2. Gene
  3. HSPB7 - heat shock protein family B (small) member 7 Gene

HSPB7 - heat shock protein family B (small) member 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：热激蛋白家族 B (小) 成员 7

种属: Homo sapiens

同用名: cvHSP

基因 ID: 27129 | 基因类型: protein coding

关于 HSPB7

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:16,014,029-16,019,594 (from NCBI)

This gene has 7 transcripts (splice variants), 256 orthologues and 8 paralogues. Biased expression in heart (RPKM 547.7) and fat (RPKM 156.2).

功能概要

该基因编码一个小的热休克家族 B 成员，该成员可以与类似的热休克蛋白异源二聚化。该基因的缺陷与晚期心力衰竭有关。此外，编码的蛋白质可能是 p53 通路中的肿瘤抑制因子，该基因的缺陷与肾细胞癌有关。[RefSeq 提供，2017 年 3 月]

This gene encodes a small heat shock family B member that can heterodimerize with similar heat shock proteins. Defects in this gene are associated with advanced heart failure. In addition, the encoded protein may be a tumor suppressor in the p53 pathway, with defects in this gene being associated with renal cell carcinoma. [provided by RefSeq, Mar 2017]

HSPB7 基因产物(8)

mRNA Protein Name
NM_001349682.2 NP_001336611.1 heat shock protein beta-7 isoform 1
NM_001349683.2 NP_001336612.1 heat shock protein beta-7 isoform 3
NM_001349685.2 NP_001336614.1 heat shock protein beta-7 isoform 4
NM_001349686.2 NP_001336615.1 heat shock protein beta-7 isoform 5
NM_001349687.2 NP_001336616.1 heat shock protein beta-7 isoform 6
NM_001349688.2 NP_001336617.1 heat shock protein beta-7 isoform 7
NM_001349689.2 NP_001336618.1 heat shock protein beta-7 isoform 8
NM_014424.5 NP_055239.1 heat shock protein beta-7 isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14594798 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19464326 GOA
located in nucleus IDA
IDA: 通过直接分析推断
19464326 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HSPB7 蛋白结构

HSP20

HSP20: Hsp20/alpha crystallin family (76 - 159)

