L-Glutamic acid (Synonyms: L-谷氨酸)

目录号: HY-14608 纯度: 99.93%: FAQs
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摩尔计算器

L-Glutamic acid 是一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型 (代谢型红藻氨酸、NMDA 和 AMPA) 的激动剂。L-Glutamic acid 对 DA 从多巴胺能神经末梢释放的过程有激动作用。L-Glutamic acid 可用于神经疾病的研究。L-Glutamic acid 作用于离子型和代谢型谷氨酸受体。

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L-Glutamic acid Chemical Structure

CAS No. : 56-86-0

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规格	价格	是否有货
10 mM * 1 mL in Water	￥440	In-stock
100 mg	￥400	In-stock
500 mg	￥600	In-stock
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5 g		询价

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Other Forms of L-Glutamic acid:

L-Glutamic acid-1-¹³C In-stock
L-Glutamic acid-¹⁵N In-stock
L-Glutamic acid-¹³C₅,¹⁵N In-stock
L-Glutamic acid-¹³C₅,¹⁵N,d₅ In-stock
L-Glutamic acid-¹³C₅ In-stock
L-Glutamic acid-d₅ In-stock
L-Glutamic acid-d₃ In-stock
L-Glutamic acid monosodium salt In-stock
L-Glutamic acid potassium salt monohydrate In-stock
L-Glutamic acid (Standard) In-stock
L-Glutamic acid-¹³C 询价
L-Glutamic acid-¹³C₂ 询价
L-Glutamic acid-14C 询价
L-Glutamic acid-5-¹³C 询价
L-Glutamic acid-¹⁵N,d₅ 询价
(S)-2-aminopentanedioic acid hydrochloride 询价
L-Glutamic acid monopotassium salt 询价

MCE 顾客使用本产品发表的 7 篇科研文献

L-Glutamic acid 相关产品

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AMPA Receptor NMDA Receptor Kainate Receptor

生物活性
纯度 & 产品资料
参考文献

生物活性

L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors^[1]^[2]^[3]^[4]^[5].

IC₅₀ & Target^[1]

