2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. DACA

DACA 在体外抑制两种必需的核酶，DNA 拓扑异构酶 I (topo I) 和 DNA拓扑异构酶 II (topo II) 。DACA 稳定人白血病 CCRF-CEM 细胞中的 topo I, topo II α 和 topo II β 可切割复合物。

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DACA Chemical Structure

DACA Chemical Structure

CAS No. : 89459-25-6

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥770
In-stock
5 mg ￥700
In-stock
10 mg ￥1100
In-stock
25 mg ￥2200
In-stock
50 mg ￥3400
In-stock
100 mg ￥5400
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of DACA:

DACA 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DLD-1 IC50
2.3 μM
Compound: 4, DACA, NSC-601316
Cytotoxicity against human DLD1 cells by Hoechst test
Cytotoxicity against human DLD1 cells by Hoechst test
[PMID: 18656367]
DLD-1 IC50
3.1 μM
Compound: 4, DACA, NSC-601316
Cytotoxicity against human DLD1 cells by resazurin reduction test
Cytotoxicity against human DLD1 cells by resazurin reduction test
[PMID: 18656367]
DU-145 IC50
2 μM
Compound: 8b; DACA
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by Sulforhodamine B staining method
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by Sulforhodamine B staining method
[PMID: 33077264]
Fibroblast IC50
4.4 μM
Compound: 4, DACA, NSC-601316
Cytotoxicity against human fibroblast cells by resazurin reduction test
Cytotoxicity against human fibroblast cells by resazurin reduction test
[PMID: 18656367]
Fibroblast IC50
7.1 μM
Compound: 4, DACA, NSC-601316
Cytotoxicity against human fibroblast cells by Hoechst test
Cytotoxicity against human fibroblast cells by Hoechst test
[PMID: 18656367]
HT-29 IC50
990 nM
Compound: 3a
Cytotoxicity against human HT-29 cells after 144 hrs
Cytotoxicity against human HT-29 cells after 144 hrs
[PMID: 18774722]
Jurkat IC50
0.3 μM
Compound: 4, DACA, NSC-601316
Cytotoxicity against human Jurkat cells by Hoechst test
Cytotoxicity against human Jurkat cells by Hoechst test
[PMID: 18656367]
Jurkat IC50
0.56 μM
Compound: 4, DACA, NSC-601316
Cytotoxicity against human Jurkat cells by resazurin reduction test
Cytotoxicity against human Jurkat cells by resazurin reduction test
[PMID: 18656367]
L1210 IC50
105 nM
Compound: 2
Compound concentration that reduces cell growth of L1210 leukemia cultures to 50% of controls after 70h.
Compound concentration that reduces cell growth of L1210 leukemia cultures to 50% of controls after 70h.
[PMID: 3361574]
L1210 IC50
98 nM
Compound: 3
Inhibition of L1210 cell growth by 50%
Inhibition of L1210 cell growth by 50%
[PMID: 11831901]
M4Beu cell line IC50
1.8 μM
Compound: 4, DACA, NSC-601316
Cytotoxicity against human M4Beu cells by Hoechst test
Cytotoxicity against human M4Beu cells by Hoechst test
[PMID: 18656367]
M4Beu cell line IC50
4.5 μM
Compound: 4, DACA, NSC-601316
Cytotoxicity against human M4Beu cells by resazurin reduction test
Cytotoxicity against human M4Beu cells by resazurin reduction test
[PMID: 18656367]
PC-3 IC50
1.86 μM
Compound: 8b; DACA
Antiproliferative activity against human PC-3 cells incubated for 48 hrs by Sulforhodamine B staining method
Antiproliferative activity against human PC-3 cells incubated for 48 hrs by Sulforhodamine B staining method
[PMID: 33077264]
分子量

293.36

Formula

C18H19N3O
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (340.88 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.4088 mL 17.0439 mL 34.0878 mL
5 mM 0.6818 mL 3.4088 mL 6.8176 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

DACA 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4088 mL 17.0439 mL 34.0878 mL 85.2195 mL
5 mM 0.6818 mL 3.4088 mL 6.8176 mL 17.0439 mL
10 mM 0.3409 mL 1.7044 mL 3.4088 mL 8.5220 mL
15 mM 0.2273 mL 1.1363 mL 2.2725 mL 5.6813 mL
20 mM 0.1704 mL 0.8522 mL 1.7044 mL 4.2610 mL
25 mM 0.1364 mL 0.6818 mL 1.3635 mL 3.4088 mL
30 mM 0.1136 mL 0.5681 mL 1.1363 mL 2.8407 mL
40 mM 0.0852 mL 0.4261 mL 0.8522 mL 2.1305 mL
50 mM 0.0682 mL 0.3409 mL 0.6818 mL 1.7044 mL
60 mM 0.0568 mL 0.2841 mL 0.5681 mL 1.4203 mL
80 mM 0.0426 mL 0.2130 mL 0.4261 mL 1.0652 mL
100 mM 0.0341 mL 0.1704 mL 0.3409 mL 0.8522 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DACA89459-25-6Topoisomerasehuman leukaemia CCRF-CEM cellsDNA topoisomerase I and II cleavable complexesInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-100777
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