2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Phrixotoxin 3-NH2 TFA

Phrixotoxin 3-NH2 TFA 是 Phrixotoxin 3 TFA (HY-P1218A) 的衍生物。Phrixotoxin 3 TFA 是一种有效的电压门控钠通道阻滞剂，抑制 NaV1.2，NaV1.3，NaV1.4，NaV1.1 和 NaV1.5，IC50 值分别为 0.6、42、72、288 和 610 nM。Phrixotoxin 3 TFA 通过引起门控动力学的去极化变化并阻止钠电流的内向分量，从而调节电压门控钠通道，使其具有与典型门控修饰剂毒素相似的特性。

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Phrixotoxin 3-NH2 TFA Chemical Structure

Phrixotoxin 3-NH2 TFA Chemical Structure

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规格 价格 是否有货 数量
100 μg ￥3500
In-stock
500 μg 现货 询价

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Other Forms of Phrixotoxin 3-NH2 TFA:

Phrixotoxin 3-NH2 TFA 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Phrixotoxin 3-NH2 TFA is a derivative of Phrixotoxin 3 TFA (HY-P1218A). Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current[1].

分子量

4058.74 (free base)

Formula

C176H270N52O47S6.xC2HF3O2
性状

固体

Sequence

Asp-Cys-Leu-Gly-Phe-Leu-Trp-Lys-Cys-Asn-Pro-Ser-Asn-Asp-Lys-Cys-Cys-Arg-Pro-Asn-Leu-Val-Cys-Ser-Arg-Lys-Asp-Lys-Trp-Cys-Lys-Tyr-Gln-Ile-NH2 (Disulfide bridge:Cys2-Cys17;Cys9-Cys23;Cys16-Cys30)
Sequence Shortening

DCLGFLWKCNPSNDKCCRPNLVCSRKDKWCKYQI-NH2 (Disulfide bridge:Cys2-Cys17;Cys9-Cys23;Cys16-Cys30)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Phrixotoxin 3-NH2 TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phrixotoxin 3-NH2Sodium ChannelNa channelsNa+ channelsvoltage-gatedsodiumchannelsNaV1.1NaV1.2NaV1.3NaV1.4NaV1.5toxinsInhibitorinhibitorinhibit

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产品名称：
Phrixotoxin 3-NH2 TFA
目录号：
HY-P1218B
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