MAGOH - mago homolog, exon junction complex subunit Gene

中文名称：mago 同系物，外显子连接复合亚基

种属: Homo sapiens

同用名: MAGOH1; MAGOHA

基因 ID: 4116 | 基因类型: protein coding

关于 MAGOH

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:53,226,900-53,238,518 (from NCBI)

This gene has 4 transcripts (splice variants), 215 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 28.8), colon (RPKM 24.3) and 25 other tissues.

功能概要

其 mago nashi (无孙) 基因发生突变的果蝇产生的后代在种质组装和种系发育方面存在缺陷。该基因编码哺乳动物 mago nashi 同系物。在哺乳动物中，mRNA 表达不限于种质，而是在成体组织中普遍表达，并且可以通过静止成纤维细胞的血清刺激来诱导。[RefSeq 提供，2008 年 7 月]

Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]

MAGOH 基因产物(1)

mRNA	Protein	Name
NM_002370.4	NP_002361.1	protein mago nashi homolog

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10662555	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IGI IGI: 通过遗传相互作用推断	23917022	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP IMP: 通过突变表型推断	16209946	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IMP IMP: 通过突变表型推断	22203037	GOA
involved in regulation of mRNA processing	IDA IDA: 通过直接分析推断	23115303	GOA
involved in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: 通过直接分析推断	19478851	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of catalytic step 2 spliceosome	IDA IDA: 通过直接分析推断	11991638	GOA
part of exon-exon junction complex	IDA IDA: 通过直接分析推断	16601204	GOA
part of exon-exon junction complex	IPI IPI: 通过物理相互作用推断	16931718	GOA
part of exon-exon junction subcomplex mago-y14	IPI IPI: 通过物理相互作用推断	12781131	GOA
located in nucleus	IDA IDA: 通过直接分析推断	22720776	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAGOH 蛋白结构

Mago_nashi

0
100
146 a.a.

