Csf1r - colony stimulating factor 1 receptor Gene

中文名称：集落刺激因子1 受体

种属: Mus musculus

同用名: Fms; Fim2; CD115; Csfmr; Fim-2; CSF-1R; M-CSFR; M-CSF-R

基因 ID: 12978 | 基因类型: protein coding

关于 Csf1r

Chromosome 18: 61,233,670-61,265,221 forward strand.GRCm39:CM001011.3

This gene has 6 transcripts (splice variants), 273 orthologues, 53 paralogues and is associated with 73 phenotypes. Broad expression in spleen adult (RPKM 69.7), placenta adult (RPKM 34.8) and 23 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括巨噬细胞集落刺激因子受体活性；蛋白质同二聚化活性；和蛋白磷酸酶结合活性。参与多个过程，包括神经系统发育；蛋白质磷酸化的正调节；和蛋白质磷酸化。位于细胞表面和质膜。 CSF1-CSF1R 复合体的一部分。以多种结构表达，包括消化系统；中枢神经系统;胚外成分；泌尿生殖系统；和肢体。该基因的人类直系同源物与轴突球体和色素性胶质细胞和肾细胞癌的成人发病白质脑病有关。与人 CSF1R（集落刺激因子 1 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including macrophage colony-stimulating factor receptor activity; protein homodimerization activity; and protein Phosphatase binding activity. Involved in several processes, including nervous system development; positive regulation of protein phosphorylation; and protein phosphorylation. Located in cell surface and plasma membrane. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and limb. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Csf1r 基因产物(1)

mRNA	Protein	Name
NM_001037859.2	NP_001032948.2	macrophage colony-stimulating factor 1 receptor precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cytokine binding	IDA IDA: 通过直接分析推断	8007983	MGI
enables cytokine binding	IPI IPI: 通过物理相互作用推断	19017797	MGI
enables macrophage colony-stimulating factor receptor activity	IDA IDA: 通过直接分析推断	19100238	MGI
enables macrophage colony-stimulating factor receptor activity	IMP IMP: 通过突变表型推断	8007983	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	2408759	MGI
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	19017797	MGI
enables protein phosphatase binding	IPI IPI: 通过物理相互作用推断	16705167	MGI
enables transmembrane receptor protein tyrosine kinase activity	IDA IDA: 通过直接分析推断	2408759	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in axon guidance	IMP IMP: 通过突变表型推断	22542597	MGI
involved in cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: 通过直接分析推断	19100238	MGI
involved in cell surface receptor protein tyrosine kinase signaling pathway	IMP IMP: 通过突变表型推断	8262059	MGI
involved in cellular response to cytokine stimulus	IMP IMP: 通过突变表型推断	20504948	MGI
involved in cellular response to macrophage colony-stimulating factor stimulus	IMP IMP: 通过突变表型推断	8007983	MGI
involved in forebrain neuron differentiation	IMP IMP: 通过突变表型推断	22542597	MGI
involved in macrophage colony-stimulating factor signaling pathway	IDA IDA: 通过直接分析推断	19017797	MGI
involved in microglial cell proliferation	IGI IGI: 通过遗传相互作用推断	23392676	MGI
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	22542597	MGI
involved in negative regulation of cell population proliferation	IMP IMP: 通过突变表型推断	22542597	MGI
involved in olfactory bulb development	IMP IMP: 通过突变表型推断	22542597	MGI
involved in osteoclast differentiation	IMP IMP: 通过突变表型推断	17121910	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: 通过直接分析推断	8007983	MGI
involved in positive regulation by host of viral process	IGI IGI: 通过遗传相互作用推断	20889566	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	8007983	MGI
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	8007983	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: 通过突变表型推断	21610095	MGI
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: 通过突变表型推断	8007983	MGI
involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	8007983	MGI
involved in regulation of actin cytoskeleton organization	IMP IMP: 通过突变表型推断	21610095	MGI
involved in regulation of cell shape	IMP IMP: 通过突变表型推断	21610095	MGI
involved in regulation of macrophage migration	IMP IMP: 通过突变表型推断	21610095	MGI
involved in response to ischemia	IDA IDA: 通过直接分析推断	8922060	MGI
involved in ruffle organization	IMP IMP: 通过突变表型推断	21610095	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CSF1-CSF1R complex	IDA IDA: 通过直接分析推断	19017797	MGI
located in cell surface	IDA IDA: 通过直接分析推断	8007983	MGI
located in membrane	IDA IDA: 通过直接分析推断	2408759	MGI
located in plasma membrane	IDA IDA: 通过直接分析推断	15860730	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Csf1r 蛋白结构

IG_like

Ig_3

PTKc_CSF-1R

0
200
400
600
800
977 a.a.

蛋白主名

其他名称

macrophage colony-stimulating factor 1 receptor

CSF-1 receptor	CSF-1-R
c-fms	proto-oncogene c-Fms
proto-oncogene fms

重组 Csf1r 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72951	CSF1R Protein, Mouse (HEK293, Fc)	P09581 (A20-S511)	≥95%
HY-P72953	CSF1R Protein, Mouse (Biotinylated, HEK293, His)	P09581 (A20-S511)	≥95%
HY-P72952	CSF1R Protein, Mouse (HEK293, His)	P09581 (A20-S511)	≥95%

Csf1r 抗体

目录号	产品名	应用	反应物种
HY-P83460	M-CSF Receptor Antibody (YA3205)	WB	Human

相关产品

Approval

生物活性分子 (3)

目录号	产品名	作用方式	纯度	是否罕见病
HY-16749	Pexidartinib		99.64%	是
HY-16749A	Pexidartinib hydrochloride		99.86%	是
HY-12297	Sulfatinib	Inhibitor	99.52%	否

Clinical Phase

生物活性分子 (14)

