2. Gene
  3. Csf1 - colony stimulating factor 1 (macrophage) Gene

Csf1 - colony stimulating factor 1 (macrophage) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: op; Csfm; MCSF; BAP025; Mhdabap25

基因 ID: 12977 | 基因类型: protein coding

关于 Csf1

功能概要

Enables macrophage colony-stimulating factor receptor binding activity and protein homodimerization activity. Involved in several processes, including macrophage colony-stimulating factor signaling pathway; microglial cell proliferation; and positive regulation of gene expression. Acts upstream of or within several processes, including mammary gland development; osteoclast proliferation; and positive regulation of myeloid leukocyte differentiation. Located in extracellular space. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and hindlimb long bone. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Csf1 基因产物(3)

mRNA Protein Name
NM_001113529.1 NP_001107001.1 macrophage colony-stimulating factor 1 isoform 2 precursor
NM_001113530.1 NP_001107002.1 macrophage colony-stimulating factor 1 isoform 1 precursor
NM_007778.4 NP_031804.3 macrophage colony-stimulating factor 1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
22902366 MGI
enables macrophage colony-stimulating factor receptor binding IPI
IPI: 通过物理相互作用推断
2408759 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16267818 MGI
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
19017797 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of Ras protein signal transduction IDA
IDA: 通过直接分析推断
17053831 MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: 通过突变表型推断
10804170 MGI
involved in developmental process involved in reproduction IMP
IMP: 通过突变表型推断
16237150 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: 通过突变表型推断
9215625 MGI
involved in macrophage colony-stimulating factor signaling pathway IDA
IDA: 通过直接分析推断
19017797 MGI
acts upstream of macrophage differentiation IMP
IMP: 通过突变表型推断
9215625 MGI
acts upstream of or within macrophage homeostasis IMP
IMP: 通过突变表型推断
9215625 MGI
acts upstream of or within mammary duct terminal end bud growth IMP
IMP: 通过突变表型推断
10804170 MGI
acts upstream of or within mammary gland fat development IMP
IMP: 通过突变表型推断
10804170 MGI
involved in microglial cell proliferation IGI
IGI: 通过遗传相互作用推断
23392676 MGI
acts upstream of monocyte differentiation IMP
IMP: 通过突变表型推断
9215625 MGI
acts upstream of or within monocyte homeostasis IMP
IMP: 通过突变表型推断
9215625 MGI
acts upstream of myeloid leukocyte migration IGI
IGI: 通过遗传相互作用推断
17053831 MGI
acts upstream of or within neutrophil homeostasis IMP
IMP: 通过突变表型推断
9215625 MGI
acts upstream of or within osteoclast differentiation IDA
IDA: 通过直接分析推断
17442941 MGI
acts upstream of osteoclast differentiation IGI
IGI: 通过遗传相互作用推断
17053831 MGI
acts upstream of osteoclast differentiation IMP
IMP: 通过突变表型推断
9215625 MGI
acts upstream of or within osteoclast proliferation IDA
IDA: 通过直接分析推断
22451653 MGI
acts upstream of or within positive regulation of Ras protein signal transduction IDA
IDA: 通过直接分析推断
17053831 MGI
acts upstream of or within positive regulation of cell-matrix adhesion IGI
IGI: 通过遗传相互作用推断
17053831 MGI
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
30687013 MGI
acts upstream of or within positive regulation of leukocyte migration IGI
IGI: 通过遗传相互作用推断
17053831 MGI
acts upstream of or within positive regulation of macrophage differentiation IMP
IMP: 通过突变表型推断
9215625 MGI
acts upstream of or within positive regulation of monocyte differentiation IMP
IMP: 通过突变表型推断
9215625 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: 通过突变表型推断
12865350 MGI
acts upstream of or within positive regulation of odontogenesis of dentin-containing tooth IMP
IMP: 通过突变表型推断
12865350 MGI
acts upstream of or within positive regulation of osteoclast differentiation IDA
IDA: 通过直接分析推断
15657444 MGI
acts upstream of or within positive regulation of osteoclast differentiation IGI
IGI: 通过遗传相互作用推断
17053831 MGI
acts upstream of or within positive regulation of osteoclast differentiation IMP
IMP: 通过突变表型推断
9215625 MGI
acts upstream of or within positive regulation of protein kinase activity IGI
IGI: 通过遗传相互作用推断
17053831 MGI
acts upstream of or within regulation of ossification IMP
IMP: 通过突变表型推断
12865350 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CSF1-CSF1R complex IDA
IDA: 通过直接分析推断
19017797 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

macrophage colony-stimulating factor 1

osteopetrosis

重组 Csf1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7085 M-CSF Protein, Mouse P07141 (K33-P187) ≥95%
HY-P7085A M-CSF Protein, Mouse (CHO) P07141 (K33-P187) ≥95%
HY-P70553 M-CSF Protein, Mouse (HEK293) P07141-1 (K33-E262) ≥95%
HY-P700222AF Animal-Free M-CSF Protein, Mouse (His) P07141 (K33-P187) ≥95%
HY-P70263A M-CSF Protein, Mouse (HEK293, C-His) P07141-1 (K33-E262) ≥95%

