2. Gene
  3. PDCD10 - programmed cell death 10 Gene

PDCD10 - programmed cell death 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：程序性细胞死亡 10

种属: Homo sapiens

同用名: CCM3; TFAR15

基因 ID: 11235 | 基因类型: protein coding

关于 PDCD10

Cytogenetic location: 3q26.1 Genomic coordinates (GRCh38): 3:167,683,298-167,734,892 (from NCBI)

This gene has 18 transcripts (splice variants), 279 orthologues and is associated with 3 phenotypes. Ubiquitous expression in colon (RPKM 13.1), lymph node (RPKM 11.6) and 25 other tissues.

功能概要

该基因编码一种与细胞凋亡相关的进化保守蛋白。该蛋白与丝氨酸/苏氨酸蛋白激酶 MST4 相互作用，以调节细胞外信号调节激酶 (ERK) 通路。它还与丝氨酸/苏氨酸激酶 25 相互作用并被其磷酸化，并且被认为在血管发育所必需的信号通路中发挥作用。该基因的突变是脑海绵状血管畸形的原因之一，脑海绵状血管畸形是导致癫痫发作和脑出血的血管畸形。已经鉴定出编码相同蛋白质的多个可变剪接变体。[RefSeq 提供，2008 年 7 月]

This gene encodes an evolutionarily conserved protein associated with cell Apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

PDCD10 基因产物(3)

mRNA Protein Name
NM_007217.4 NP_009148.2 programmed cell death protein 10
NM_145859.2 NP_665858.1 programmed cell death protein 10
NM_145860.2 NP_665859.1 programmed cell death protein 10
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
20489202 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Golgi reassembly IMP
IMP: 通过突变表型推断
20332113 GOA
involved in establishment of Golgi localization IMP
IMP: 通过突变表型推断
20332113 GOA
involved in intracellular signal transduction IMP
IMP: 通过突变表型推断
22291017 GOA
involved in intrinsic apoptotic signaling pathway in response to hydrogen peroxide IGI
IGI: 通过遗传相互作用推断
22652780 GOA
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
17360971 GOA
involved in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
23388056 GOA
involved in negative regulation of cell migration involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
23388056 GOA
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
23388056 GOA
involved in positive regulation of MAP kinase activity IDA
IDA: 通过直接分析推断
17360971 GOA
involved in positive regulation of Notch signaling pathway IMP
IMP: 通过突变表型推断
23388056 GOA
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
23541896 GOA
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
20332113 GOA
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
17360971 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
23388056 GOA
involved in positive regulation of intracellular protein transport IMP
IMP: 通过突变表型推断
27807006 GOA
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
20332113 GOA
involved in positive regulation of protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
20332113 GOA
involved in positive regulation of stress-activated MAPK cascade IDA
IDA: 通过直接分析推断
22652780 GOA
involved in protein stabilization IMP
IMP: 通过突变表型推断
20332113 GOA
NOT involved in regulation of Rho protein signal transduction IMP
IMP: 通过突变表型推断
20332113 GOA
NOT involved in stress fiber assembly IMP
IMP: 通过突变表型推断
20332113 GOA
involved in wound healing, spreading of cells IMP
IMP: 通过突变表型推断
20332113 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of FAR/SIN/STRIPAK complex IDA
IDA: 通过直接分析推断
18782753 GOA
colocalizes with Golgi apparatus IDA
IDA: 通过直接分析推断
22652780 GOA
located in Golgi apparatus IDA
IDA: 通过直接分析推断
20332113 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
22652780 GOA
located in cytosol IDA
IDA: 通过直接分析推断
17360971 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDCD10 蛋白结构

DUF1241

DUF1241: Protein of unknown function (DUF1241) (11 - 162)

