Neobavaisoflavone (Synonyms: 新补骨脂异黄酮)

目录号: HY-N0720 纯度: 99.92%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Neobavaisoflavone，是一种从 Psoralea corylifolia 的种子中分离出来的类黄酮。Neobavaisoflavone 具有抗炎，抗癌和抗氧化的作用。Neobavaisoflavone 在中至高浓度下可抑制 DNA 聚合酶 (DNA polymerase)。Neobavaisoflavone 也可抑制血小板聚集。

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Neobavaisoflavone Chemical Structure

CAS No. : 41060-15-5

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥550	In-stock
1 mg	￥220	In-stock
5 mg	￥500	In-stock
10 mg	￥794	In-stock
25 mg	￥1310	In-stock
50 mg	￥1834	In-stock
100 mg	￥2567	In-stock
200 mg		询价
500 mg		询价

or 大包装询价

* Please select Quantity before adding items.

Other Forms of Neobavaisoflavone:

Neobavaisoflavone (Standard) 询价

MCE 顾客使用本产品发表的 11 篇科研文献

Cell Viability Assay

: Neobavaisoflavone purchased from MCE. Usage Cited in: Phytomedicine. 2023 May 9, 154869.; Neobavaisoflavone (NBIF; 50 μM; 48 h) increases the expression of Cleaved-caspase-3 in HCCLM3 and HepG-2 cells.

: Neobavaisoflavone purchased from MCE. Usage Cited in: Phytomedicine. 2023 May 9, 154869.; Neobavaisoflavone (NBIF; 10, 20, 30, 40, 50, 60, 70, 80, 90, 100 μM; 24, 48 h) inhibits the cell viability of HCCLM3 and HepG-2 in a time- and concentration-dependent manner.

: Neobavaisoflavone purchased from MCE. Usage Cited in: Phytomedicine. 2023 May 9, 154869.; Neobavaisoflavone (NBIF; 50 μM; 48 h) severely damages mitochondria in HCCLM3 and HepG-2 cells.

Neobavaisoflavone 相关产品

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生物活性
纯度 & 产品资料
参考文献

生物活性

Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits DNA polymerase at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation^[1]^[2]^[3]^[4]^[5].

IC₅₀ & Target

DNA polymerase^[4]

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 10 μM Compound: 12	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 25710081]
K562	IC₅₀	> 10 μM Compound: 12	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 25710081]
Platelet	IC₅₀	2.5 μM Compound: 2	Antiplatelet activity against rabbit platelet assessed as inhibition of platelet-activating factor-induced platelet aggregation preincubated for 3 mins by turbidimetric method Antiplatelet activity against rabbit platelet assessed as inhibition of platelet-activating factor-induced platelet aggregation preincubated for 3 mins by turbidimetric method	[PMID: 8759164]
Platelet	IC₅₀	62.4 μM Compound: 2	Antiplatelet activity against rabbit platelet assessed as inhibition of collagen-induced platelet aggregation preincubated for 3 mins by turbidimetric method Antiplatelet activity against rabbit platelet assessed as inhibition of collagen-induced platelet aggregation preincubated for 3 mins by turbidimetric method	[PMID: 8759164]
Platelet	IC₅₀	7.8 μM Compound: 2	Antiplatelet activity against rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins by turbidimetric method Antiplatelet activity against rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins by turbidimetric method	[PMID: 8759164]

体外研究
(In Vitro)

