Geldanamycin (Synonyms: 格尔德霉素)

目录号: HY-15230 纯度: 99.78%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Geldanamycin是 Hsp90 抑制剂，具有抗许多革兰氏阳性和一些革兰氏阴性细菌的活性。Geldanamycin 还具有抗流感病毒 H5N1 的活性。

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Geldanamycin Chemical Structure

CAS No. : 30562-34-6

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥1544	In-stock
1 mg	￥500	In-stock
5 mg	￥1234	In-stock
10 mg	￥1989	In-stock
25 mg	￥3282	In-stock
50 mg	￥4595	In-stock
100 mg	现货	询价
200 mg		询价
500 mg		询价

or 大包装询价

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Customer Review

Other Forms of Geldanamycin:

Geldanamycin (Standard) 询价

MCE 顾客使用本产品发表的 25 篇科研文献

: Geldanamycin purchased from MCE. Usage Cited in: J Cell Biochem. 2019 Sep;120(9):16254-16263. [Abstract]; Caspase 3, caspase 9, cleaved caspase 3, cleaved caspase 9, and β-actin protein expression analyzed by Western blot with the treatment of Geldanamycin.

: Geldanamycin purchased from MCE. Usage Cited in: J Cell Biochem. 2019 Sep;120(9):16254-16263. [Abstract]; Bcl2, Bax, and β-actin protein expression is analyzed by Western blot with the treatment of Geldanamycin.

: Geldanamycin purchased from MCE. Usage Cited in: J Cell Biochem. 2018 Oct 10. [Abstract]; Geldanamycin (GA) attenuatea TNF-α-mediated activation of MAPK and NF-κB signaling pathways.

Geldanamycin 相关产品

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生物活性
纯度 & 产品资料
参考文献

生物活性

Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.

IC₅₀ & Target^[4]

HSP90

1.2 μM (Kd)