蛋白主名

其他名称

protein mago nashi homolog

mago homolog, exon junction complex core component

MAGOH 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MAGOH	P61326	DPH2	Homo sapiens	Q9BQC3	Validated Y2H	32296183
种属内	MAGOH	P61326	DPH2	Homo sapiens	Q9BQC3	Y2H Array	32296183
种属内	MAGOH	P61326	DPH2	Homo sapiens	Q9BQC3	Y2H Prey Pooling	32296183
种属内	MAGOH	P61326	PPP1R16B	Homo sapiens	Q96T49	Y2H Prey Pooling	32296183
种属内	MAGOH	P61326	PPP1R16B	Homo sapiens	Q96T49	Validated Y2H	32296183
种属内	MAGOH	P61326	PPP1R16B	Homo sapiens	Q96T49	Y2H Array	32296183
种属内	MAGOH	P61326	FXR1	Homo sapiens	P51114-2	Y2H Prey Pooling	32296183
种属内	MAGOH	P61326	FXR1	Homo sapiens	P51114-2	Y2H Array	32296183
种属内	MAGOH	P61326	UPF3B	Homo sapiens	Q9BZI7-2	TAP	18066079
种属内	MAGOH	P61326	PYM1	Homo sapiens	Q9BRP8	Anti Tag CoIP	33961781
种属内	MAGOH	P61326	PYM1	Homo sapiens	Q9BRP8	TAP	18066079
种属内	MAGOH	P61326	PYM1	Homo sapiens	Q9BRP8	Anti Tag CoIP	16209946
种属内	MAGOH	P61326	PYM1	Homo sapiens	Q9BRP8	Anti Tag CoIP	19478851
种属内	MAGOH	P61326	PYM1	Homo sapiens	Q9BRP8	Anti Bait CoIP	19410547
种属内	MAGOH	P61326	PYM1	Homo sapiens	Q9BRP8	Anti Tag CoIP	23084401
种属内	MAGOH	P61326	ZKSCAN8	Homo sapiens	Q15776	Validated Y2H	32296183
种属内	MAGOH	P61326	ZKSCAN8	Homo sapiens	Q15776	Y2H Array	32296183
种属内	MAGOH	P61326	ZKSCAN8	Homo sapiens	Q15776	Y2H Prey Pooling	32296183
种属内	MAGOH	P61326	EIF4A3	Homo sapiens	P38919	Anti Tag CoIP	14730019
种属内	MAGOH	P61326	EIF4A3	Homo sapiens	P38919	TAP	18066079
种属内	MAGOH	P61326	EIF4A3	Homo sapiens	P38919	Anti Bait CoIP	19410547
种属内	MAGOH	P61326	EIF4A3	Homo sapiens	P38919	TAP	16170325
种属内	MAGOH	P61326	EIF4A3	Homo sapiens	P38919	Anti Tag CoIP	16209946
种属内	MAGOH	P61326	CASC3	Homo sapiens	O15234	Anti Tag CoIP	16209946
种属内	MAGOH	P61326	CASC3	Homo sapiens	O15234	Pull Down	14973490
种属内	MAGOH	P61326	CASC3	Homo sapiens	O15234	Anti Tag CoIP	19478851
种属内	MAGOH	P61326	CASC3	Homo sapiens	O15234	TAP	18066079
种属内	MAGOH	P61326	CASC3	Homo sapiens	O15234	TAP	16170325
种属内	MAGOH	P61326	CASC3	Homo sapiens	O15234	Anti Bait CoIP	19410547
种属内	MAGOH	P61326	CASC3	Homo sapiens	O15234	Anti Tag CoIP	23084401
种属内	MAGOH	P61326	UPF3B	Homo sapiens	Q9BZI7	Anti Tag CoIP	19478851
种属内	MAGOH	P61326	UPF3B	Homo sapiens	Q9BZI7	Anti Bait CoIP	19410547
种属内	MAGOH	P61326	UPF3B	Homo sapiens	Q9BZI7	Anti Tag CoIP	16209946
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Y2H Prey Pooling	32296183
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Y2H	22365833
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Anti Bait CoIP	19410547
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Anti Tag CoIP	16209946
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Lumier	29997244
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Anti Tag CoIP	14730019
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Pull Down	19410547
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Y2H Array	32296183
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	BRET	29997244
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Validated Y2H	25416956
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Validated Y2H	32296183
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Anti Tag CoIP	33961781
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Y2H	10662555
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Pull Down	12730685
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Lumier	32814053
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Y2H Prey Pooling	25416956
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Anti Tag CoIP	23084401
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Pull Down	10662555
种属内	MAGOH	P61326	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
种属内	MAGOH	P61326	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
种属内	MAGOH	P61326	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9-1	TAP	18066079
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9-1	TAP	16170325
种属内	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9-1	Anti Tag CoIP	19478851
种属内	MAGOH	P61326	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
种属内	MAGOH	P61326	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
种属内	MAGOH	P61326	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
种属内	MAGOH	P61326	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
种属内	MAGOH	P61326	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
种属内	MAGOH	P61326	DPPA4	Homo sapiens	Q7L190	Y2H Prey Pooling	32296183
种属内	MAGOH	P61326	DPPA4	Homo sapiens	Q7L190	Validated Y2H	32296183
种属内	MAGOH	P61326	DPPA4	Homo sapiens	Q7L190	Y2H Array	32296183
种属内	MAGOH	P61326	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
种属内	MAGOH	P61326	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
种属内	MAGOH	P61326	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
种属内	MAGOH	P61326	TADA2A	Homo sapiens	O75478	Validated Y2H	25416956
种属内	MAGOH	P61326	IPO13	Homo sapiens	O94829	Pull Down	21139563

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 MAGOH 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76484	MAGOH Protein, Human (His)	P61326-1/NP_002361.1 (M1-I146)	≥95%

MAGOH 抗体

目录号	产品名	应用	反应物种
HY-P82824	MAGOH Antibody (YA2569)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

关联疾病

疾病名称

别名

Metaphyseal Chondrodysplasia, Schmid Type

MCDS	Schmid Metaphyseal Chondrodysplasia
Metaphyseal Chondrodysplasia Schmid Type	Spondylometaphyseal Dysplasia, Japanese Type
Japanese Type Spondylometaphyseal Dysplasia	Schmid Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia Type Schmid	Schmid Type Metaphyseal Chondrodysplasia
SMCD	Chondrodysplasia, Metaphyseal, Schmid Type
Corneal Dystrophy, Subepithelial Mucinous

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07985	MAGOH Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	MAGOH	VGNC	VGNC:107580
Rattus norvegicus	MAGOH	RGD	RGD:1305174
Mus musculus	MAGOH	MGD	MGI:1330312
Others	MAGOH	NCBI

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