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-16749 Pexidartinib 99.64% 是
HY-16749A Pexidartinib hydrochloride 99.86% 是
HY-12297 Sulfatinib Inhibitor 99.52% 否
Clinical Phase
生物活性分子 (14)
目录号 产品名 作用方式
纯度 Phase
HY-50905 Dovitinib Inhibitor 99.88% Phase 3
HY-124526 Chiauranib Inhibitor 99.28% Phase 3
HY-12768 Sotuletinib Inhibitor 99.83% Phase 2
HY-111787 Elzovantinib Inhibitor 99.93% Phase 2
HY-12768A Sotuletinib hydrochloride Inhibitor 98.84% Phase 2
HY-109086 Edicotinib Inhibitor 98.78% Phase 2
HY-109190 Seralutinib Inhibitor 99.94% Phase 2
HY-136362 ARRY-382 Inhibitor 99.63% Phase 2
HY-152830A Adrixetinib TFA Inhibitor 99.82% Phase 2
HY-152830 Adrixetinib Inhibitor 99.51% Phase 2
HY-114153 PLX5622 Inhibitor 99.95% Phase 1
HY-114153A PLX5622 hemifumarate Inhibitor 99.88% Phase 1
HY-101768 PRN1371 Inhibitor 99.43% Phase 1
HY-10204 OSI-930 98.57% Phase 1
抗体抑制剂 (4)
目录号 产品名 作用方式
纯度 Phase
HY-P99245 Emactuzumab Inhibitor 97.60% Phase 3
HY-P99259 Cabiralizumab Inhibitor 99.59% Phase 2
HY-P99452 Axatilimab Inhibitor 99.59% Phase 2
HY-P990619 LY3022855 / Phase 2
Pre-clinical Phase
生物活性分子 (58)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-132166 M4205 Inhibitor 99.47% 否
HY-101774 CSF1R-IN-1 Inhibitor 98.11% 否
HY-10408 Ki20227 Inhibitor 99.51% 否
HY-117244 AZD7507 Inhibitor 99.57% 否
HY-153920 Pimicotinib Inhibitor 99.69% 否
HY-132935 BPR1R024 Inhibitor 99.06% 否
HY-122906 JTE-952 Inhibitor 99.95% 否
HY-117273 AZ304 Inhibitor 99.96% 否
HY-126297 c-Fms-IN-10 Inhibitor 98.63% 否
HY-139990 CSF1R-IN-3 Inhibitor 98.26% 否
HY-147615 CSF1R-IN-12 98.75% 否
HY-161025 SYHA1813 Inhibitor 99.46% 否
HY-112451 cFMS Receptor Inhibitor II Inhibitor 99.88% 否
HY-159108 AZ683 Inhibitor 98.57% 否
HY-159838 Enrupatinib Inhibitor 98.90% 否
HY-160842 CSF1R-IN-24 Inhibitor 98.10% 否
HY-13493 AC710 Inhibitor 99.13% 否
HY-119942 c-Fms-IN-8 Inhibitor 99.47% 否
HY-101526 GENZ-882706 Inhibitor / 否
HY-145809 FASN-IN-5 Inhibitor 99.81% 否
HY-132935A BPR1R024 mesylate Inhibitor / 否
HY-13075 c-Fms-IN-3 Inhibitor 99.69% 否
HY-101034 CHMFL-ABL/KIT-155 / 否
HY-12768B Sotuletinib dihydrochloride Inhibitor / 否
HY-109086A Edicotinib hydrochloride Inhibitor / 否
HY-112446 ST638 Inhibitor / 否
HY-144040 CSF1R-IN-4 / 否
HY-144041 CSF1R-IN-5 Inhibitor / 否
HY-144042 CSF1R-IN-6 / 否
HY-147608 CSF1R-IN-7 Inhibitor / 否
HY-147609 CSF1R-IN-8 Inhibitor / 否
HY-147610 CSF1R-IN-9 Inhibitor / 否
HY-147611 CSF1R-IN-10 Inhibitor / 否
HY-147616 CSF1R-IN-13 / 否
HY-147617 CSF1R-IN-14 / 否
HY-153012 Axl/Mer/CSF1R-IN-1 Inhibitor / 否
HY-153243 IACS-9439 Inhibitor / 否
HY-153277 Axl/Mer/CSF1R-IN-2 Inhibitor / 否
HY-153920A Pimicotinib hydrochloride Inhibitor / 否
HY-155001 CSF1R-IN-15 Inhibitor / 否
HY-155550 CSF1R-IN-17 Antagonist / 否
HY-157422 CSF1R-IN-19 Inhibitor / 否
HY-157996 CSF1R-IN-21 Inhibitor / 否
HY-158050 PXB17 Inhibitor / 否
HY-158148 CSF1R-IN-23 Inhibitor / 否
HY-158363 CSF1R-IN-25 Inhibitor / 否
HY-161084 CSF1R-IN-18 Inhibitor / 否
HY-162309 CSF1R-IN-20 Inhibitor / 否
HY-162415 CSF1R-IN-22 / 否
HY-RS03227 CSF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03228 CSF1R Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03229 Csf1r Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03230 Csf1r Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-125086 Leustroducsin B Inducer / 否
HY-13493A AC710 Mesylate Inhibitor / 否
HY-13496 JNJ-28312141 Inhibitor / 否
HY-159503A Segigratinib hydrochloride Inhibitor / 否
HY-164529 SJ-C1044 Inhibitor / 否
抗体抑制剂 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990125 Anti-Mouse (CSF1R/CD115) Antibody (AFS98) 99.38% 否
HY-P99368 Lacnotuzumab Inhibitor 99.36% 否
HY-P991048 AMG-820 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Csf1 NCBI NCBI:1435
Macaca fascicularis Csf1 NCBI NCBI:102141631
Rattus norvegicus Csf1 NCBI NCBI:78965
Macaca mulatta Csf1 NCBI NCBI:702532
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