Human Endogenous Metabolite

Microbial Metabolite

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
BHK-21	EC₅₀	1.8 μM Compound: (S)-Glu	Agonist activity at rat NR1/NR2A receptor expressed in BHK21 cells assessed as change in intracellular calcium levels by FLIPR assay Agonist activity at rat NR1/NR2A receptor expressed in BHK21 cells assessed as change in intracellular calcium levels by FLIPR assay	[PMID: 20408529]
CHO	EC₅₀	1.2 μM Compound: L-Glutamate	Activity at rat mGluR5 by measuring intracellular calcium concentration in CHO cells Activity at rat mGluR5 by measuring intracellular calcium concentration in CHO cells	[PMID: 16213710]
CHO	EC₅₀	153 μM Compound: 157	Cytoprotection against glutamate-induced cell death in CHO cells assessed as increase in cell viability by colorimetric assay Cytoprotection against glutamate-induced cell death in CHO cells assessed as increase in cell viability by colorimetric assay	[PMID: 29939744]
CHO	EC₅₀	16 μM Compound: 157	Agonist activity at mGlu5 receptor (unknown origin) expressed in CHO cells assessed as increase in Gq-mediated PI hydrolysis after 45 mins by yttrium scintillation proximity assay Agonist activity at mGlu5 receptor (unknown origin) expressed in CHO cells assessed as increase in Gq-mediated PI hydrolysis after 45 mins by yttrium scintillation proximity assay	[PMID: 29939744]
CHO	EC₅₀	7.3 μM Compound: L-Glutamate	Activity at rat mGluR1 by measuring intracellular calcium concentration in CHO cells Activity at rat mGluR1 by measuring intracellular calcium concentration in CHO cells	[PMID: 16213710]
CHO	EC₅₀	7.4 μM Compound: glutamate	Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human mGluR2 Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human mGluR2	[PMID: 11720869]
CHO	EC₅₀	7.6 μM Compound: L-Glutamate	Activity at rat mGluR6 by measuring cAMP formation in CHO cells Activity at rat mGluR6 by measuring cAMP formation in CHO cells	[PMID: 16213710]
HEK293	EC₅₀	> 100 μM Compound: Glutamate	Agonist activity at rat mGluR7 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay Agonist activity at rat mGluR7 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay	[PMID: 25958247]
HEK293	EC₅₀	0.06 μM Compound: Glu	Agonist activity at rat mGlu3 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assay Agonist activity at rat mGlu3 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assay	[PMID: 26814576]
HEK293	EC₅₀	1.05 μM Compound: Glutamic acid	Effect of compound on Metabotropic glutamate receptor 1 expressed in HEK 293 cells was determined by measuring IP production relative to glutamate Effect of compound on Metabotropic glutamate receptor 1 expressed in HEK 293 cells was determined by measuring IP production relative to glutamate	[PMID: 10673095]
HEK293	EC₅₀	1.6 μM Compound: Glu	Agonist activity at rat mGlu1 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assay Agonist activity at rat mGlu1 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assay	[PMID: 26814576]
HEK293	EC₅₀	1.8 μM Compound: Glu	Agonist activity at rat mGlu2 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assay Agonist activity at rat mGlu2 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assay	[PMID: 26814576]
HEK293	EC₅₀	100 μM Compound: L-Glu	Activity at rat cloned iGluR3 expressed in human HEK293 cells by calcium imaging assay Activity at rat cloned iGluR3 expressed in human HEK293 cells by calcium imaging assay	[PMID: 18338843]
HEK293	EC₅₀	110 μM Compound: (S)-Glu	Agonist activity at GluR1 E683A/M686V/I687A mutant expressed in HEK293 cells by Fluo-4/Ca2+ assay Agonist activity at GluR1 E683A/M686V/I687A mutant expressed in HEK293 cells by Fluo-4/Ca2+ assay	[PMID: 17672447]
HEK293	EC₅₀	12.57 μM Compound: Glutamate	Agonist activity at rat mGluR4 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay Agonist activity at rat mGluR4 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay	[PMID: 25958247]