  • 0
  • 100
  • 200
  • 212 a.a.
蛋白主名 其他名称

programmed cell death protein 10

TF-1 cell apoptosis-related protein 15

PDCD10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PDCD10 Q9BUL8 C4orf19 Homo sapiens Q8IY42
Y2H Array
32296183
种属内
PDCD10 Q9BUL8 C4orf19 Homo sapiens Q8IY42
Y2H Array
31515488
种属内
PDCD10 Q9BUL8 C4orf19 Homo sapiens Q8IY42
Y2H Prey Pooling
25416956
种属内
PDCD10 Q9BUL8 C4orf19 Homo sapiens Q8IY42
Y2H Prey Pooling
32296183
种属内
PDCD10 Q9BUL8 q96ba2_human Homo sapiens Q96BA2
Y2H Prey Pooling
25416956
种属内
PDCD10 Q9BUL8 q96ba2_human Homo sapiens Q96BA2
Validated Y2H
25416956
种属内
PDCD10 Q9BUL8 STK24 Homo sapiens Q9Y6E0-2
Validated Y2H
32296183
种属内
PDCD10 Q9BUL8 STK24 Homo sapiens Q9Y6E0-2
Y2H Array
25416956
种属内
PDCD10 Q9BUL8 STK24 Homo sapiens Q9Y6E0-2
Y2H Array
32296183
种属内
PDCD10 Q9BUL8 STK24 Homo sapiens Q9Y6E0-2
Y2H Prey Pooling
25416956
种属内
PDCD10 Q9BUL8 STK24 Homo sapiens Q9Y6E0-2
Y2H Prey Pooling
32296183
种属内
PDCD10 Q9BUL8 STK24 Homo sapiens Q9Y6E0-2
Anti Tag CoIP
28514442
种属内
PDCD10 Q9BUL8 STRN Homo sapiens O43815
Anti Tag CoIP
18782753
种属内
PDCD10 Q9BUL8 STRN Homo sapiens O43815
Anti Tag CoIP
28514442
种属内
PDCD10 Q9BUL8 MINAR1 Homo sapiens Q9UPX6
Validated Y2H
32296183
种属内
PDCD10 Q9BUL8 MINAR1 Homo sapiens Q9UPX6
Y2H Array
32296183
种属内
PDCD10 Q9BUL8 MINAR1 Homo sapiens Q9UPX6
Y2H Prey Pooling
32296183
种属内
PDCD10 Q9BUL8 FRYL Homo sapiens O94915-2
Y2H Array
32296183
种属内
PDCD10 Q9BUL8 FRYL Homo sapiens O94915-2
Y2H Prey Pooling
32296183
种属内
PDCD10 Q9BUL8 STRN Homo sapiens O43815-2
Y2H Prey Pooling
32296183
种属内
PDCD10 Q9BUL8 STRN Homo sapiens O43815-2
Y2H Array
32296183
种属内
PDCD10 Q9BUL8 PROSER2 Homo sapiens Q86WR7-2
Y2H Array
32296183
种属内
PDCD10 Q9BUL8 PROSER2 Homo sapiens Q86WR7-2
Y2H Prey Pooling
32296183
种属内
PDCD10 Q9BUL8 CCM2 Homo sapiens Q9BSQ5
Anti Tag CoIP
17657516
种属内
PDCD10 Q9BUL8 CCM2 Homo sapiens Q9BSQ5
Confocal
17657516
种属内
PDCD10 Q9BUL8 CCM2 Homo sapiens Q9BSQ5
Pull Down
17657516
种属内
PDCD10 Q9BUL8 STK26 Homo sapiens Q9P289-1
BLI
23541896
种属内
PDCD10 Q9BUL8 STK26 Homo sapiens Q9P289-1
Pull Down
23541896
种属内
PDCD10 Q9BUL8 STK26 Homo sapiens Q9P289-1
GMS
23541896
种属内
PDCD10 Q9BUL8 STK26 Homo sapiens Q9P289-1
X-Ray Diffraction
23665169
种属内
PDCD10 Q9BUL8 STK26 Homo sapiens Q9P289-1
X-Ray Diffraction
23541896
种属内
PDCD10 Q9BUL8 STK26 Homo sapiens Q9P289-1
SPR
23665169
种属内
PDCD10 Q9BUL8 STK26 Homo sapiens Q9P289-1
Anti Tag CoIP
