Solamargine (Synonyms: 澳洲茄边碱; Solamargin; δ-Solanigrine)

目录号: HY-N0069 纯度: 99.97%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Solamargine 是一种来源于茄属植物的类固醇 Solasodine 的衍生物，在多种癌症中均表现出抗癌活性。Solamargine 诱导非选择性细胞毒性和 P-gp 抑制作用。Solamargine 通过下调 MMP-2 和 MMP-9 的表达和活性来显着抑制 HepG2 细胞的迁移和侵袭。

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Solamargine Chemical Structure

CAS No. : 20311-51-7

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥1719	In-stock
1 mg	￥548	In-stock
5 mg	￥1200	In-stock
10 mg	￥1800	In-stock
50 mg	现货	询价
100 mg		询价
200 mg		询价

or 大包装询价

* Please select Quantity before adding items.

Customer Review

Other Forms of Solamargine:

Solamargine (Standard) 询价

MCE 顾客使用本产品发表的 11 篇科研文献

: Solamargine purchased from MCE. Usage Cited in: Int J Oncol. 2019 Mar;54(3):905-915. [Abstract]; Western blot analysis for the protein expression of XIAP, survivin, Ki‑67, PCNA and cyclin D1 in the treatment of MOCK, solamargine and Fe_{3_{O₄-solamargine.}}

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生物活性
纯度 & 产品资料
参考文献

生物活性

Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity^[1]^[2].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	8 μM Compound: 1, Solamargine	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 21482107]
A549	IC₅₀	8.18 μM Compound: SM	Cytotoxicity against human A549 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 24534485]
H9c2	IC₅₀	> 20 μM Compound: 1, Solamargine	Cytotoxicity against rat H9c2 cells by MTT assay Cytotoxicity against rat H9c2 cells by MTT assay	[PMID: 21482107]
HCT-116	IC₅₀	3.8 μM Compound: 1, Solamargine	Cytotoxicity against human HCT116 cells by MTT assay Cytotoxicity against human HCT116 cells by MTT assay	[PMID: 21482107]
HeLa	IC₅₀	6 μM Compound: 1, Solamargine	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 21482107]
HepG2	IC₅₀	2.5 μM Compound: 1, Solamargine	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 21482107]
HepG2	IC₅₀	2.67 μM Compound: SM	Cytotoxicity against human HepG2 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 24534485]
K562	IC₅₀	5.2 μM Compound: 1, Solamargine	Cytotoxicity against human K562 cells by MTT assay Cytotoxicity against human K562 cells by MTT assay	[PMID: 21482107]
L02	IC₅₀	13.23 μM Compound: SM	Cytotoxicity against human HL-7702 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human HL-7702 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 24534485]
L02	IC₅₀	13.5 μM Compound: 1, Solamargine	Cytotoxicity against human HL-7702 by MTT assay Cytotoxicity against human HL-7702 by MTT assay	[PMID: 21482107]
MCF7	IC₅₀	2.1 μM Compound: 1, Solamargine	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 21482107]
MCF7	IC₅₀	8.12 μM Compound: SM	Cytotoxicity against human MCF7 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 24534485]
PLC-PRF-5	ED₅₀	1.53 μg/mL Compound: solamargine	Cytotoxicity against human PLC/PRF/5 cells by microassay Cytotoxicity against human PLC/PRF/5 cells by microassay	[PMID: 2380724]
U-87MG ATCC	IC₅₀	3.2 μM Compound: 1, Solamargine	Cytotoxicity against human U87 cells by MTT assay Cytotoxicity against human U87 cells by MTT assay	[PMID: 21482107]

体外研究
(In Vitro)

Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis^[3].
Solamargine (72 hours) dramatically inhibits the proliferation of SMMC-7721 and HepG2 cells in a dose- and time-dependent manner. The IC₅₀s are 9.21 and 19.88 μg/ml, respectively^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:	SMMC-7721cells
Concentration:	15 μg/ml
Incubation Time:	72 hours
Result:	Displayed a significant increase of sub-G1.

体内研究
(In Vivo)

Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC in vivo^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female specific pathogen-free BALB/c nude mice weighing 18-20 g (6-8-weeks-old)^[4]
Dosage:	10 mg/kg
Administration:	Intragastric administration; once daily for 8 days
Result:	Tumor growth was significantly inhibited .

分子量

868.06

Formula

C₄₅H₇₃NO₁₅

CAS 号

20311-51-7

性状

固体

颜色

White to off-white

中文名称

澳洲茄边碱；边缘茄碱

结构分类

Saccharides

Steroids

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : 100 mg/mL (115.20 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.1520 mL	5.7600 mL	11.5199 mL
5 mM	0.2304 mL	1.1520 mL	2.3040 mL
10 mM	0.1152 mL	0.5760 mL	1.1520 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.88 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (2.88 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (2.88 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.97%

选择批次：

Data Sheet (631 KB) SDS (393 KB)

COA (291 KB) HNMR (362 KB) RP-HPLC (213 KB) MS (69 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Burger T, et al. Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum induces non-selective cytotoxicity and P-glycoprotein inhibition. BMC Complement Altern Med. 2018 May 2;18(1):137. [Content Brief]

[2]. Sani IK, et al. Solamargine inhibits migration and invasion of human hepatocellular carcinoma cells through down-regulation of matrix metalloproteinases 2 and 9 expression and activity. Toxicol In Vitro. 2015 Aug;29(5):893-900. [Content Brief]

[3]. Ding X, et al. Induction of apoptosis in human hepatoma SMMC-7721 cells by solamargine from Solanum nigrum L. J Ethnopharmacol. 2012 Jan 31;139(2):599-604. [Content Brief]

[4]. Fu R, et al. Solamargine inhibits gastric cancer progression by regulating the expression of lncNEAT1_2 via the MAPK signaling pathway. Int J Oncol. 2019 May;54(5):1545-1554. [Content Brief]

Solamargine 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1520 mL	5.7600 mL	11.5199 mL	28.7999 mL
	5 mM	0.2304 mL	1.1520 mL	2.3040 mL	5.7600 mL
	10 mM	0.1152 mL	0.5760 mL	1.1520 mL	2.8800 mL
	15 mM	0.0768 mL	0.3840 mL	0.7680 mL	1.9200 mL
	20 mM	0.0576 mL	0.2880 mL	0.5760 mL	1.4400 mL
	25 mM	0.0461 mL	0.2304 mL	0.4608 mL	1.1520 mL
	30 mM	0.0384 mL	0.1920 mL	0.3840 mL	0.9600 mL
	40 mM	0.0288 mL	0.1440 mL	0.2880 mL	0.7200 mL
	50 mM	0.0230 mL	0.1152 mL	0.2304 mL	0.5760 mL
	60 mM	0.0192 mL	0.0960 mL	0.1920 mL	0.4800 mL
	80 mM	0.0144 mL	0.0720 mL	0.1440 mL	0.3600 mL
	100 mM	0.0115 mL	0.0576 mL	0.1152 mL	0.2880 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Solamargine (Synonyms: 澳洲茄边碱; Solamargin; δ-Solanigrine)

Customer Review

Other Forms of Solamargine:

MCE 顾客使用本产品发表的 11 篇科研文献