2. Gene
  3. Il2 - interleukin 2 Gene

Il2 - interleukin 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：白细胞介素 2

种属: Mus musculus

同用名: Il-2

基因 ID: 16183 | 基因类型: protein coding

关于 Il2

Chromosome 3: 37,174,672-37,180,108 reverse strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 89 orthologues and is associated with 95 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白可启动细胞因子活性和白细胞介素 2 受体结合活性。参与 T 辅助 17 细胞分化的负调节。在几个过程的上游或内部起作用，包括在没有配体的情况下的外在凋亡信号通路；大分子代谢过程的正向调控；和淋巴细胞活化的调节。位于细胞外空间。在肝脏中表达；网膜囊;胸腺;和胸腺原基。用于研究干燥综合征和炎症性肠病。该基因的人类直系同源物与多种疾病有关，包括 Takayasu 动脉炎；听觉系统疾病（多种）；自身免疫性疾病（多种）；癌（多发性）；和神经退行性疾病（多种）。与人 IL2（白细胞介素 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cytokine activity and interleukin-2 receptor binding activity. Involved in negative regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2). [provided by Alliance of Genome Resources, Apr 2022]

Il2 基因产物(1)

mRNA Protein Name
NM_008366.3 NP_032392.1 interleukin-2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytokine activity IDA
IDA: 通过直接分析推断
1588041 MGI
enables cytokine activity IMP
IMP: 通过突变表型推断
12874832 MGI
enables interleukin-2 receptor binding IDA
IDA: 通过直接分析推断
1588041 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of T cell proliferation IDA
IDA: 通过直接分析推断
1588041 MGI
acts upstream of activated T cell proliferation IDA
IDA: 通过直接分析推断
7584142 MGI
acts upstream of activated T cell proliferation IMP
IMP: 通过突变表型推断
1830926 MGI
acts upstream of or within cellular response to biotic stimulus IDA
IDA: 通过直接分析推断
23262141 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: 通过直接分析推断
12082633 MGI
acts upstream of or within gene expression IDA
IDA: 通过直接分析推断
28396406 MGI
acts upstream of lymphocyte proliferation IMP
IMP: 通过突变表型推断
16227984 MGI
involved in negative regulation of T-helper 17 cell differentiation IGI
IGI: 通过遗传相互作用推断
25642768 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
7589135 MGI
acts upstream of or within negative regulation of lymphocyte proliferation IMP
IMP: 通过突变表型推断
16227984 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: 通过直接分析推断
1588041 MGI
acts upstream of or within positive regulation of T cell proliferation IMP
IMP: 通过突变表型推断
22968459 MGI
acts upstream of or within positive regulation of activated T cell proliferation IDA
IDA: 通过直接分析推断
7584142 MGI
acts upstream of or within positive regulation of activated T cell proliferation IMP
IMP: 通过突变表型推断
1830926 MGI
acts upstream of or within positive regulation of immunoglobulin production IMP
IMP: 通过突变表型推断
1830926 MGI
acts upstream of or within positive regulation of isotype switching to IgG isotypes IMP
IMP: 通过突变表型推断
1830926 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10485657 MGI
acts upstream of or within positive regulation of type II interferon production IDA
IDA: 通过直接分析推断
17213291 MGI
acts upstream of or within positive regulation of tyrosine phosphorylation of STAT protein IDA
IDA: 通过直接分析推断
10485657 MGI
acts upstream of or within regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
16227984 MGI
acts upstream of or within regulation of T cell homeostatic proliferation IMP
IMP: 通过突变表型推断
16227984 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10485657 MGI
acts upstream of tyrosine phosphorylation of STAT protein IDA
IDA: 通过直接分析推断
10485657 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
1830926 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Il2 蛋白结构

IL2

IL2: smart00189 (0 - 167)

