2. Immunology/Inflammation Neuronal Signaling
  3. NO Synthase COX Cholinesterase (ChE) Amyloid-β
  4. Neuroprotective agent 5

Neuroprotective agent 5 (compound 28) 是一种脑渗透剂，具有抗神经炎，抗氧化损伤和神经保护作用。Neuroprotective agent 5 表现出强效的 NO 抑制作用 (EC50=0.49 μM)，可抑制促炎因子 PGE2 和 TNF-α 的释放，下调 iNOS 和 COX-2 蛋白的表达，促进 BV-2 细胞由促炎 M1 表型向抗炎 M2 表型极化。此外，Neuroprotective agent 5 还能剂量依赖性地抑制乙酰胆碱酯酶 (AChE) 活性和 Aβ42 的聚集。Neuroprotective agent 5 可用于阿尔兹海默病的研究。

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Neuroprotective agent 5 Chemical Structure

Neuroprotective agent 5 Chemical Structure

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Neuroprotective agent 5 相关抗体

Top Publications Citing Use of Products

查看 NO Synthase 亚型特异性产品:

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nNOS iNOS eNOS

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

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AChE BChE

  • 生物活性

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生物活性

Neuroprotective agent 5 (compound 28) is a brain permeabilizing agent with anti-neuritis, anti-oxidative damage and neuroprotective effects. Neuroprotective agent 5 exhibits a potent NO inhibitory effect (EC50=0.49 μM), inhibits the release of proinflammatory factors PGE2 and TNF-α, downregulates the expression of iNOS and COX-2 proteins, and promotes the polarization of BV-2 cells from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype. In addition, Neuroprotective agent 5 can also inhibit acetylcholinesterase (AChE) activity and Aβ42 aggregation in a dose-dependent manner. Neuroprotective agent 5 can be used for the study of Alzheimer's disease[1].

IC50 & Target

血脑
分子量

291.28

Formula

C14H14FN3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neuroprotective agent 5 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuroprotective agent 5Neuroprotective agent5Neuroprotective agent-5NO SynthaseCOXCholinesterase (ChE)Amyloid-βNitric oxide synthasesNOSCyclooxygenaseβ-amyloid peptideAβAbetaAlzheimer's diseaseoxidative damageneuroprotectionBV-2 cellsproinflammatory factorsInhibitorinhibitorinhibit

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