  • 0
  • 100
  • 170 a.a.
蛋白主名 其他名称

heat shock protein beta-7

cardiovascular heat shock protein

HSPB7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HSPB7 Q9UBY9 REL Homo sapiens Q04864-2
Y2H Array
32296183
种属内
HSPB7 Q9UBY9 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
种属内
HSPB7 Q9UBY9 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
种属内
HSPB7 Q9UBY9 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
种属内
HSPB7 Q9UBY9 UBXN1 Homo sapiens Q04323-2
Y2H Array
32296183
种属内
HSPB7 Q9UBY9 UBXN1 Homo sapiens Q04323-2
Y2H Prey Pooling
32296183
种属内
HSPB7 Q9UBY9 PIP4K2B Homo sapiens P78356-2
Y2H Prey Pooling
32296183
种属内
HSPB7 Q9UBY9 PIP4K2B Homo sapiens P78356-2
Y2H Array
32296183
种属内
HSPB7 Q9UBY9 DYNLT1 Homo sapiens P63172
Y2H Array
32296183
种属内
HSPB7 Q9UBY9 DYNLT1 Homo sapiens P63172
Y2H Prey Pooling
32296183
种属内
HSPB7 Q9UBY9 C22orf15 Homo sapiens Q8WYQ4-2
Y2H Array
32296183
种属内
HSPB7 Q9UBY9 C22orf15 Homo sapiens Q8WYQ4-2
Y2H Prey Pooling
32296183
种属内
HSPB7 Q9UBY9 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
种属内
HSPB7 Q9UBY9 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
种属内
HSPB7 Q9UBY9 REL Homo sapiens Q04864
Y2H Array
25416956
种属内
HSPB7 Q9UBY9 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
种属内
HSPB7 Q9UBY9 SF3B4 Homo sapiens Q15427
Validated Y2H
25416956
种属内
HSPB7 Q9UBY9 PDLIM7 Homo sapiens Q9NR12
Y2H Prey Pooling
32296183
种属内
HSPB7 Q9UBY9 PDLIM7 Homo sapiens Q9NR12
Y2H Array
32296183
种属内
HSPB7 Q9UBY9 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
25416956
种属内
HSPB7 Q9UBY9 SYCE1 Homo sapiens Q8N0S2
Y2H Prey Pooling
25416956
种属内
HSPB7 Q9UBY9 HSPB8 Homo sapiens Q9UJY1
Anti Tag CoIP
14594798
种属内
HSPB7 Q9UBY9 HSPB8 Homo sapiens Q9UJY1
Validated Y2H
32296183
种属内
HSPB7 Q9UBY9 HSPB8 Homo sapiens Q9UJY1
Y2H Array
32296183
种属内
HSPB7 Q9UBY9 HSPB8 Homo sapiens Q9UJY1
Y2H
14594798
种属内
HSPB7 Q9UBY9 HSPB8 Homo sapiens Q9UJY1
FRET
14594798
种属内
HSPB7 Q9UBY9 HSPB8 Homo sapiens Q9UJY1
Validated Y2H
25416956
种属内
HSPB7 Q9UBY9 HSPB8 Homo sapiens Q9UJY1
Y2H Prey Pooling
32296183
种属内
HSPB7 Q9UBY9 TRIM23 Homo sapiens P36406
Y2H Array
25416956
种属内
HSPB7 Q9UBY9 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
种属内
HSPB7 Q9UBY9 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
种属内
HSPB7 Q9UBY9 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
种属内
HSPB7 Q9UBY9 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
种属内
HSPB7 Q9UBY9 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
25416956
种属内
HSPB7 Q9UBY9 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
25416956
种属内
HSPB7 Q9UBY9 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
种属内
HSPB7 Q9UBY9 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
25416956
种属内
HSPB7 Q9UBY9 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
25416956
种属内
HSPB7 Q9UBY9 CEP76 Homo sapiens Q8TAP6
Validated Y2H
25416956
种属内
HSPB7 Q9UBY9 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
种属内
HSPB7 Q9UBY9 CEP76 Homo sapiens Q8TAP6
Y2H Array
25416956
种属内
HSPB7 Q9UBY9 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
种属内
HSPB7 Q9UBY9 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
种属内
HSPB7 Q9UBY9 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
种属内
HSPB7 Q9UBY9 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
种属内
HSPB7 Q9UBY9 FLNA Homo sapiens P21333-2
Anti Tag CoIP
28514442
种属内
HSPB7 Q9UBY9 FLNA Homo sapiens P21333-2
Y2H Array
32296183
种属内
HSPB7 Q9UBY9 FLNA Homo sapiens P21333-2
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 HSPB7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70929 PSG2 Protein, Human (His) Q9UBY9 (M1-I170) ≥95%

关联疾病

疾病名称 别名
Paraneoplastic Polyneuropathy
Distal Hereditary Motor Neuronopathy Type 2

Distal Hereditary Motor Neuropathy, Type Ii

Distal Hereditary Motor Neuropathy Type 2

Distal Hereditary Motor Neuropathy Type Ii

Hmn Ii

Hmn2

Distal Hereditary Motor Neuronopathy, Type Ii

Distal Spinal Muscular Atrophy Type 2

Dhmn2

Dsma2

Neuropathy, Motor, Distal, Hereditary, Type Ii

Spinal Muscular Atrophy, Jerash Type
Myopathy, Myofibrillar, 5

Myofibrillar Myopathy 5

MFM5

Myopathy, Myofibrillar, Filamin C-Related

Filaminopathy, Autosomal Dominant

Filaminopathy

Muscle Filaminopathy

Autosomal Dominant Filaminopathy

Mfm Filamin C-Related

Myopathy Myofibrillar Filamin C-Related

Myopathy, Myofibrillar, Type 5
Systolic Heart Failure

Heart Failure, Systolic
Myofibrillar Myopathy

Desmin Related Myopathy

Myotilinopathy

Myopathy, Myofibrillar

Alpha Beta Crystallinopathy

Desmin Storage Myopathy

Desminopathy

Filaminopathy

Protein Surplus Myopathy

Zaspopathy

Myofibrillar Myopathies

Myopathy, Myofibrillar, Desmin-Related

Myopathy, Desmin Storage

Mfm - [Myofibrillar Myopathy]
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06442 HSPB7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HSPB7 MGD MGI:1352494
Rattus norvegicus HSPB7 RGD RGD:62021
Macaca mulatta HSPB7 VGNC VGNC:99972
Canis familiaris HSPB7 VGNC VGNC:52138
Felis catus HSPB7 VGNC VGNC:80236
Bos taurus HSPB7 VGNC VGNC:49068
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