Neobavaisoflavone (1-50 μM; 20 h) decreases NO (ED₅₀=25 μM) and cytokine (ED₅₀s=23.11, 5.03, 5.23, 5.26 and 18.80 μM for IL-1β, IL-6, IL-12p40, IL-12p70 and TNF-α, respectively) production in LPS plus IFN-γ-stimulated RAW264.7 macrophages^[1].
Neobavaisoflavone (1-100 μM; 30 min) decreases the chemiluminescence in PMA-stimulated RAW264.7 macrophages, with an ED₅₀ of 19.94 μM in activated RAW264.7 cells^[1].
Neobavaisoflavone (1-100 μM); 20 h) has no effect on the viability and is not toxic to RAW264.7 cells^[1].
Neobavaisoflavone (20-50 μM; 48 h) inhibits prostate cancer cell proliferation by inducing cytotoxicity and apoptosis in a dose-dependent manner^[2].
Neobavaisoflavone (2-8 μM; 7 d) inhibits RANKL‐mediated osteoclastogenesis in bone marrow monocytes (BMMCs) and RAW264.7 cells dose dependently at the early stage^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Neobavaisoflavone (30 mg/kg; i.p. for 6 weeks) inhibits osteoclastogenesis, promotes osteogenesis and ameliorates bone loss in ovariectomized mice^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 female mice (8 weeksd; 20-25 g) were removed bilateral ovaries^[3]
Dosage:	30 mg/kg
Administration:	I.p. for 6 weeks
Result:	Attenuated bone loss by inhibiting osteoclast activation and promoting osteogenesis in ovariectomized mice.

分子量

322.35

Formula

C₂₀H₁₈O₄

CAS 号

41060-15-5

性状

固体

颜色

White to light yellow

中文名称

新补骨脂异黄酮

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : ≥ 31 mg/mL (96.17 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1022 mL	15.5111 mL	31.0222 mL
5 mM	0.6204 mL	3.1022 mL	6.2044 mL
10 mM	0.3102 mL	1.5511 mL	3.1022 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.45 mM); 澄清溶液

此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.45 mM); 澄清溶液

此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (6.45 mM); 澄清溶液

此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.92%

选择批次：

Data Sheet (627 KB) SDS (252 KB)

COA (283 KB) HNMR (286 KB) LCMS (93 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Szliszka E, et, al. Inhibition of inflammatory mediators by neobavaisoflavone in activated RAW264.7 macrophages. Molecules. 2011 May 3;16(5):3701-12. [Content Brief]

[2]. Szliszka E, et, al. Enhanced TRAIL-mediated apoptosis in prostate cancer cells by the bioactive compounds neobavaisoflavone and psoralidin isolated from Psoralea corylifolia. Pharmacol Rep. 2011;63(1):139-48. [Content Brief]

[3]. Chen H, et, al. Neobavaisoflavone inhibits osteoclastogenesis through blocking RANKL signalling-mediated TRAF6 and c-Src recruitment and NF-κB, MAPK and Akt pathways. J Cell Mol Med. 2020 Aug;24(16):9067-9084. [Content Brief]

[4]. Sun NJ, et, al. DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia. J Nat Prod. 1998 Mar;61(3):362-6. [Content Brief]

[5]. Tsai WJ, et, al. Antiplatelet flavonoids from seeds of Psoralea corylifolia. J Nat Prod. 1996 Jul;59(7):671-2. [Content Brief]

Neobavaisoflavone 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1022 mL	15.5111 mL	31.0222 mL	77.5555 mL
	5 mM	0.6204 mL	3.1022 mL	6.2044 mL	15.5111 mL
	10 mM	0.3102 mL	1.5511 mL	3.1022 mL	7.7555 mL
	15 mM	0.2068 mL	1.0341 mL	2.0681 mL	5.1704 mL
	20 mM	0.1551 mL	0.7756 mL	1.5511 mL	3.8778 mL
	25 mM	0.1241 mL	0.6204 mL	1.2409 mL	3.1022 mL
	30 mM	0.1034 mL	0.5170 mL	1.0341 mL	2.5852 mL
	40 mM	0.0776 mL	0.3878 mL	0.7756 mL	1.9389 mL
	50 mM	0.0620 mL	0.3102 mL	0.6204 mL	1.5511 mL
	60 mM	0.0517 mL	0.2585 mL	0.5170 mL	1.2926 mL
	80 mM	0.0388 mL	0.1939 mL	0.3878 mL	0.9694 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neobavaisoflavone41060-15-5新补骨脂异黄酮ApoptosisDNA/RNA SynthesisflavonoidPsoraleacorylifoliaanti-inflammatoryanti-canceranti-oxidationDNApolymeraseplateletaggregationInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Neobavaisoflavone (Synonyms: 新补骨脂异黄酮)

Other Forms of Neobavaisoflavone:

MCE 顾客使用本产品发表的 11 篇科研文献