HEK293	EC₅₀	13.08 μM Compound: Glu	Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay	[PMID: 26814576]
HEK293	EC₅₀	13.65 μM Compound: Glutamate	Agonist activity at rat mGluR5 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay Agonist activity at rat mGluR5 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay	[PMID: 25958247]
HEK293	EC₅₀	13.87 μM Compound: Glu	Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay	[PMID: 26814576]
HEK293	EC₅₀	130 μM Compound: L-Glu	Activity at rat cloned iGluR5 expressed in human HEK293 cells by calcium imaging assay Activity at rat cloned iGluR5 expressed in human HEK293 cells by calcium imaging assay	[PMID: 18338843]
HEK293	EC₅₀	14.01 μM Compound: Glu	Agonist activity at rat mGlu8 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay Agonist activity at rat mGlu8 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay	[PMID: 26814576]
HEK293	EC₅₀	140 μM Compound: Glu	Agonist activity at rat recombinant GluR5(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay Agonist activity at rat recombinant GluR5(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	[PMID: 19588945]
HEK293	EC₅₀	140 μM Compound: L-Glu	Activity at rat cloned iGluR2 expressed in human HEK293 cells by calcium imaging assay Activity at rat cloned iGluR2 expressed in human HEK293 cells by calcium imaging assay	[PMID: 18338843]
HEK293	EC₅₀	140 μM Compound: (S)-Glu	Agonist activity at GluR2Q expressed in HEK293 cells by Fluo-4/Ca2+ assay Agonist activity at GluR2Q expressed in HEK293 cells by Fluo-4/Ca2+ assay	[PMID: 17672447]
HEK293	EC₅₀	140 μM Compound: (S)-Glu	Agonist activity at GluR1 I687A mutant expressed in HEK293 cells by Fluo-4/Ca2+ assay Agonist activity at GluR1 I687A mutant expressed in HEK293 cells by Fluo-4/Ca2+ assay	[PMID: 17672447]
HEK293	EC₅₀	16 μM Compound: 33032	Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells	10.5281/zenodo.6782621
HEK293	EC₅₀	17 μM Compound: L-Glu	Activity at rat cloned iGluR4 expressed in human HEK293 cells by calcium imaging assay Activity at rat cloned iGluR4 expressed in human HEK293 cells by calcium imaging assay	[PMID: 18338843]
HEK293	EC₅₀	18.25 μM Compound: Glutamate	Agonist activity at rat mGluR2 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay Agonist activity at rat mGluR2 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay	[PMID: 25958247]
HEK293	EC₅₀	190 μM Compound: (S)-Glutamate	Agonist activity at rat recombinant GluA2 receptor flip isoform expressed in HEK293 cells assessed as effect on cyclothiazide-induced calcium flux by Fluo-4/AM staining-based fluorescence assay Agonist activity at rat recombinant GluA2 receptor flip isoform expressed in HEK293 cells assessed as effect on cyclothiazide-induced calcium flux by Fluo-4/AM staining-based fluorescence assay	[PMID: 20096591]
HEK293	EC₅₀	190 μM Compound: Glu	Agonist activity at rat recombinant GluR2(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay Agonist activity at rat recombinant GluR2(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	[PMID: 19588945]
HEK293	EC₅₀	2.88 μM Compound: 1, Glu	Agonist activity at rat mGlu4 receptor expressed in HEK293 cells coexpressing Gq/Gi and EAAC1 assessed as intracellular calcium production measured every 1.5 secs for 60 secs by Fluo-4-AM based fluorometry Agonist activity at rat mGlu4 receptor expressed in HEK293 cells coexpressing Gq/Gi and EAAC1 assessed as intracellular calcium production measured every 1.5 secs for 60 secs by Fluo-4-AM based fluorometry	[PMID: 22750138]
