Gentamicin sulfate (Synonyms: 硫酸庆大霉素)

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Data Sheet SDS COA 产品使用指南

摩尔计算器

Gentamicin sulfate 是一种具有口服活性的氨基糖苷类抗生素，抑制革兰氏阳性菌和革兰氏阴性细菌的生长并可抑制组织培养中的多种支原体菌株。Gentamicin sulfate 抑制 DNase I 活性的 IC₅₀ 值为 0.57 mM。

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Gentamicin sulfate Chemical Structure

CAS No. : 1405-41-0

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Other Forms of Gentamicin sulfate:

Gentamicin In-stock
Gentamicin sulfate (Standard) 询价

MCE 顾客使用本产品发表的 32 篇科研文献

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生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

Gentamicin sulfate, an orally active aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin sulfate inhibits DNase I with an IC₅₀ of 0.57 mM^[1]^[2]^[3]^[4].

IC₅₀ & Target

Aminoglycoside

体外研究
(In Vitro)

Gentamicin 是一种比联合青霉素-链霉素更有效的体外细菌抑制剂，对组织培养单层无毒，并且不抑制病毒复制^[2]。
Gentamicin 已成功用作真菌学培养基中的添加剂以抑制细菌的生长，并已被证明对更广泛的生物体具有杀菌作用 (铜绿假单胞菌、变形杆菌属和粪链球菌)，优于青霉素和链霉素^[2]。
Gentamicin 不干扰组织中某些埃可病毒和脊髓灰质炎病毒产生的细胞病变效应培养物，对恒河猴肾脏、HeLa 和人羊膜细胞无毒，并且在高压灭菌温度下稳定^[2]。
Gentamicin 由小单孢菌属的各种物种产生^[3]。
RNA^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Gentamicin sulfate (口服和注射剂型) 在小鼠感染模型中证实对鼠疫耶尔森氏菌具有有效的抗菌活性^[3]。
Gentamicin sulfate (0.27 g/kg) 显示小鼠异物上的细菌显著减少^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

561.65 (Average)

Formula

C₂₄H₅₅N₇O₁₁S^3*

CAS 号

1405-41-0

性状

固体

颜色

White to off-white

中文名称

硫酸庆大霉素；庆大霉素硫酸盐；硫酸艮他霉素；硫酸正泰霉素；硫酸双生霉素；庆大霉素硫酸酯

结构分类

初始来源

微生物

Micromonospora purpurea

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

细胞实验：

H₂O 中的溶解度 : ≥ 30 mg/mL

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

* "≥" means soluble, but saturation unknown.

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL; 澄清溶液; 超声助溶

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测水 / PBS / Saline 中的溶解度数据。

您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。

纯度 & 产品资料

选择批次：

Data Sheet (632 KB) SDS (393 KB)

COA (265 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Xu W, et al. A rapid and sensitive method for kinetic study and activity assay of DNase I in vitro based on a GO-quenched hairpin probe. Anal Bioanal Chem. 2016 May;408(14):3801-9. [Content Brief]

[2]. Rudin A, et al. Antibacterial activity of gentamicin sulfate in tissue culture. Appl Microbiol. 1970 Dec;20(6):989-90. [Content Brief]

[3]. Kumar CG, et al. Microbial biosynthesis and applications of gentamicin: a critical appraisal. [Content Brief]

[4]. Espersen F, et al. Effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreignbody infection. Antimicrob Agents Chemother. 1994 Sep;38(9):2047-53. [Content Brief]

Animal Administration ^[4]	Mice: Bacterial challenged mice are treated with methicillin, gentamicin, both methicillin and gentamicin, or no antibiotics. The treatment is given three times a day for up to 3 days. Each dose of methicillin is 75 mg per mouse (3 g/kg of body weight), and the gentamicin dose is 0.75 mg per mouse (0.03 g/kg). The antibiotics are given subcutaneously in 0.1 or 0.5 mL of saline. Mice are sacrificed and serum and aspirate samples are collected^[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Xu W, et al. A rapid and sensitive method for kinetic study and activity assay of DNase I in vitro based on a GO-quenched hairpin probe. Anal Bioanal Chem. 2016 May;408(14):3801-9. [Content Brief] [2]. Rudin A, et al. Antibacterial activity of gentamicin sulfate in tissue culture. Appl Microbiol. 1970 Dec;20(6):989-90. [Content Brief] [3]. Kumar CG, et al. Microbial biosynthesis and applications of gentamicin: a critical appraisal. [Content Brief] [4]. Espersen F, et al. Effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreignbody infection. Antimicrob Agents Chemother. 1994 Sep;38(9):2047-53. [Content Brief]

Animal Administration
^[4]

Mice: Bacterial challenged mice are treated with methicillin, gentamicin, both methicillin and gentamicin, or no antibiotics. The treatment is given three times a day for up to 3 days. Each dose of methicillin is 75 mg per mouse (3 g/kg of body weight), and the gentamicin dose is 0.75 mg per mouse (0.03 g/kg). The antibiotics are given subcutaneously in 0.1 or 0.5 mL of saline. Mice are sacrificed and serum and aspirate samples are collected^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Xu W, et al. A rapid and sensitive method for kinetic study and activity assay of DNase I in vitro based on a GO-quenched hairpin probe. Anal Bioanal Chem. 2016 May;408(14):3801-9. [Content Brief]

[2]. Rudin A, et al. Antibacterial activity of gentamicin sulfate in tissue culture. Appl Microbiol. 1970 Dec;20(6):989-90. [Content Brief]

[3]. Kumar CG, et al. Microbial biosynthesis and applications of gentamicin: a critical appraisal. [Content Brief]

[4]. Espersen F, et al. Effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreignbody infection. Antimicrob Agents Chemother. 1994 Sep;38(9):2047-53. [Content Brief]

Gentamicin sulfate 相关分类

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gentamicin1405-41-0硫酸庆大霉素庆大霉素硫酸盐硫酸艮他霉素硫酸正泰霉素硫酸双生霉素庆大霉素硫酸酯BacterialAntibioticMeniere’s diseaseglandular tularemiaorally activeInhibitorinhibitorinhibit

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沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Gentamicin sulfate (Synonyms: 硫酸庆大霉素)

Customer Review

Other Forms of Gentamicin sulfate:

MCE 顾客使用本产品发表的 32 篇科研文献