  • 0
  • 100
  • 169 a.a.
蛋白主名 其他名称

interleukin-2

T-cell growth factor

TCGF

重组 Il2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7077 IL-2 Protein, Mouse P04351 (A21-Q169) ≥95%
HY-P78151 IL-2 Protein, Mouse (Biotinylated, HEK293, His-Avi) P04351 (A21-Q169) ≥95%
HY-P78312 IL-2 Protein, Mouse (HEK293, His-Avi) P04351 (A21-Q169) ≥95%
HY-P70646AF Animal-Free IL-2 Protein, Mouse (His) P04351 (A21-Q169) ≥95%

相关产品

Approval
生物活性分子 (7)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13756 Tacrolimus 99.93% 否
HY-A0003 Lenalidomide Inducer 99.95% 是
HY-B1046 Clofazimine 99.79% 否
HY-13756A Tacrolimus monohydrate 99.67% 是
HY-B0722 Histamine dihydrochloride Inhibitor 99.51% 是
HY-A0003B Lenalidomide hemihydrate Inducer 99.67% 是
HY-A0003A Lenalidomide hydrochloride / 否
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-108738 Daclizumab Inhibitor 95.00% 否
Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-N0594 Deacetylasperulosidic Acid Inhibitor 99.86% Phase 4
HY-113271 5-Androstenetriol Activator / Phase 4
HY-153220 NX-2127 Inhibitor 99.72% Phase 1
HY-132304 CC-90005 Inhibitor 99.67% Phase 1
抗体抑制剂 (9)
目录号 产品名 作用方式
纯度 Phase
HY-P99664 Inolimomab Inhibitor 98.78% Phase 3
HY-P99499 Cetrelimab ≥99.0% Phase 3
HY-P99410 Ordesekimab Inhibitor 95.00% Phase 2
HY-P99752 Nemvaleukin alfa 99.50% Phase 2
HY-P99902 Simlukafusp alfa Inhibitor 95.90% Phase 2
HY-P99328 Tucotuzumab ≥95.0% Phase 2
HY-P99728 Melredableukin alfa / Phase 2
HY-P99479 Bifikafusp alfa Inhibitor / Phase 2
HY-P99498 Cergutuzumab amunaleukin Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (85)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N6607 Tryptanthrin 99.89% 否
HY-138568 HPK1-IN-3 Inhibitor 99.32% 否
HY-110177 SP-100030 Inhibitor 99.86% 否
HY-110117 BIRT 377 Inhibitor 98.07% 否
HY-18303 AMG-47a Inhibitor 99.34% 否
HY-131140 BD750 Inhibitor 99.10% 否
HY-133987 AP-1/NF-κB activation inhibitor 1 Inhibitor 99.03% 否
HY-113618B RO2959 monohydrochloride Inhibitor 98.21% 否
HY-N0600 Ginsenoside F3 Modulator 99.84% 否
HY-134820 MLT-943 Inhibitor 99.77% 否
HY-126328 PKC-theta inhibitor 1 Inhibitor 99.73% 否
HY-119424 SP4206 Inhibitor 98.55% 否
HY-162734 BRD5075 Inhibitor 98.08% 否
HY-13756S Tacrolimus-13C,d2 98.36% 否
HY-21293 SU5201 Inhibitor 99.45% 否
HY-P3143A BMSpep-57 hydrochloride Inhibitor 99.69% 否
HY-106755 Tucaresol Inhibitor 98.95% 否
HY-P1997 Ferrichrome Iron-free ≥99.0% 否
HY-113618A RO2959 hydrochloride Inhibitor / 否
HY-P1453A CMD178 TFA Inhibitor 98.61% 否
HY-112778 NFAT Transcription Factor Regulator-1 Inhibitor 99.37% 否
HY-150051 IL-2-IN-1 Inhibitor 99.95% 否
HY-A0003S Lenalidomide-d5 Inducer 99.32% 否
HY-P3143 BMSpep-57 Inhibitor 99.84% 否
HY-164756 PKCTheta-IN-2 Inhibitor 99.49% 否
HY-100849 JAK 3i Inhibitor / 否
HY-108161 LF 1695 Activator / 否
HY-110113 CTA056 Inhibitor / 否
HY-112335 Lck Inhibitor III Inhibitor / 否
HY-115756 4-Maleimidosalicylic acid / 否
