2. Gene
  3. HDAC10 - histone deacetylase 10 Gene

HDAC10 - histone deacetylase 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：组蛋白脱乙酰酶 10

种属: Homo sapiens

同用名: HD10

基因 ID: 83933 | 基因类型: protein coding

关于 HDAC10

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,245,183-50,251,265 (from NCBI)

This gene has 22 transcripts (splice variants), 181 orthologues and 10 paralogues. Ubiquitous expression in spleen (RPKM 10.7), bone marrow (RPKM 7.4) and 25 other tissues.

功能概要

该基因编码的蛋白质属于组蛋白去乙酰化酶家族，其成员使核心组蛋白 N 末端部分的赖氨酸残基脱乙酰化。组蛋白去乙酰化调节染色质结构，并在转录调控、细胞周期进程和发育事件中发挥重要作用。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 8 月]

The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

HDAC10 基因产物(2)

mRNA Protein Name
NM_001159286.2 NP_001152758.1 polyamine deacetylase HDAC10 isoform 2
NM_032019.6 NP_114408.3 polyamine deacetylase HDAC10 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables deacetylase activity IDA
IDA: 通过直接分析推断
28516954 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
11861901 GOA
enables histone deacetylase activity IDA
IDA: 通过直接分析推断
11739383 GOA
enables histone deacetylase binding IDA
IDA: 通过直接分析推断
11861901 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17172643 GOA
NOT enables protein lysine deacetylase activity IDA
IDA: 通过直接分析推断
28516954 GOA
enables protein lysine deacetylase activity IDA
IDA: 通过直接分析推断
17172643 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in homologous recombination IMP
IMP: 通过突变表型推断
21247901 GOA
involved in macroautophagy IMP
IMP: 通过突变表型推断
23801752 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11726666 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11726666 GOA
involved in polyamine deacetylation IDA
IDA: 通过直接分析推断
28516954 GOA
involved in positive regulation of mismatch repair IDA
IDA: 通过直接分析推断
26221039 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11861901 GOA
involved in spermidine deacetylation IDA
IDA: 通过直接分析推断
28516954 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11726666 GOA
part of histone deacetylase complex IDA
IDA: 通过直接分析推断
11861901 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
11726666 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11739383 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HDAC10 蛋白结构

Hist_deacetyl

Hist_deacetyl: Histone deacetylase domain (23 - 321)

  • 0
  • 200
  • 400
  • 600
  • 669 a.a.
蛋白主名 其他名称

polyamine deacetylase HDAC10

关联疾病

疾病名称 别名
Conjugate Gaze Palsy

Palsy Of Conjugate Gaze

Supranuclear Ocular Palsy

Gaze Palsy
Spinocerebellar Ataxia, X-Linked 5

SCAX5

X-Linked Spinocerebellar Ataxia 5

X-Linked Non Progressive Cerebellar Ataxia
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-109015 Tucidinostat Inhibitor 98.60% 否
HY-13322 Pracinostat Inhibitor 99.82% 是
HY-B0494 Bufexamac Inhibitor ≥98.0% 否
Clinical Phase
生物活性分子 (11)
目录号 产品名 作用方式
纯度 Phase
HY-10990 Abexinostat Inhibitor 98.63% Phase 3
HY-14842 Givinostat Inhibitor 98.16% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-16012A Domatinostat Inhibitor 99.43% Phase 2
HY-101780 Tinostamustine Inhibitor 99.42% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 98.84% Phase 1
Pre-clinical Phase
生物活性分子 (31)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13428 Tubacin Inhibitor 99.54% 否
HY-15224 PCI-34051 Inhibitor 99.75% 否
HY-18613 CAY10603 Inhibitor ≥98.0% 否
HY-16699 Nexturastat A Inhibitor 98.28% 否
HY-111818 TH34 Inhibitor 99.52% 否
HY-115475 SW-100 Inhibitor 99.59% 否
HY-144779 HDAC10-IN-1 Inhibitor 99.11% 否
HY-19747 HPOB Inhibitor 99.80% 否
HY-110280 MC1742 Inhibitor 99.20% 否
HY-152174 HDAC-IN-52 Inhibitor 99.46% 否
HY-150109 Purinostat mesylate Inhibitor / 否
HY-161778 ZG-126 Inhibitor / 否
HY-152173 HDAC-IN-51 Inhibitor / 否
HY-157740 XSJ-10 Inhibitor / 否
HY-163834 HDAC6-IN-47 Inhibitor / 否
HY-109015S Tucidinostat-d4 Inhibitor / 否
HY-144782 HDAC10-IN-2 Inhibitor / 否
HY-147731 HDAC6-IN-9 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-152226 MC2590 Inhibitor / 否
HY-163430 HDAC-IN-71 Inhibitor / 否
HY-15144B (S)-Trichostatin A Inhibitor / 否
HY-150595 HDAC6-IN-10 Inhibitor / 否
HY-162630 HDAC6-IN-44 Inhibitor / 否
HY-152225 MC2625 Inhibitor / 否
HY-162658 Leuxinostat Inhibitor / 否
HY-19754A CRA-026440 hydrochloride Inhibitor 98.14% 否
HY-147966 HDAC-IN-43 Inhibitor / 否
HY-163803 CM-444 Inhibitor / 否
HY-146684 HDAC-IN-36 Inhibitor / 否
HY-19754 CRA-026440 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HDAC10 RGD RGD:1305874
Canis familiaris HDAC10 VGNC VGNC:50626
Macaca mulatta HDAC10 VGNC VGNC:73189
Bos taurus HDAC10 VGNC VGNC:49057
Mus musculus HDAC10 MGD MGI:2158340
Felis catus HDAC10 VGNC VGNC:82342
Others HDAC10 NCBI
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