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.07 μM Compound: 1	Antiproliferative activity against human A2780 assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human A2780 assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 27476419]
A-375	IC₅₀	0.06 μM Compound: 1	Antiproliferative activity against human A375 assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human A375 assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 27476419]
A-431	IC₅₀	0.2 μM Compound: geldanamycin	Antiproliferative activity against human A431 cells after 72 hrs Antiproliferative activity against human A431 cells after 72 hrs	[PMID: 20655237]
A-431	IC₅₀	40 nM Compound: 1, GA	Cytotoxicity against human A431 cells after 72 hrs by MTT assay Cytotoxicity against human A431 cells after 72 hrs by MTT assay	[PMID: 25277067]
A549	IC₅₀	0.1 μM Compound: GA	Antiproliferative activity against human A549 cells after 72 hrs by SRB assay Antiproliferative activity against human A549 cells after 72 hrs by SRB assay	[PMID: 29172085]
A549	IC₅₀	0.109 μM Compound: Geldanamycin	Anticancer activity against human A549 cells measured after 72 hrs by SRB assay Anticancer activity against human A549 cells measured after 72 hrs by SRB assay	[PMID: 27283788]
A549	IC₅₀	0.15 μM Compound: geldanamycin	Cytotoxicity against human A549 cells after 2 days by AlamarBlue assay Cytotoxicity against human A549 cells after 2 days by AlamarBlue assay	[PMID: 23947794]
A549	IC₅₀	0.99 μM Compound: GDM	Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay	[PMID: 32663707]
A549	IC₅₀	97 nM Compound: 1, GA	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 25277067]
BGC-823	IC₅₀	0.11 μM Compound: 1	Antiproliferative activity against human BGC823 assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human BGC823 assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 27476419]
BGC-823	IC₅₀	40 nM Compound: 1, GA	Cytotoxicity against human BGC823 cells after 72 hrs by MTT assay Cytotoxicity against human BGC823 cells after 72 hrs by MTT assay	[PMID: 25277067]
CAKI-1	IC₅₀	0.056 μM Compound: Geldanamycin	Anticancer activity against human Caki1 cells measured after 72 hrs by SRB assay Anticancer activity against human Caki1 cells measured after 72 hrs by SRB assay	[PMID: 27283788]
CNE2Z	IC₅₀	0.31 μM Compound: GM	Antiproliferative activity against human CNE2Z cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human CNE2Z cells assessed as cell growth inhibition by MTT assay	[PMID: 32527461]
HCT-116	EC₅₀	0.03 μM Compound: 1	Antiproliferative activity against human HCT116 cells measured on day 4 by Cell titer-glo assay Antiproliferative activity against human HCT116 cells measured on day 4 by Cell titer-glo assay	[PMID: 21420297]
HCT-116	EC₅₀	0.03 μM Compound: 1	Antiproliferative activity against human HCT116 cells by luminescence assay Antiproliferative activity against human HCT116 cells by luminescence assay	[PMID: 21605975]
HCT-116	IC₅₀	0.1 μM Compound: 1	Antiproliferative activity against human HCT116 assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human HCT116 assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 27476419]
HCT-116	IC₅₀	0.15 μM Compound: Geldanamycin	Anticancer activity against human HCT116 cells measured after 72 hrs by SRB assay Anticancer activity against human HCT116 cells measured after 72 hrs by SRB assay	[PMID: 27283788]
HeLa	IC₅₀	> 5 μM Compound: Geldanamycin	Cytotoxicity against human HeLa cells at 72 hrs by MTS assay Cytotoxicity against human HeLa cells at 72 hrs by MTS assay	[PMID: 22162786]
HeLa	IC₅₀	0.06 μM Compound: GA	Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay	[PMID: 27266997]
HeLa	IC₅₀	798 nM Compound: 1, GA	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 25277067]
HepG2	IC₅₀	0.3 μM Compound: GDM	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 23656556]
HepG2	IC₅₀	1.74 μM Compound: GM	Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition by MTT assay	[PMID: 32527461]
HepG2	IC₅₀	40 nM Compound: 1, GA	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 25277067]
Huh-7	EC₅₀	0.25 nM Compound: Geldanamycin	Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days by qRT-PCR analysis Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days by qRT-PCR analysis	[PMID: 18936191]
Huh-7	EC₅₀	1.2 nM Compound: Geldanamycin	Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days selected with 40 nM HCV-796 and 800 nM boceprevir by qRT-PCR analysis Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days selected with 40 nM HCV-796 and 800 nM boceprevir by qRT-PCR analysis	[PMID: 18936191]
HUVEC	IC₅₀	19 nM Compound: 1, GA	Cytotoxicity against HUVEC cells after 72 hrs by MTT assay Cytotoxicity against HUVEC cells after 72 hrs by MTT assay	[PMID: 25277067]
L02	IC₅₀	141 nM Compound: 1, GA	Cytotoxicity against human HL7702 cells after 72 hrs by MTT assay Cytotoxicity against human HL7702 cells after 72 hrs by MTT assay	[PMID: 25277067]
L6	IC₅₀	6 μM Compound: GA	Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay	[PMID: 24580531]
LNCaP	IC₅₀	0.43 μM Compound: GA	Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 25105924]
LS174T	IC₅₀	0.45 μM Compound: GA	Cytotoxicity against human LS174T cells by MTS assay Cytotoxicity against human LS174T cells by MTS assay	[PMID: 17034135]
MCF7	IC₅₀	0.04 μM Compound: GDA	Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay	[PMID: 25075762]
MCF7	IC₅₀	0.0427 μM Compound: 1, GDA	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay	[PMID: 25756299]
