2. Gene
  3. Cry2 - cryptochrome 2 (photolyase-like) Gene

Cry2 - cryptochrome 2 (photolyase-like) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: D130054K12Rik

基因 ID: 12953 | 基因类型: protein coding

关于 Cry2

功能概要

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across Plants and Animals. [provided by RefSeq, Feb 2014]

Cry2 基因产物(1)

mRNA Protein Name
NM_009963.4 NP_034093.1 cryptochrome-2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables FAD binding IDA
IDA: 通过直接分析推断
23503662 MGI
enables kinase binding IPI
IPI: 通过物理相互作用推断
24158435 MGI
enables nuclear receptor binding IPI
IPI: 通过物理相互作用推断
22170608 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14701732 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
20123978 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
21680841 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in circadian regulation of gene expression IGI
IGI: 通过遗传相互作用推断
22170608 MGI
involved in circadian regulation of gene expression IMP
IMP: 通过突变表型推断
19299583 MGI
acts upstream of or within circadian rhythm IMP
IMP: 通过突变表型推断
12024206 MGI
involved in circadian rhythm IMP
IMP: 通过突变表型推断
20123978 MGI
involved in entrainment of circadian clock by photoperiod IMP
IMP: 通过突变表型推断
23616524 MGI
involved in glucose homeostasis IGI
IGI: 通过遗传相互作用推断
22170608 MGI
involved in lipid storage IGI
IGI: 通过遗传相互作用推断
23531614 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12738229 MGI
involved in negative regulation of DNA-templated transcription IGI
IGI: 通过遗传相互作用推断
22170608 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
28683290 MGI
involved in negative regulation of circadian rhythm IDA
IDA: 通过直接分析推断
19605937 MGI
involved in negative regulation of glucocorticoid receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
22170608 MGI
involved in negative regulation of glucocorticoid secretion IGI
IGI: 通过遗传相互作用推断
23531614 MGI
acts upstream of or within protein import into nucleus IPI
IPI: 通过物理相互作用推断
15689618 MGI
involved in regulation of circadian rhythm IMP
IMP: 通过突变表型推断
10217146 MGI
involved in response to activity IMP
IMP: 通过突变表型推断
28683290 MGI
involved in response to insulin IGI
IGI: 通过遗传相互作用推断
23531614 MGI
involved in response to light stimulus IMP
IMP: 通过突变表型推断
29561690 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cry-Per complex IPI
IPI: 通过物理相互作用推断
20840750 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
9801304 MGI
located in nucleus IDA
IDA: 通过直接分析推断
9801304 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cryptochrome-2

Cry2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra Cry2 Q9R194 Fbxl3 Mus musculus Q8C4V4
Anti Tag CoIP
23452855
Intra Cry2 Q9R194 Fbxl3 Mus musculus Q8C4V4
Anti Tag CoIP
17462724
Intra Cry2 Q9R194 Per1 Mus musculus O35973
Y2H
24737000
Intra Cry2 Q9R194 Per2 Mus musculus O54943
Anti Bait CoIP
22170608
Intra Cry2 Q9R194 Per2 Mus musculus O54943
Y2H
20840750
Intra Cry2 Q9R194 Nr3c1 Mus musculus P06537-1
Anti Bait CoIP
22170608
Cross Cry2 Q9R194 FBXL3 Homo sapiens Q9UKT7
GMS
23503662
Cross Cry2 Q9R194 FBXL3 Homo sapiens Q9UKT7
Ion Exchange Chrom
23503662
Cross Cry2 Q9R194 FBXL3 Homo sapiens Q9UKT7
X-Ray Diffraction
23503662
Cross Cry2 Q9R194 FBXL3 Homo sapiens Q9UKT7
Anti Tag CoIP
23503662
Cross Cry2 Q9R194 FBXL3 Homo sapiens Q9UKT7
Pull Down
23503662
Cross Cry2 Q9R194 FBXL3 Homo sapiens Q9UKT7
SLCA
23503662
Cross Cry2 Q9R194 PER1 Homo sapiens O15534
Anti Tag CoIP
23503662
Intra Cry2 Q9R194 Bmal1 Mus musculus Q9WTL8
Y2H
24737000
Intra Cry2 Q9R194 Fbxl21 Mus musculus Q8BFZ4
Anti Tag CoIP
23452856
Intra Cry2 Q9R194 Fbxl21 Mus musculus Q8BFZ4
Anti Tag CoIP
23452855
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0318 Metronidazole 99.92% 是
HY-B0318A Metronidazole hydrochloride / 否
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108468 KL001 99.68% 否
HY-115672 KS15 99.40% 否
HY-134194 KL201 98.15% 否
HY-RS03205 CRY2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cry2 NCBI NCBI:1408
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