Ros1 - Ros1 proto-oncogene Gene

中文名称：Ros1 原癌基因

种属: Mus musculus

同用名: Ros-1; c-ros

基因 ID: 19886 | 基因类型: protein coding

关于 Ros1

Chromosome 10: 51,921,817-52,071,340 reverse strand.GRCm39:CM001003.3

This gene has 4 transcripts (splice variants), 125 orthologues, 53 paralogues and is associated with 11 phenotypes. Restricted expression toward genital fat pad adult (RPKM 7.5).

功能概要

该基因编码的蛋白可启动蛋白磷酸酶结合活性。参与多个过程，包括柱状/立方形上皮细胞发育； ERK1 和 ERK2 级联的调节；和精子发生。作用于多个过程的上游或内部，包括基因表达的负调控；肽基酪氨酸自磷酸化；磷酸盐运输的调节。位于细胞表面和细胞质的核周区。以多种结构表达，包括泌尿生殖系统；肠;肺;胃;和行李箱。与人类 ROS1（ROS 原癌基因 1，受体酪氨酸激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein Phosphatase binding activity. Involved in several processes, including columnar/cuboidal epithelial cell development; regulation of ERK1 and ERK2 cascade; and spermatogenesis. Acts upstream of or within several processes, including negative regulation of gene expression; peptidyl-tyrosine autophosphorylation; and regulation of phosphate transport. Located in cell surface and perinuclear region of cytoplasm. Is expressed in several structures, including genitourinary system; intestine; lung; stomach; and trunk. Orthologous to human ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Ros1 基因产物(1)

mRNA	Protein	Name
NM_011282.2	NP_035412.2	proto-oncogene tyrosine-protein kinase ROS precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein phosphatase binding	IPI IPI: 通过物理相互作用推断	11266449	MGI
enables protein tyrosine kinase activity	IDA IDA: 通过直接分析推断	12661006	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell differentiation	IDA IDA: 通过直接分析推断	11266449	MGI
involved in columnar/cuboidal epithelial cell development	IMP IMP: 通过突变表型推断	8675006	MGI
acts upstream of or within gene expression	IMP IMP: 通过突变表型推断	12399522	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: 通过突变表型推断	12773415	MGI
acts upstream of or within peptidyl-tyrosine autophosphorylation	IDA IDA: 通过直接分析推断	7970722	MGI
involved in peptidyl-tyrosine autophosphorylation	IDA IDA: 通过直接分析推断	12661006	MGI
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	11266449	MGI
involved in regulation of ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	11266449	MGI
acts upstream of or within regulation of phosphate transport	IMP IMP: 通过突变表型推断	12773415	MGI
acts upstream of or within signal transduction	IDA IDA: 通过直接分析推断	7854358	MGI
acts upstream of or within spermatogenesis	IMP IMP: 通过突变表型推断	12773415	MGI
involved in spermatogenesis	IMP IMP: 通过突变表型推断	8675006	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	7970722	MGI
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	7970722	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ros1 蛋白结构

FN3

PTKc_c-ros

0
400
800
1200
1600
2000
2340 a.a.

蛋白主名

其他名称

proto-oncogene tyrosine-protein kinase ROS

c-Ros receptor tyrosine kinase	c-ros-1
proto-oncogene c-Ros	proto-oncogene c-Ros-1
receptor tyrosine kinase c-ros oncogene 1

相关产品

Approval

生物活性分子 (9)

目录号	产品名	作用方式	纯度	是否罕见病
HY-50878	Crizotinib		99.97%	是
HY-12215	Lorlatinib		99.92%	是
HY-12678	Entrectinib		99.79%	是
HY-W015913	Sodium 2-oxopropanoate	Inhibitor	99.86%	是
HY-103022	Repotrectinib	Inhibitor	99.93%	否
HY-50878A	Crizotinib hydrochloride		99.86%	是
HY-145574	Iruplinalkib	Inhibitor	99.62%	否
HY-12215R	Lorlatinib (Standard)		/	否
HY-50878B	Crizotinib acetate	Inhibitor	/	否

Clinical Phase

生物活性分子 (6)

目录号	产品名	作用方式	纯度	Phase
HY-15514	Merestinib	Inhibitor	99.99%	Phase 2
HY-131003	Taletrectinib	Inhibitor	99.78%	Phase 2
HY-152292	Zidesamtinib	Inhibitor	99.55%	Phase 2
HY-15514A	Merestinib dihydrochloride	Inhibitor	99.36%	Phase 2
HY-131003A	Taletrectinib free base	Inhibitor	/	Phase 2
HY-155163	APG-2449	Inhibitor	98.93%	Phase 1

Pre-clinical Phase

生物活性分子 (46)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N0578	Apigenin 7-glucoside		98.98%	否
HY-W015913S	Sodium 2-oxopropanoate-13C3	Inhibitor	99.7%	否
HY-12678S1	Entrectinib-d8		99.82%	否
HY-50878S	Crizotinib-d5		99.60%	否
HY-B1106	Tetrahydroxyquinone		≥98.0%	否
HY-N7798	Pennogenin		99.90%	否
HY-112801	F-1	Inhibitor	98.03%	否
HY-122311	Orniplabin	Inhibitor	≥95.0%	否
HY-B1106A	Tetrahydroxyquinone monohydrate		≥97.0%	否
HY-W015913R	Sodium 2-oxopropanoate (standard)	Inhibitor	99.98%	否
HY-12678S	Entrectinib-d4	Inhibitor	/	否
HY-N1306	Sideroxylin		/	否
HY-161358	FAK-IN-20		/	否
HY-135509	Lorlatinib acetate		/	否
HY-159147	SIAIS039		/	否
HY-117420	CM764	Activator	/	否
HY-120387	SMU-B	Inhibitor	/	否
HY-123454	SKF1		/	否
HY-130794	ALK/ROS1-IN-1	Inhibitor	/	否
HY-144697	p38 MAPK-IN-3		/	否
HY-147795	Nampt-IN-8		/	否
HY-150974	ROS1-IN-1	Inhibitor	/	否
HY-153743	Protein kinase inhibitor 4	Inhibitor	/	否
HY-155178	Antiproliferative agent-34	Inhibitor	/	否
HY-156360	Xanthine oxidase-IN-12	Inhibitor	/	否
HY-157391	ALK/ROS1-IN-3	Inhibitor	/	否
HY-157437	AChE/BChE-IN-16	Inhibitor	/	否
HY-158016	Antiproliferative agent-49		/	否
HY-161966	VEGFR-2-IN-52		/	否
HY-161975	ROS1-IN-2	Inhibitor	/	否
HY-162311	Anticancer agent 194		/	否
HY-162488	Laccase-IN-3	Inhibitor	/	否
HY-163280	JGB-1-155	Activator	/	否
HY-163862	PPARα agonist 3		/	否
HY-170418	ALK/ROS1-IN-5		/	否
HY-50878AS	Crizotinib-d9 hydrochloride		/	否
HY-N11887	Linocinnamarin	Inhibitor	/	否
HY-N2693	6,8-Diprenylorobol		/	否
HY-RS12135	ROS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12136	Ros1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12137	ROS1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-160172	ALK/ROS1-IN-4	Inhibitor	/	否
HY-160172A	ALK/ROS1-IN-4 hydrate	Inhibitor	/	否
HY-W587743	N1-Acetyl-5-methoxykynuramine hydrochloride	Inhibitor	/	否
HY-W927359	Fluorescein hydrazide (3,6-Dihydroxyxanthane)		/	否
HY-111416	WY-135	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Ros1	NCBI	NCBI:6098

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