23541896
种属内
PDCD10 Q9BUL8 PLEKHS1 Homo sapiens Q5SXH7-1
Y2H Array
32296183
种属内
PDCD10 Q9BUL8 PLEKHS1 Homo sapiens Q5SXH7-1
Y2H Prey Pooling
32296183
种属内
PDCD10 Q9BUL8 PTPN13 Homo sapiens Q12923
Pull Down
17657516
种属内
PDCD10 Q9BUL8 PTPN13 Homo sapiens Q12923
Anti Tag CoIP
17657516
种属内
PDCD10 Q9BUL8 MST4 Homo sapiens Q499L9
Y2H Array
25416956
种属内
PDCD10 Q9BUL8 MST4 Homo sapiens Q499L9
Y2H Prey Pooling
25416956
种属内
PDCD10 Q9BUL8 STK26 Homo sapiens Q9P289
Anti Tag CoIP
33961781
种属内
PDCD10 Q9BUL8 STK26 Homo sapiens Q9P289
Y2H Prey Pooling
32296183
种属内
PDCD10 Q9BUL8 STK26 Homo sapiens Q9P289
Validated Y2H
32296183
种属内
PDCD10 Q9BUL8 STK26 Homo sapiens Q9P289
Anti Tag CoIP
18782753
种属内
PDCD10 Q9BUL8 STK26 Homo sapiens Q9P289
Y2H Array
32296183
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
Y2H
17657516
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
Y2H
21516116
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
Pull Down
17657516
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
Y2H Prey Pooling
25416956
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
SPR
23665169
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
Solution Sedimentation
23665169
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
Anti Tag CoIP
17657516
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
Anti Tag CoIP
18782753
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
Y2H Prey Pooling
32296183
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
X-Ray Diffraction
23665169
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
Pull Down
23665169
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
Anti Tag CoIP
28514442
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
GMS
23665169
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
Y2H Array
25416956
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
Anti Tag CoIP
33961781
种属内
PDCD10 Q9BUL8 STK25 Homo sapiens O00506
Y2H Array
32296183
种属内
PDCD10 Q9BUL8 FARSA Homo sapiens Q9Y285
Validated Y2H
32296183
种属内
PDCD10 Q9BUL8 STK24 Homo sapiens Q9Y6E0
BLI
23541896
种属内
PDCD10 Q9BUL8 STK24 Homo sapiens Q9Y6E0
Anti Tag CoIP
18782753
种属内
PDCD10 Q9BUL8 STK24 Homo sapiens Q9Y6E0
Pull Down
23541896
种属内
PDCD10 Q9BUL8 STK24 Homo sapiens Q9Y6E0
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PDCD10 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71190 PDCD10 Protein, Human Q9BUL8 (M1-Al212 ) ≥95%