HEK293	EC₅₀	20 μM Compound: (S)-Glutamate	Agonist activity at rat recombinant GluA4 receptor flip isoform expressed in HEK293 cells assessed as effect on cyclothiazide-induced calcium flux by Fluo-4/AM staining-based fluorescence assay Agonist activity at rat recombinant GluA4 receptor flip isoform expressed in HEK293 cells assessed as effect on cyclothiazide-induced calcium flux by Fluo-4/AM staining-based fluorescence assay	[PMID: 20096591]
HEK293	EC₅₀	20 μM Compound: Glu	Agonist activity at rat recombinant GluR4 flip isomer expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay Agonist activity at rat recombinant GluR4 flip isomer expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	[PMID: 19588945]
HEK293	EC₅₀	21.47 μM Compound: Glutamate	Agonist activity at rat mGluR8 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay Agonist activity at rat mGluR8 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay	[PMID: 25958247]
HEK293	EC₅₀	22 μM Compound: 1,Glu	Induction of calcium influx in HEK293 cells expressing human GLUK5 by FLIPR assay Induction of calcium influx in HEK293 cells expressing human GLUK5 by FLIPR assay	[PMID: 16610801]
HEK293	EC₅₀	23.16 μM Compound: Glutamate	Agonist activity at rat mGluR1 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay Agonist activity at rat mGluR1 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay	[PMID: 25958247]
HEK293	EC₅₀	24 μM Compound: 1; (S)-Glu	Agonist activity at GluA3 receptor (unknown origin) expressed in HEK293 cells assessed induction of S-glutamate-induced calcium flux measured after 90 secs in presence of cyclothiazide by Fluo4-AM dye-based fluorescence assay Agonist activity at GluA3 receptor (unknown origin) expressed in HEK293 cells assessed induction of S-glutamate-induced calcium flux measured after 90 secs in presence of cyclothiazide by Fluo4-AM dye-based fluorescence assay	[PMID: 30943028]
HEK293	EC₅₀	25 μM Compound: Glutamate	Compound was tested for agonistic activity at Glutamate receptor 6 using HEK293 cells Compound was tested for agonistic activity at Glutamate receptor 6 using HEK293 cells	[PMID: 10969973]
HEK293	EC₅₀	27 μM Compound: 1,Glu	Induction of calcium influx in HEK293 cells expressing human GLUK5/GLUK6 by FLIPR assay Induction of calcium influx in HEK293 cells expressing human GLUK5/GLUK6 by FLIPR assay	[PMID: 16610801]
HEK293	EC₅₀	28 μM Compound: (S)-Glu	Agonist activity at GluR4 expressed in HEK293 cells by Fluo-4/Ca2+ assay Agonist activity at GluR4 expressed in HEK293 cells by Fluo-4/Ca2+ assay	[PMID: 17672447]
HEK293	EC₅₀	33 μM Compound: 1; (S)-Glu	Agonist activity at GluA1 receptor (unknown origin) expressed in HEK293 cells assessed induction of S-glutamate-induced calcium flux measured after 90 secs in presence of cyclothiazide by Fluo4-AM dye-based fluorescence assay Agonist activity at GluA1 receptor (unknown origin) expressed in HEK293 cells assessed induction of S-glutamate-induced calcium flux measured after 90 secs in presence of cyclothiazide by Fluo4-AM dye-based fluorescence assay	[PMID: 30943028]
HEK293	EC₅₀	35 μM Compound: 1,Glu	Induction of calcium influx in HEK293 cells expressing human GLUK5/GLUK2 by FLIPR assay Induction of calcium influx in HEK293 cells expressing human GLUK5/GLUK2 by FLIPR assay	[PMID: 16610801]
HEK293	EC₅₀	35 μM Compound: L-Glu	Activity at rat cloned iGluR1 expressed in human HEK293 cells by calcium imaging assay Activity at rat cloned iGluR1 expressed in human HEK293 cells by calcium imaging assay	[PMID: 18338843]
HEK293	EC₅₀	39 μM Compound: (S)-Glu	Agonist activity at GluR1 E683A mutant expressed in HEK293 cells by Fluo-4/Ca2+ assay Agonist activity at GluR1 E683A mutant expressed in HEK293 cells by Fluo-4/Ca2+ assay	[PMID: 17672447]
HEK293	EC₅₀	398 μM Compound: L-glu	Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells	[PMID: 35677430]
HEK293	EC₅₀	4.7 μM Compound: Glu	Agonist activity at rat mGlu5 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assay Agonist activity at rat mGlu5 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assay	[PMID: 26814576]