HY-117843 Ppc-1 / 否
HY-121743 Ro26-4550 Antagonist / 否
HY-121874 EP009 Inhibitor / 否
HY-141864 ITK/TRKA-IN-1 Inhibitor / 否
HY-142648A (R)-MLT-985 Inhibitor / 否
HY-145675A (R)-TCB2 / 否
HY-147504 Anticancer agent 63 / 否
HY-149206 HPK1-IN-33 Inhibitor / 否
HY-149232 HPK1-IN-35 Inhibitor / 否
HY-149916 A2AR-antagonist-1 Antagonist / 否
HY-149917 ITK degrader 1 Degrader / 否
HY-153952 Immuno modulator-1 Inhibitor / 否
HY-156149 CYP51/PD-L1-IN-1 Inhibitor / 否
HY-156150 CYP51/PD-L1-IN-2 Inhibitor / 否
HY-156151 CYP51/PD-L1-IN-3 Inhibitor / 否
HY-157569 PD1-PDL1-IN 2 / 否
HY-157838 HMC-B17 Inhibitor / 否
HY-159892 PD-1/PD-L1-IN-54 / 否
HY-159902 KRN7000 analog 3 Activator / 否
HY-161389 SP-alkyne Inhibitor / 否
HY-163194 Cbl-b-IN-16 Inhibitor / 否
HY-163496 HPK1-IN-45 Inhibitor / 否
HY-163747 VEGFR-2-IN-47 Inhibitor / 否
HY-163849 Mizoribine prodrug-1 / 否
HY-163850 Mizoribine prodrug-2 trifluoroacetate Inhibitor / 否
HY-168282 DD205-291 Degrader / 否
HY-169317 DGKζ-IN-6 Inhibitor / 否
HY-169318 DGKζ-IN-7 Inhibitor / 否
HY-A0003S2 Lenalidomide-13C5,15N Inducer / 否
HY-N12988 Dihydrobonducellin Inhibitor / 否
HY-N1726 cis-Burchellin Inhibitor / 否
HY-P10544 Humanized anti-tac (HAT) binding peptide Inhibitor / 否
HY-P3083 N-Myristoyl-Lys-Arg-Thr-Leu-Arg Inhibitor / 否
HY-P3736 Myelopeptide-2 Inducer / 否
HY-P5870 KTX-Sp2 Inhibitor / 否
HY-RS06728 IL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06729 Il2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06730 Il2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06748 IL2RA Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06749 IL2RB Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06750 IL2RG Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-101687 Nosantine racemate / 否
HY-115464 NC1153 / 否
HY-123187 AS2553627 Inhibitor / 否
HY-123590 BC12-4 Inhibitor / 否
HY-132243 NFAT Inhibitor-3 Inhibitor / 否
HY-13644 Gusperimus / 否
HY-161335 HPK1-IN-43 / 否
HY-163902 SP100030 analogue 1 Inhibitor / 否
HY-171004 KRN7000 analog 8 / 否
HY-171034 PQA-18 Inhibitor / 否
HY-B0757 Vitamin E nicotinate Inhibitor / 否
HY-N12783 Digitoxigenin-3-O-β-D-quinovoside Inhibitor / 否
HY-RS16278 IL2RB Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-P1453 CMD178 Inhibitor / 否
抗体抑制剂 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99680 Keliximab Inhibitor 98.23% 否
HY-P990281 Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) 95.00% 否
HY-P990086 Vopikitug Inhibitor / 否
HY-P991000 Imneskibart Inhibitor / 否
HY-P990450 Anti-IL-2Rb/CD122 Antibody Inhibitor / 否
HY-P990736 Efercoleukin alfa / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il2 NCBI NCBI:3558
Canis familiaris Il2 NCBI NCBI:403989
Macaca fascicularis Il2 NCBI NCBI:102129830
Susscrofa domestica Il2 NCBI
Leporidae Il2 NCBI
Rattus norvegicus Il2 NCBI NCBI:116562
Macaca mulatta Il2 NCBI NCBI:708017
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