关联疾病

疾病名称 别名
Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3

CCM3

Cerebral Cavernous Malformations-3

Cavernous Angiomatous Malformations

Cavernous Hemangioma Of The Brain

Cerebral Capillary Malformations

Cerebral Cavernoma

Familial Cavernous Angioma

Cerebral Cavernous Malformations, Type 3
Cerebral Cavernous Malformations

Cerebral Cavernous Malformation

Cavernous Malformations Of Cns And Retina

Cerebral Cavernous Malformation 1

Cavernous Angiomatous Malformations

Cerebral Capillary Malformations

CCM

Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

Familial Cavernous Angioma

Cavernous Angioma

Familial Cerebral Cavernous Malformation

Cerebral Cavernous Malformations 1

Cavernous Angioma, Familial

Cam

Cerebral Cavernous Malformations-1

Cavernoma

Central Nervous System Cavernous Hemangioma

Cerebral Cavernous Hemangioma

Familial Cavernous Hemangioma

Familial Cavernous Malformation

Familial Cerebral Cavernous Angioma

Intracerebral Cavernous Hemangioma

CCM1

Cavernous Hemangioma Of The Brain

Cerebral Cavernoma

Cerebral Cavernous Malformations, Type 1

Hemangioma, Cavernous, Central Nervous System

Hemangioma, Cavernous

Angioma, Cavernous
Cerebral Cavernous Malformation, Familial

Familial Cerebral Cavernous Malformation

Familial Cavernous Hemangioma

Familial Cerebral Cavernous Angioma

Familial Brain Cavernous Angioma

Familial Cerebral Cavernoma

Hereditary Brain Cavernous Angioma

Hereditary Cerebral Cavernoma

Hereditary Cerebral Cavernous Malformation
Cavernous Hemangioma

Hemangioma, Cavernous

Cavernoma

Cavernous Haemangioma
Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation

Intracranial Arteriovenous Malformation

Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To

Intracranial Arteriovenous Malformations

Bavm

Cerebral Arteriovenous Malformations

Intracranial Hemorrhage In Brain Cerebrovascular Malformations

Arteriovenous Malformation Of The Brain, Somatic

Intracranial Avm

Arteriovenous Malformations Cerebral
Klippel-Trenaunay-Weber Syndrome

Klippel-Trenaunay Syndrome

KTS

Ktw Syndrome

Angioosteohypertrophy Syndrome

Angio-Osteohypertrophy Syndrome

Klippel Trenaunay Syndrome

Klippel-Trénaunay-Weber Syndrome

Haemangiectatic Hypertrophy

Weber-Klippel-Trenaunay

Congenital Dysplastic Angiopathy

Klippel-Trenaunay Disease

Weber Klippel Trenaunay
Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome

CCMS

Rib Gap Defects With Micrognathia

Ccm Syndrome
Cerebral Cavernous Malformations 2

Cerebral Cavernous Malformation 2

CCM2

Cerebral Cavernous Malformations-2

Cavernous Angiomatous Malformations

Cavernous Hemangioma Of The Brain

Cerebral Capillary Malformations

Cerebral Cavernoma

Familial Cavernous Angioma

Cerebral Cavernous Malformations, Type 2
Brain Angioma

Brain Hemangioma
Intracranial Cavernous Angioma

Intracranial Cavernoma

Intracranial Cavernous Hemangioma
Intracranial Structure Hemangioma

Angioma Of Intracranial Structure

Hemangioma Of Intracranial Structure

Hemangioma Of Intracranial Structures
Cerebral Angioma

Hemangioma Of Cerebrum

Cerebral Hemangioma
Venous Malformations, Multiple Cutaneous And Mucosal

VMCM

Multiple Cutaneous And Mucosal Venous Malformations

Mucocutaneous Venous Malformations

Vmcm1

Cutaneous And Mucosal Venous Malformation

Dominantly Inherited Venous Malformations
Vascular Disease

Vascular Diseases

Aneurysm

Spinal Cord Ischemia

Vascular Anomaly

Spinal Cord Vascular Diseases

Vascular Tissue Disease
Hemangioma Of Liver

Hepatic Hemangioma

Angioma Of Liver

Hepatic Angioma
Myopathy, Centronuclear, 4

CNM4

Centronuclear Myopathy 4

Congenital Myopathy With Internal Nuclei And Atypical Cores

Centronuclear Myopathy Type 4

Myopathy, Centronuclear, Type 4
Intracranial Abscess

Abscess Of Brain

Brain Empyema

Cranial Abscess

Intracerebral Abscess

Cerebral Abscess

Cerebral Embolic Abscess

Cerebral Pyogenic Abscess

Septic Brain Infection

Temporosphenoidal Abscess

Ventricular Empyema

Intracranial Suppuration

Intracranial Vein Sinus Abscess
3-Methylcrotonyl-Coa Carboxylase 2 Deficiency

MCC2D

Mcc2 Deficiency

3-Methylcrotonyl Coa Carboxylase 2 Deficiency

3-Methylcrotonylglycinuria Ii

Methylcrotonylglycinuria, Type Ii

3-Methylcrotonoyl-Coa Carboxylase 2 Deficiency

3-Methylcrotonylglycinuria Type Ii

Mcgii

Methylcrotonylglycinuria Type Ii
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Hemorrhagic Disease

Hemorrhagic Disorders

Hemorrhagic Diathesis

Hemorrhagic Diseases

Bleeding Tendency

Acquired Coagulation Factor Inhibitor Disorder

Acquired Inhibitor Of Coagulation

Antithrombinaemia

Antithromboplastinogenaemia

Circulating Anticoagulant Disorder

Haemorrhagic Disorder Due To Antithrombinaemia

Haemorrhagic Disorder Due To Excess Administered Heparin

Antithromboplastinaemia

Haemorrhagic Disorder Due To Hyperheparinemia
Arteriovenous Malformation

Arteriovenous Malformations

Arteriovenous Hemangioma

Cirsoid Aneurysm

Racemose Aneurysm

Racemose Angioma

Racemose Hemangioma

Congenital Arteriovenous Malformation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10188 PDCD10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PDCD10 RGD RGD:1359329
Felis catus PDCD10 VGNC VGNC:68743
Bos taurus PDCD10 VGNC VGNC:32658
Mus musculus PDCD10 MGD MGI:1928396
Macaca mulatta PDCD10 VGNC VGNC:75793
Canis familiaris PDCD10 VGNC VGNC:53465
Others PDCD10 NCBI
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