2. Gene
  3. Akt3 - AKT serine/threonine kinase 3 Gene

Akt3 - AKT serine/threonine kinase 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：AKT 丝氨酸/苏氨酸激酶 3

种属: Rattus norvegicus

同用名: Pkbg

基因 ID: 29414 | 基因类型: protein coding

关于 Akt3

Primary_assembly 13: 88,946,091-89,225,708 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 203 orthologues, 5 paralogues and is associated with 22 phenotypes. Biased expression in Brain (RPKM 538.7), Thymus (RPKM 188.1) and 8 other tissues.

功能概要

该基因编码的蛋白可启动 ATP 绑定活动；蛋白激酶 C 结合活性；和蛋白丝氨酸/苏氨酸激酶活性。参与蛋白质磷酸化。在细胞对胰岛素刺激的反应和钠离子转运的正调节作用的上游或细胞内起作用。预计位于胞质溶胶和核质中。与结肠癌有关的该基因的人类直系同源物；胶质母细胞瘤;前列腺癌；前列腺癌;和肾细胞癌。与人类 AKT3（AKT 丝氨酸/苏氨酸激酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in protein phosphorylation. Acts upstream of or within cellular response to Insulin stimulus and positive regulation of sodium ion transport. Predicted to be located in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human Akt3 (Akt serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Akt3 基因产物(1)

mRNA Protein Name
NM_031575.2 NP_113763.2 RAC-gamma serine/threonine-protein kinase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
9887206 RGD
enables protein kinase C binding IPI
IPI: 通过物理相互作用推断
7488143 RGD
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
7488143 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to insulin stimulus IMP
IMP: 通过突变表型推断
17715136 RGD
acts upstream of or within positive regulation of sodium ion transport IMP
IMP: 通过突变表型推断
17715136 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
9887206 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Akt3 蛋白结构

PH_PKB

PH_PKB: cd01241 (3 - 132)

PKc_like

PKc_like: cl21453 (174 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
蛋白主名 其他名称

RAC-gamma serine/threonine-protein kinase

AKT3 kinase

PKB gamma

RAC-PK-gamma

protein kinase Akt-3

protein kinase B, gamma

thymoma viral proto-oncogene 3

v-akt murine thymoma viral oncogene 3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

相关产品

Clinical Phase
生物活性分子 (20)
目录号 产品名 作用方式
纯度 Phase
HY-15186 Ipatasertib Inhibitor 99.88% Phase 4
HY-15186A Ipatasertib dihydrochloride Inhibitor 99.27% Phase 4
HY-15431 Capivasertib Inhibitor 99.95% Phase 3
HY-10358 MK-2206 dihydrochloride Inhibitor 99.99% Phase 2
HY-19719 Miransertib Inhibitor 99.32% Phase 2
HY-15727 Afuresertib Inhibitor 99.53% Phase 2
HY-15965 Uprosertib Inhibitor 99.74% Phase 2
HY-19934A Pifusertib hydrochloride Inhibitor 96.71% Phase 2
HY-15727A Afuresertib hydrochloride Inhibitor 99.95% Phase 2
HY-19719A Miransertib hydrochloride Inhibitor 99.74% Phase 2
HY-108232 MK-2206 Inhibitor / Phase 2
HY-19934 Pifusertib Inhibitor / Phase 2
HY-10357 MK-2206 free base Inhibitor / Phase 2
HY-15965A Uprosertib hydrochloride Inhibitor / Phase 2
HY-10249 GSK-690693 Inhibitor 98.46% Phase 1
HY-100018 BAY1125976 Inhibitor 99.52% Phase 1
HY-16071 AT13148 Inhibitor 99.21% Phase 1
HY-100501 M2698 Inhibitor 99.87% Phase 1
HY-137458 Vevorisertib Inhibitor / Phase 1
HY-15186C Ipatasertib tosylate Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (19)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10355 AKT inhibitor VIII Inhibitor 98.97% 否
HY-10425 A-443654 Inhibitor 99.71% 否
HY-12059 AT7867 Inhibitor 99.88% 否
HY-137458A Vevorisertib trihydrochloride Inhibitor 99.13% 否
HY-133120 INY-03-041 Inhibitor 99.74% 否
HY-151504 ALM301 Inhibitor 99.33% 否
HY-145282 MS170 Inhibitor 99.72% 否
HY-12059A AT7867 dihydrochloride Inhibitor 99.75% 否
HY-19982 AKT-IN-6 Inhibitor 99.08% 否
HY-126257 AKT-IN-3 Inhibitor 99.29% 否
HY-133120A INY-03-041 trihydrochloride Inhibitor 99.27% 否
HY-151613 MS15 Inhibitor / 否
HY-132302 Hu7691 Inhibitor / 否
HY-129119 Akt1/Akt2-IN-2 Inhibitor 98.57% 否
HY-145281 MS98 Inhibitor / 否
HY-132302A Hu7691 free base Inhibitor / 否
HY-147937 AKT-IN-13 Inhibitor / 否
HY-143611 AKT-IN-8 Inhibitor / 否
HY-16032 Akt1-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Akt3 NCBI NCBI:10000
Mus musculus Akt3 NCBI NCBI:23797
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