HEK293	EC₅₀	4.8 μM Compound: 1; (S)-Glu	Agonist activity at GluA4 receptor (unknown origin) expressed in HEK293 cells assessed induction of S-glutamate-induced calcium flux measured after 90 secs in presence of cyclothiazide by Fluo4-AM dye-based fluorescence assay Agonist activity at GluA4 receptor (unknown origin) expressed in HEK293 cells assessed induction of S-glutamate-induced calcium flux measured after 90 secs in presence of cyclothiazide by Fluo4-AM dye-based fluorescence assay	[PMID: 30943028]
HEK293	EC₅₀	51 μM Compound: (S)-Glutamate	Agonist activity at rat recombinant GluA1 receptor flip isoform expressed in HEK293 cells assessed as effect on cyclothiazide-induced calcium flux by Fluo-4/AM staining-based fluorescence assay Agonist activity at rat recombinant GluA1 receptor flip isoform expressed in HEK293 cells assessed as effect on cyclothiazide-induced calcium flux by Fluo-4/AM staining-based fluorescence assay	[PMID: 20096591]
HEK293	EC₅₀	51 μM Compound: Glu	Agonist activity at rat recombinant GluR1 flip isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay Agonist activity at rat recombinant GluR1 flip isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	[PMID: 19588945]
HEK293	EC₅₀	52 μM Compound: (S)-Glutamate	Agonist activity at rat recombinant GluA3 receptor flip isoform expressed in HEK293 cells assessed as effect on cyclothiazide-induced calcium flux by Fluo-4/AM staining-based fluorescence assay Agonist activity at rat recombinant GluA3 receptor flip isoform expressed in HEK293 cells assessed as effect on cyclothiazide-induced calcium flux by Fluo-4/AM staining-based fluorescence assay	[PMID: 20096591]
HEK293	EC₅₀	52 μM Compound: Glu	Agonist activity at rat recombinant GluR3 flip isomer expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay Agonist activity at rat recombinant GluR3 flip isomer expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	[PMID: 19588945]
HEK293	EC₅₀	57 μM Compound: 1; (S)-Glu	Agonist activity at GluA2(Q) receptor (unknown origin) expressed in HEK293 cells assessed induction of S-glutamate-induced calcium flux measured after 90 secs in presence of cyclothiazide by Fluo4-AM dye-based fluorescence assay Agonist activity at GluA2(Q) receptor (unknown origin) expressed in HEK293 cells assessed induction of S-glutamate-induced calcium flux measured after 90 secs in presence of cyclothiazide by Fluo4-AM dye-based fluorescence assay	[PMID: 30943028]
HEK293	EC₅₀	60 μM Compound: (S)-Glu	Agonist activity at GluR1 D399S/M686V/I687A mutant expressed in HEK293 cells by Fluo-4/Ca2+ assay Agonist activity at GluR1 D399S/M686V/I687A mutant expressed in HEK293 cells by Fluo-4/Ca2+ assay	[PMID: 17672447]
HEK293	EC₅₀	63 μM Compound: (S)-Glu	Agonist activity at GluR1 M686V mutant expressed in HEK293 cells by Fluo-4/Ca2+ assay Agonist activity at GluR1 M686V mutant expressed in HEK293 cells by Fluo-4/Ca2+ assay	[PMID: 17672447]
HEK293	EC₅₀	65.09 μM Compound: Glu	Agonist activity at rat mGlu6 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay Agonist activity at rat mGlu6 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay	[PMID: 26814576]
HEK293	EC₅₀	66 μM Compound: L-Glu	Activity at rat cloned iGluR6 expressed in human HEK293 cells by calcium imaging assay Activity at rat cloned iGluR6 expressed in human HEK293 cells by calcium imaging assay	[PMID: 18338843]
HEK293	EC₅₀	67 μM Compound: (S)-Glu	Agonist activity at GluR3 expressed in HEK293 cells by Fluo-4/Ca2+ assay Agonist activity at GluR3 expressed in HEK293 cells by Fluo-4/Ca2+ assay	[PMID: 17672447]
HEK293	EC₅₀	69 μM Compound: (S)-Glu	Agonist activity at GluR1 D399S mutant expressed in HEK293 cells by Fluo-4/Ca2+ assay Agonist activity at GluR1 D399S mutant expressed in HEK293 cells by Fluo-4/Ca2+ assay	[PMID: 17672447]