MCF7	IC₅₀	0.053 μM Compound: Geldanamycin	Cytotoxicity against human MCF7 cells at 72 hrs by MTS assay Cytotoxicity against human MCF7 cells at 72 hrs by MTS assay	[PMID: 22162786]
MCF7	IC₅₀	0.11 μM Compound: 1	Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 27476419]
MCF7	GI₅₀	35.6 μM Compound: geldanamycin	Growth inhibition of human MCF7 cells after days by SRB assay Growth inhibition of human MCF7 cells after days by SRB assay	[PMID: 17869098]
MCF7	IC₅₀	9.6 μM Compound: Geldanamycin	Cytotoxicity against human MCF7 cells by SRB assay Cytotoxicity against human MCF7 cells by SRB assay	[PMID: 19560353]
MCF7	IC₅₀	9.8 nM Compound: 5, GDA	Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 72 hrs Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 72 hrs	[PMID: 23648180]
MDA-MB-231	IC₅₀	0.03 μM Compound: GA	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay	[PMID: 27266997]
MDA-MB-231	IC₅₀	0.05 μM Compound: 1, GA	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 25277067]
MDA-MB-231	IC₅₀	0.05 μM Compound: GA	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 25105924]
MDA-MB-231	IC₅₀	0.06 μM Compound: GA	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay	[PMID: 29172085]
MDA-MB-231	IC₅₀	0.11 μM Compound: Geldanamycin	Anticancer activity against human MDA-MB-231 cells measured after 72 hrs by SRB assay Anticancer activity against human MDA-MB-231 cells measured after 72 hrs by SRB assay	[PMID: 27283788]
MDA-MB-231	IC₅₀	0.62 μM Compound: GM	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition by MTT assay	[PMID: 32527461]
NCI-H1975	GI₅₀	0.56 μM Compound: 1; GA	Antiproliferative activity against gefitinib-resistant human NCI-H1975 cells after 1 to 3 days by MTS assay Antiproliferative activity against gefitinib-resistant human NCI-H1975 cells after 1 to 3 days by MTS assay	[PMID: 27783977]
NCI-H1975	GI₅₀	0.56 μM Compound: GA	Antiproliferative activity against human NCI-H1975 cells after 72 hrs by Cell Titer 96 Aqueous One Solution cell proliferation assay Antiproliferative activity against human NCI-H1975 cells after 72 hrs by Cell Titer 96 Aqueous One Solution cell proliferation assay	[PMID: 29202402]
P19	IC₅₀	0.1 μM Compound: 1	Cytotoxicity against mouse P19 cells after 18 hrs Cytotoxicity against mouse P19 cells after 18 hrs	[PMID: 17442565]
PC-3	IC₅₀	0.73 μM Compound: GDM	Antiproliferative activity against human PC-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay Antiproliferative activity against human PC-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay	[PMID: 32663707]
RPMI-8226	GI₅₀	0.003 μM Compound: Geldanamycin	Growth inhibition of human RPMI8226 cells after 72 hrs by MTS/PMS assay Growth inhibition of human RPMI8226 cells after 72 hrs by MTS/PMS assay	[PMID: 29057043]
Sf9	IC₅₀	74 nM Compound: Geldanamycin	Displacement of GM-BODIPY from human full length HSP90 alpha expressed in baculovirus-infected Sf9 cells after 16 hrs by fluorescence polarization assay Displacement of GM-BODIPY from human full length HSP90 alpha expressed in baculovirus-infected Sf9 cells after 16 hrs by fluorescence polarization assay	[PMID: 24751441]
SK-BR-3	GI₅₀	0.43 μM Compound: 1; GA	Antiproliferative activity against Her2-overexpressing human SKBR3 cells after 1 to 3 days by MTS assay Antiproliferative activity against Her2-overexpressing human SKBR3 cells after 1 to 3 days by MTS assay	[PMID: 27783977]
SK-BR-3	IC₅₀	0.87 μM Compound: GDM	Antiproliferative activity against human SK-BR-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay Antiproliferative activity against human SK-BR-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay	[PMID: 32663707]
SK-BR-3	IC₅₀	41 nM Compound: GDM	Cytotoxicity against human SKBR3 cells after 72 hrs by celltiter-glo assay Cytotoxicity against human SKBR3 cells after 72 hrs by celltiter-glo assay	[PMID: 19405528]
SK-BR-3	IC₅₀	8.5 nM Compound: 5, GDA	Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 72 hrs Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 72 hrs	[PMID: 23648180]
SK-OV-3	IC₅₀	0.94 μM Compound: GDM	Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay	[PMID: 32663707]
SMMC-7721	IC₅₀	0.11 μM Compound: GM	Antiproliferative activity against human SMMC7721 cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human SMMC7721 cells assessed as cell growth inhibition by MTT assay	[PMID: 32527461]
SNU-638	IC₅₀	0.03 μM Compound: Geldanamycin	Anticancer activity against human SNU638 cells measured after 72 hrs by SRB assay Anticancer activity against human SNU638 cells measured after 72 hrs by SRB assay	[PMID: 27283788]
SW1990	IC₅₀	0.29 μM Compound: 1	Antiproliferative activity against human SW1990 assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human SW1990 assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 27476419]
SW480	IC₅₀	0.51 μM Compound: GM	Antiproliferative activity against human SW480 cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human SW480 cells assessed as cell growth inhibition by MTT assay	[PMID: 32527461]
SW480	IC₅₀	310 nM Compound: 1, GA	Cytotoxicity against human SW480 cells after 72 hrs by MTT assay Cytotoxicity against human SW480 cells after 72 hrs by MTT assay	[PMID: 25277067]
U-87MG ATCC	EC₅₀	0.089 μM Compound: 1	Antiproliferative activity against human U87 cells by luminescence assay Antiproliferative activity against human U87 cells by luminescence assay	[PMID: 21605975]
U-87MG ATCC	IC₅₀	0.81 μM Compound: GDM	Antiproliferative activity against human U-87 MG cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay Antiproliferative activity against human U-87 MG cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay	[PMID: 32663707]

