1. Gene
  2. BOC - BOC cell adhesion associated, oncogene regulated Gene

BOC - BOC cell adhesion associated, oncogene regulated Gene

中文名称:BOC 细胞粘附相关,癌基因调节

种属: Homo sapiens

同用名: Boi; CDON2

基因 ID: 91653 | 基因类型: protein coding

关于 BOC

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:113,210,926-113,287,459 (from NCBI)

This gene has 18 transcripts (splice variants), 197 orthologues and 36 paralogues. Broad expression in skin (RPKM 11.2), prostate (RPKM 10.0) and 23 other tissues.

功能概要

该基因编码的蛋白质是免疫球蛋白/纤连蛋白 III 型重复家族的成员。它是介导肌肉前体细胞之间的细胞间相互作用并促进肌原性分化的细胞表面受体复合物的组成部分。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供,2014 年 9 月]

The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

BOC 基因产物(19)

mRNA Protein Name
NM_001301861.2 NP_001288790.1 brother of CDO isoform 1 precursor
NM_001301867.2 NP_001288796.1 brother of CDO isoform 3 precursor
NM_001378073.1 NP_001365002.1 brother of CDO isoform 1 precursor
NM_001378074.1 NP_001365003.1 brother of CDO isoform 1 precursor
NM_001378075.1 NP_001365004.1 brother of CDO isoform 2 precursor
NM_001387919.1 NP_001374848.1 brother of CDO isoform 1 precursor
NM_001387920.1 NP_001374849.1 brother of CDO isoform 2 precursor
NM_001387921.1 NP_001374850.1 brother of CDO isoform 2 precursor
NM_001387922.1 NP_001374851.1 brother of CDO isoform 3 precursor
NM_001387923.1 NP_001374852.1 brother of CDO isoform 3 precursor
NM_001387924.1 NP_001374853.1 brother of CDO isoform 4 precursor
NM_001387925.1 NP_001374854.1 brother of CDO isoform 5 precursor
NM_001387926.1 NP_001374855.1 brother of CDO isoform 6 precursor
NM_001387927.1 NP_001374856.1 brother of CDO isoform 7 precursor
NM_001387928.1 NP_001374857.1 brother of CDO isoform 7 precursor
NM_001387929.1 NP_001374858.1 brother of CDO isoform 8 precursor
NM_001387930.1 NP_001374859.1 brother of CDO isoform 8 precursor
NM_001387932.1 NP_001374861.1 brother of CDO isoform 9 precursor
NM_033254.4 NP_150279.1 brother of CDO isoform 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11782431 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

BOC 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (36 - 123)

Ig_2

Ig_2: Immunoglobulin domain (133 - 212)

I-set

I-set: Immunoglobulin I-set domain (238 - 311)

I-set

I-set: Immunoglobulin I-set domain (323 - 406)

fn3

fn3: Fibronectin type III domain (485 - 559)

fn3

fn3: Fibronectin type III domain (608 - 693)

fn3

fn3: Fibronectin type III domain (720 - 802)

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  • 1114 a.a.
蛋白主名 其他名称

brother of CDO

Boc homolog

BOC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
BOC Q9BWV1 Gas1 Mus musculus Q01721
Anti Bait CoIP
21802063
种属间
BOC Q9BWV1 Gas1 Mus musculus Q01721
Pull Down
21802063
种属间
BOC Q9BWV1 Cdon Rattus norvegicus O35158
Anti Bait CoIP
21802063
种属间
BOC Q9BWV1 Cdon Rattus norvegicus O35158
Pull Down
21802063
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 BOC 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7671 BOC Protein, Human (HEK293, His) Q96DN7 (A30-S157) ≥95%

关联疾病

疾病名称 别名
Holoprosencephaly

Holoprosencephaly Sequence

Hpe

Hpe - [Holoprosencephaly]

Acrocapitofemoral Dysplasia

ACFD

Dysplasia, Acrocapitofemoral

Chromosome 10q23 Deletion Syndrome
Pallister-Hall Syndrome

PHS

Hypothalamic Hamartomas

Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly

Hypothalamic Hamartoblastoma Syndrome

Hamartoma Of The Hypothalamus

Pallister Hall Syndrome

Hall-Pallister Syndrome

Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly

Hamartoma, Hypothalamic

Basal Cell Nevus Syndrome

Nevoid Basal Cell Carcinoma Syndrome

Gorlin Syndrome

Nbccs

BCNS

Gorlin-Goltz Syndrome

Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies

Cerebral Gigantism Jaw Cysts

Cramer Niederdellmann Syndrome

Gorlin Syndrome Or Gorlin-Goltz Syndrome

Naevoid Basal Cell Carcinoma Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris BOC VGNC VGNC:38495
Bos taurus BOC VGNC VGNC:26536
Felis catus BOC VGNC VGNC:60145
Mus musculus BOC MGD MGI:2151153
Macaca mulatta BOC VGNC VGNC:70332
Rattus norvegicus BOC RGD RGD:1304550
Others BOC NCBI