HEK293	EC₅₀	71 μM Compound: (S)-Glu	Agonist activity at GluR1 expressed in HEK293 cells by Fluo-4/Ca2+ assay Agonist activity at GluR1 expressed in HEK293 cells by Fluo-4/Ca2+ assay	[PMID: 17672447]
HEK293	EC₅₀	73 μM Compound: Glu	Agonist activity at rat recombinant GluR6(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay Agonist activity at rat recombinant GluR6(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	[PMID: 19588945]
HEK293	EC₅₀	75 μM Compound: Glutamate	Compound was tested for agonistic activity at Glutamate receptor 5 using HEK293 cells Compound was tested for agonistic activity at Glutamate receptor 5 using HEK293 cells	[PMID: 10969973]
HEK293	EC₅₀	76 μM Compound: (S)-Glu	Agonist activity at GluR1 M686V/I687 mutant expressed in HEK293 cells by Fluo-4/Ca2+ assay Agonist activity at GluR1 M686V/I687 mutant expressed in HEK293 cells by Fluo-4/Ca2+ assay	[PMID: 17672447]
HEK293	EC₅₀	8.99 μM Compound: Glu	Agonist activity at rat mGlu5 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay Agonist activity at rat mGlu5 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay	[PMID: 26814576]
HEK293	EC₅₀	82.21 μM Compound: Glutamate	Agonist activity at rat mGluR6 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay Agonist activity at rat mGluR6 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay	[PMID: 25958247]
HEK293	EC₅₀	9.49 μM Compound: Glu	Agonist activity at rat mGlu4 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay Agonist activity at rat mGlu4 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay	[PMID: 26814576]
Oocyte	EC₅₀	0.45 μM Compound: 1, Glu	Activity at rat NR1/NR2D receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology Activity at rat NR1/NR2D receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology	[PMID: 18578474]
Oocyte	EC₅₀	1 μM Compound: 1, Glu	Activity at rat recombinant NR1/NR2C receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology Activity at rat recombinant NR1/NR2C receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology	[PMID: 18578474]
Oocyte	EC₅₀	1.8 μM Compound: 1, Glu	Activity at rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology Activity at rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology	[PMID: 18578474]
Oocyte	EC₅₀	108 μM Compound: (S)-Glu	Agonist activity at rat GluK2 mutant expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiology Agonist activity at rat GluK2 mutant expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiology	[PMID: 21619066]
Oocyte	EC₅₀	14 μM Compound: (S)-Glu	Activity at recombinant iGluR2 receptor expressed in Xenopus laevis oocytes using holding potential of -15 to -20 mV by TEVC electrophysiology Activity at recombinant iGluR2 receptor expressed in Xenopus laevis oocytes using holding potential of -15 to -20 mV by TEVC electrophysiology	[PMID: 20408529]
Oocyte	EC₅₀	2.9 μM Compound: 1, Glu	Activity at rat recombinant NR1/NR2A receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology Activity at rat recombinant NR1/NR2A receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology	[PMID: 18578474]
Oocyte	EC₅₀	83.5 μM Compound: (S)-Glu	Agonist activity at Non-desensitized homomeric rat GluK1(Q)1b mutant expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiology Agonist activity at Non-desensitized homomeric rat GluK1(Q)1b mutant expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiology	[PMID: 21619066]
Oocyte	EC₅₀	9030 μM Compound: (S)-Glu	Agonist activity at non-desensitized homomeric rat GluK3 mutant expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiology Agonist activity at non-desensitized homomeric rat GluK3 mutant expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiology	[PMID: 21619066]