体外研究
(In Vitro)

Geldanamycin 显著延迟和降低 viperin 表达，表明 IRF3 参与 RAW264.7 细胞中的 viperin 诱导^[1]。
Geldanamycin 是一种苯醌安沙霉素，可防止在培养的原代神经元中由氧-葡萄糖剥夺 (OGD)/zVAD 处理诱导的神经元损伤。更重要的是，Geldanamycin 以时间和浓度依赖性方式降低 RIP1 蛋白水平。Geldanamycin 还会降低 Hsp90 蛋白水平，从而导致 RIP1 蛋白不稳定，导致 Geldanamycin 处理后 RIP1 蛋白水平降低，但 RIP1 mRNA 水平没有降低^[2]。
Geldanamycin 被确定为第一个 Hsp90 的天然产物抑制剂，它结合 Hsp90 的 N 端 ATPase 结构域以抑制其分子伴侣功能，并通过凋亡机制显著诱导肿瘤细胞死亡^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

560.64

Formula

C₂₉H₄₀N₂O₉

CAS 号

30562-34-6

性状

固体

颜色

Light yellow to orange

中文名称

格尔德霉素

结构分类

初始来源

微生物

Streptomyces hygroscopicus

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 25 mg/mL (44.59 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7837 mL	8.9184 mL	17.8368 mL
5 mM	0.3567 mL	1.7837 mL	3.5674 mL
10 mM	0.1784 mL	0.8918 mL	1.7837 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (4.46 mM); 悬浊液; 超声助溶

此方案可获得 2.5 mg/mL的均匀悬浊液，悬浊液可用于口服和腹腔注射。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (4.46 mM); 悬浊液; 超声助溶

此方案可获得 2.5 mg/mL的均匀悬浊液，悬浊液可用于口服和腹腔注射。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.78%

选择批次：

Data Sheet (652 KB) SDS (393 KB)

COA (206 KB) HNMR (204 KB) LCMS (446 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Tang HB, et al. Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4. Sci Rep. 2016 Jul 26;6:30529 [Content Brief]

[2]. Chen WW, et al. RIP1 mediates the protection of Geldanamycin on neuronal injury induced by oxygen-glucosedeprivation combined with zVAD in primary cortical neurons. J Neurochem. 2012 Jan;120(1):70-7. [Content Brief]

[3]. Lin Z, et al. 17-ABAG, a novel Geldanamycin derivative, inhibits LNCaP-cell proliferation through heat shock protein 90 inhibition. Int J Mol Med. 2015 Aug;36(2):424-32. [Content Brief]

[4]. Roe SM, et al. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J Med Chem. 1999 Jan 28;42(2):260-6. [Content Brief]

[5]. Wang C, et al. Geldanamycin Reduces Acute Respiratory Distress Syndrome and Promotes the Survival of Mice Infected with the Highly Virulent H5N1 Influenza Virus. Front Cell Infect Microbiol. 2017 Jun 15;7:267. [Content Brief]

Geldanamycin 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7837 mL	8.9184 mL	17.8368 mL	44.5919 mL
	5 mM	0.3567 mL	1.7837 mL	3.5674 mL	8.9184 mL
	10 mM	0.1784 mL	0.8918 mL	1.7837 mL	4.4592 mL
	15 mM	0.1189 mL	0.5946 mL	1.1891 mL	2.9728 mL
	20 mM	0.0892 mL	0.4459 mL	0.8918 mL	2.2296 mL
	25 mM	0.0713 mL	0.3567 mL	0.7135 mL	1.7837 mL
	30 mM	0.0595 mL	0.2973 mL	0.5946 mL	1.4864 mL
	40 mM	0.0446 mL	0.2230 mL	0.4459 mL	1.1148 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Geldanamycin30562-34-6格尔德霉素HSPBacterialInfluenza VirusAntibioticHeat shock proteinsInhibitorinhibitorinhibit

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