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  2. OTUB2 - OTU deubiquitinase, ubiquitin aldehyde binding 2 Gene

OTUB2 - OTU deubiquitinase, ubiquitin aldehyde binding 2 Gene

中文名称:OTU 去泛素化酶,泛素醛结合 2

种属: Homo sapiens

同用名: OTB2; OTU2; C14orf137

基因 ID: 78990 | 基因类型: protein coding

关于 OTUB2

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:94,026,340-94,048,930 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 167 orthologues and 1 paralogue. Broad expression in testis (RPKM 3.4), skin (RPKM 2.0) and 18 other tissues.

功能概要

该基因编码几种去泛素化酶中的一种。蛋白质的泛素修饰对于它们的稳定性和功能是必需的;为了逆转这个过程,去泛素化酶去除了泛素。该蛋白质包含一个 OTU 结构域并结合 Ubal (泛素醛) ; OTU 结构域中存在一个活性半胱氨酸蛋白酶位点。[RefSeq 提供,2011 年 8 月]

This gene encodes one of several deubiquitylating Enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling Enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine Protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]

OTUB2 基因产物(1)

mRNA Protein Name
NM_023112.4 NP_075601.1 ubiquitin thioesterase OTUB2

OTUB2 蛋白结构

Peptidase_C65

Peptidase_C65: Peptidase C65 Otubain (2 - 229)

  • 0
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  • 234 a.a.
蛋白主名 其他名称

ubiquitin thioesterase OTUB2

OTU domain, ubiquitin aldehyde binding 2

重组 OTUB2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71182 OTUB2 Protein, Human (GST) Q96DC9-1 (M1-H234) ≥95%
HY-P77118 OTUB2 Protein, Human (His) Q96DC9-1 (M1-H234) ≥95%

直系同源

种属 基因名 来源 基因 ID
Bos taurus OTUB2 VGNC VGNC:32492
Mus musculus OTUB2 MGD MGI:1915399
Macaca mulatta OTUB2 VGNC VGNC:75656
Rattus norvegicus OTUB2 RGD RGD:1306688
Felis catus OTUB2 VGNC VGNC:80887
Canis familiaris OTUB2 VGNC VGNC:44183
Others OTUB2 NCBI