目录号	产品名	作用方式	纯度	Phase
HY-50905	Dovitinib	Inhibitor	99.88%	Phase 3
HY-124526	Chiauranib	Inhibitor	99.28%	Phase 3
HY-12768	Sotuletinib	Inhibitor	99.80%	Phase 2
HY-109086	Edicotinib	Inhibitor	98.78%	Phase 2
HY-111787	Elzovantinib	Inhibitor	99.93%	Phase 2
HY-12768A	Sotuletinib hydrochloride	Inhibitor	98.84%	Phase 2
HY-109190	Seralutinib	Inhibitor	99.94%	Phase 2
HY-136362	ARRY-382	Inhibitor	99.63%	Phase 2
HY-152830A	Adrixetinib TFA	Inhibitor	99.82%	Phase 2
HY-152830	Adrixetinib	Inhibitor	99.51%	Phase 2
HY-114153	PLX5622	Inhibitor	99.95%	Phase 1
HY-114153A	PLX5622 hemifumarate	Inhibitor	99.88%	Phase 1
HY-101768	PRN1371	Inhibitor	99.43%	Phase 1
HY-10204	OSI-930		98.57%	Phase 1

抗体抑制剂 (4)

目录号	产品名	作用方式	纯度	Phase
HY-P99245	Emactuzumab	Inhibitor	97.60%	Phase 3
HY-P99259	Cabiralizumab	Inhibitor	99.59%	Phase 2
HY-P99452	Axatilimab	Inhibitor	99.59%	Phase 2
HY-P99368	Lacnotuzumab	Inhibitor	/	Phase 2

Pre-clinical Phase

生物活性分子 (55)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-114153C	PLX5622 in AIN-76A Diet (1200 ppm)	Inhibitor	/	否
HY-10408	Ki20227	Inhibitor	99.17%	否
HY-101774	CSF1R-IN-1	Inhibitor	98.11%	否
HY-153920	Pimicotinib	Inhibitor	99.69%	否
HY-100491	H3B-6527	Inhibitor	≥98.0%	否
HY-117244	AZD7507	Inhibitor	99.57%	否
HY-132935	BPR1R024	Inhibitor	99.06%	否
HY-122906	JTE-952	Inhibitor	99.95%	否
HY-117273	AZ304	Inhibitor	99.96%	否
HY-126297	c-Fms-IN-10	Inhibitor	98.63%	否
HY-139990	CSF1R-IN-3	Inhibitor	98.26%	否
HY-147615	CSF1R-IN-12		98.75%	否
HY-161025	SYHA1813	Inhibitor	99.46%	否
HY-112451	cFMS Receptor Inhibitor II	Inhibitor	99.88%	否
HY-159108	AZ683	Inhibitor	98.57%	否
HY-159838	Enrupatinib	Inhibitor	98.90%	否
HY-13493	AC710	Inhibitor	99.13%	否
HY-119942	c-Fms-IN-8	Inhibitor	99.47%	否
HY-101526	GENZ-882706	Inhibitor	/	否
HY-160842	CSF1R-IN-24	Inhibitor	98.10%	否
HY-132935A	BPR1R024 mesylate	Inhibitor	/	否
HY-13075	c-Fms-IN-3	Inhibitor	99.69%	否
HY-101034	CHMFL-ABL/KIT-155		/	否
HY-12768B	Sotuletinib dihydrochloride	Inhibitor	/	否
HY-109086A	Edicotinib hydrochloride	Inhibitor	/	否
HY-144040	CSF1R-IN-4		/	否
HY-144041	CSF1R-IN-5	Inhibitor	/	否
HY-144042	CSF1R-IN-6		/	否
HY-147608	CSF1R-IN-7	Inhibitor	/	否
HY-147609	CSF1R-IN-8	Inhibitor	/	否
HY-147610	CSF1R-IN-9	Inhibitor	/	否
HY-147611	CSF1R-IN-10	Inhibitor	/	否
HY-147616	CSF1R-IN-13		/	否
HY-147617	CSF1R-IN-14		/	否
HY-153012	Axl/Mer/CSF1R-IN-1	Inhibitor	/	否
HY-153243	IACS-9439	Inhibitor	/	否
HY-153277	Axl/Mer/CSF1R-IN-2	Inhibitor	/	否
HY-153920A	Pimicotinib hydrochloride	Inhibitor	/	否
HY-155001	CSF1R-IN-15	Inhibitor	/	否
HY-155550	CSF1R-IN-17	Antagonist	/	否
HY-157422	CSF1R-IN-19	Inhibitor	/	否
HY-157996	CSF1R-IN-21	Inhibitor	/	否
HY-158050	PXB17	Inhibitor	/	否
HY-158148	CSF1R-IN-23	Inhibitor	/	否
HY-158363	CSF1R-IN-25	Inhibitor	/	否
HY-161084	CSF1R-IN-18	Inhibitor	/	否
HY-162309	CSF1R-IN-20	Inhibitor	/	否
HY-162415	CSF1R-IN-22		/	否
HY-RS03228	CSF1R Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS03229	Csf1r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS03230	Csf1r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-13493A	AC710 Mesylate	Inhibitor	/	否
HY-13496	JNJ-28312141	Inhibitor	/	否
HY-159503A	Segigratinib hydrochloride	Inhibitor	/	否
HY-164529	SJ-C1044	Inhibitor	/	否

抗体抑制剂 (1)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990125	Anti-Mouse (CSF1R/CD115) Antibody (AFS98)		99.38%	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Csf1r	NCBI	NCBI:1436
Macaca fascicularis	Csf1r	NCBI	NCBI:102124214
Rattus norvegicus	Csf1r	NCBI	NCBI:307403
Macaca mulatta	Csf1r	NCBI	NCBI:711512

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