体外研究
(In Vitro)

L-Glutamic acid (120, 500, 750, 1000 mg/dL) 可降低锂对非洲爪蟾胚胎发育的有害影响^[3]。
L-Glutamic acid (2, 5, 10, 20 mM, 24-48 h) 在神经母细胞瘤中可诱导神经兴奋毒性^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:	SH-SY5Y, IMR-32, SK-N-BE(2)
Concentration:	2, 5, 10, 20 mM
Incubation Time:	24 and 48 h
Result:	Reduced cell viability in a dose-dependent manner.

体内研究
(In Vivo)

L-Glutamic acid (3 g/kg, 皮下注射) 在小鼠中可促进视网膜神经节细胞的兴奋毒性变性^[1]。
L-Glutamic acid (750 mg/kg, 腹腔注射) 在大鼠中可以减轻和抑制有机磷杀虫剂毒死蜱 (CPF) 诱导的氧化应激反应^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Crv4 mice model^[1]
Dosage:	3 g/kg
Administration:	s.c., single dose
Result:	Reduced the number of Brn-3a⁺ RGCs by >70%. In the absence of mGlu1 receptor, MSG-induced retinal damage is diminished.

Animal Model:	CPF-induced rat model^[5]
Dosage:	750 mg/kg
Administration:	i.p.
Result:	Reduced CPF-induced oxidative stress by increasing the level of GSH and activity of GSH-related enzymes.

分子量

147.13

Formula

C₅H₉NO₄

CAS 号

56-86-0

性状

固体

颜色

White to off-white

中文名称

L-谷氨酸

结构分类

Amino acids

初始来源

微生物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

H₂O 中的溶解度 : 6.25 mg/mL (42.48 mM; 超声助溶)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.7967 mL	33.9836 mL	67.9671 mL
5 mM	1.3593 mL	6.7967 mL	13.5934 mL
10 mM	0.6797 mL	3.3984 mL	6.7967 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： PBS
Solubility: 9.09 mg/mL (61.78 mM); 澄清溶液; 超声助溶 (<60°C)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.93%

选择批次：

Data Sheet (636 KB) SDS (393 KB)

COA (288 KB) HNMR (241 KB) RP-HPLC (238 KB) MS (68 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Liberatore F, et al. Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017 Nov 5;363:142-149. [Content Brief]

[2]. Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6(1):73-7. [Content Brief]

[3]. Boga Pekmezekmek A, et al. L-Glutamic acid monosodium salt reduces the harmful effect of lithium on the development of Xenopus laevis embryos. Environ Sci Pollut Res Int. 2020 Nov;27(33):42124-42132. [Content Brief]

[4]. Croce N, et al. Hydrochloric acid alters the effect of L-glutamic acid on cell viability in human neuroblastoma cell cultures. J Neurosci Methods. 2013 Jul 15;217(1-2):26-30. [Content Brief]

[5]. Salyha N, et al. Protective role of l-glutamic acid and l-cysteine in mitigation the chlorpyrifos-induced oxidative stress in rats. Environ Toxicol Pharmacol. 2018 Dec;64:155-163. [Content Brief]

L-Glutamic acid 相关分类

Neurological Disease

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.7967 mL	33.9836 mL	67.9671 mL	169.9178 mL
	5 mM	1.3593 mL	6.7967 mL	13.5934 mL	33.9836 mL
	10 mM	0.6797 mL	3.3984 mL	6.7967 mL	16.9918 mL
	15 mM	0.4531 mL	2.2656 mL	4.5311 mL	11.3279 mL
	20 mM	0.3398 mL	1.6992 mL	3.3984 mL	8.4959 mL
	25 mM	0.2719 mL	1.3593 mL	2.7187 mL	6.7967 mL
	30 mM	0.2266 mL	1.1328 mL	2.2656 mL	5.6639 mL
	40 mM	0.1699 mL	0.8496 mL	1.6992 mL	4.2479 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Glutamic acid56-86-0L-谷氨酸Endogenous MetaboliteiGluRFerroptosisApoptosisIonotropic glutamate receptorsNMDAAgonistSH-SY5YIMR-32SK-N-BE(2)NeurotoxicityCrv4 miceInhibitorinhibitorinhibit

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L-Glutamic acid (Synonyms: L-谷氨酸)

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MCE 顾客使用本产品发表的 7 篇科研文献

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L-Glutamic acid (Synonyms: L-谷氨酸)

Customer Review

Other Forms of L-Glutamic acid:

L-Glutamic acid 相关抗体

MCE 顾客使用本产品发表的 7 篇科研文献

L-Glutamic acid 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

查看 iGluR 亚型特异性产品:

生物活性

纯度 & 产品资料

参考文献

L-Glutamic acid 相关抗体:

摩尔计算器

稀释计算器

L-Glutamic acid 相关分类

完整储备液配制表

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您最近查看的产品:

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