[1].

IC₅₀ & Target

Plasmodium

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
ASPC1	IC₅₀	25.49 μM Compound: 12a	Cytotoxicity against human AsPC1 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human AsPC1 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]
B16-F10	IC₅₀	26.17 μM Compound: 12a	Cytotoxicity against mouse B16F10 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against mouse B16F10 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]
HeLa S3	IC₅₀	1.9 μM Compound: 26	Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
HepG2	IC₅₀	3.4 μM Compound: 26	Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
HT-29	IC₅₀	1.6 μM Compound: 26	Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
KB	IC₅₀	1.7 μM Compound: 26	Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
MCF7	IC₅₀	1.9 μM Compound: 26	Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
MCF7	IC₅₀	3.9 μg/mL Compound: 5	Cytotoxicity against human MCF7 cells assessed as [3H]hypoxanthin incorporation after 24 to 72 hrs Cytotoxicity against human MCF7 cells assessed as [3H]hypoxanthin incorporation after 24 to 72 hrs	[PMID: 19296616]
MDA-MB-231	IC₅₀	21.06 μM Compound: 12a	Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]
NCI-H460	IC₅₀	19.69 μM Compound: 12a	Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]
RAW264.7	IC₅₀	18.6 μM Compound: 8	Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay	[PMID: 31860303]
SW-620	IC₅₀	26.14 μM Compound: 12a	Cytotoxicity against human SW620 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay Cytotoxicity against human SW620 cells assessed as inhibition of cell proliferation after 48 hrs by XTT assay	[PMID: 24717154]

体外研究
(In Vitro)

9-Hydroxycalabaxanthone inhibits the activities of 3D7 and K1 P. falciparum clones with IC₅₀ values of 1.5 μM and 1.2 μM, respectively^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

408.44

Formula

C₂₄H₂₄O₆

CAS 号

35349-68-9

性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

细胞实验：

DMSO 中的溶解度 : 50 mg/mL (122.42 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4483 mL	12.2417 mL	24.4834 mL
5 mM	0.4897 mL	2.4483 mL	4.8967 mL
10 mM	0.2448 mL	1.2242 mL	2.4483 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.14%

选择批次：

Data Sheet (601 KB) SDS (251 KB)

COA (173 KB) HNMR (131 KB) LCMS (245 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Gamal A Mohamed, et al. Mangostanaxanthones I and II, New Xanthones From the Pericarp of Garcinia Mangostana. Fitoterapia. 2014 Oct;98:215-21. [Content Brief]

[2]. Wanna Chaijaroenkul, et al. The in Vitro Antimalarial Interaction of 9-hydroxycalabaxanthone and α-mangostin With mefloquine/artesunate. Acta Parasitol. 2014 Mar;60(1):105-11. [Content Brief]

9-Hydroxycalabaxanthone 相关分类

Infection

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4483 mL	12.2417 mL	24.4834 mL	61.2085 mL
	5 mM	0.4897 mL	2.4483 mL	4.8967 mL	12.2417 mL
	10 mM	0.2448 mL	1.2242 mL	2.4483 mL	6.1209 mL
	15 mM	0.1632 mL	0.8161 mL	1.6322 mL	4.0806 mL
	20 mM	0.1224 mL	0.6121 mL	1.2242 mL	3.0604 mL
	25 mM	0.0979 mL	0.4897 mL	0.9793 mL	2.4483 mL
	30 mM	0.0816 mL	0.4081 mL	0.8161 mL	2.0403 mL
	40 mM	0.0612 mL	0.3060 mL	0.6121 mL	1.5302 mL
	50 mM	0.0490 mL	0.2448 mL	0.4897 mL	1.2242 mL
	60 mM	0.0408 mL	0.2040 mL	0.4081 mL	1.0201 mL
	80 mM	0.0306 mL	0.1530 mL	0.3060 mL	0.7651 mL
	100 mM	0.0245 mL	0.1224 mL	0.2448 mL	0.6121 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

9-Hydroxycalabaxanthone35349-68-9Xanthone IParasiteBacterialAntimalarial,quorum-sensingK1 P. falciparum3D7 P. falciparumInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

9-Hydroxycalabaxanthone (Synonyms: Xanthone I)

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