Ulk1 - unc-51 like kinase 1 Gene

中文名称：unc-51 样激酶 1

种属: Mus musculus

同用名: Unc51.1; mKIAA0722

关于 Ulk1

功能概要

该基因编码的蛋白可启动 HSP90 蛋白结合活性；蛋白激酶结合活性；和蛋白丝氨酸/苏氨酸激酶活性。参与多个过程，包括细胞对氨基酸饥饿的反应；巨自噬；和对线粒体去极化的反应。作用于多个过程的上游或内部，包括神经系统发育；蛋白质自身磷酸化；神经营养蛋白 Trk 受体信号通路的调控。位于几种细胞成分中，包括细胞质囊泡膜；神经细胞体；和吞噬泡组装位点膜。 Atg1/ULK1 激酶复合物的一部分。在多种结构中表达，包括中枢神经系统和视网膜。与人类 ULK1（unc-51 样自噬激活激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables HSP90 protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to amino acid starvation; macroautophagy; and response to mitochondrial depolarisation. Acts upstream of or within several processes, including nervous system development; protein autophosphorylation; and regulation of neurotrophin Trk Receptor signaling pathway. Located in several cellular components, including cytoplasmic vesicle membrane; neuronal cell body; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including central nervous system and retina. Orthologous to human ULK1 (unc-51 like Autophagy activating kinase 1). [provided by Alliance of Genome Resources, Apr 2022]