PCBP1 - poly(rC) binding protein 1 Gene

中文名称：聚 (rC) 结合蛋白 1

种属: Homo sapiens

同用名: HNRPX; HNRPE1; hnRNP-X; HEL-S-85; hnRNP-E1

关于 PCBP1

功能概要

这种无内含子的基因被认为是由完全加工的 PCBP-2 mRNA 的逆转录转座产生的。该基因和 PCBP-2 具有旁系同源物 (PCBP3 和 PCBP4) ，它们被认为是整个基因复制事件的结果。该基因编码的蛋白质似乎是多功能的。它连同 PCBP-2 和 hnRNPK 对应于主要的细胞聚 (rC) 结合蛋白。它包含三个可能参与 RNA 结合的 K 同源 (KH) 结构域。这种编码的蛋白质与 PCBP-2 一起还通过与 IRES 的茎环 IV 的序列特异性相互作用作为脊髓灰质炎病毒 RNA 的翻译共激活因子，并通过与其 5'-末端三叶草结构结合促进脊髓灰质炎病毒 RNA 复制。它还涉及 15-脂氧合酶 mRNA、人乳头瘤病毒 16 型 L2 mRNA 和甲型肝炎病毒 RNA 的翻译控制。还建议编码的蛋白质在序列特异性 α-珠蛋白 mRNP 复合物的形成中发挥作用，该复合物与 α-珠蛋白 mRNA 稳定性相关。[RefSeq 提供，2008 年 7 月]

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]