2. Apoptosis PI3K/Akt/mTOR NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Cell Cycle/DNA Damage Epigenetics
  3. Apoptosis Akt PI3K NF-κB MDM-2/p53 Caspase Reactive Oxygen Species Toll-like Receptor (TLR) PARP
  4. Dracorhodin perchlorate

Dracorhodin perchlorate  (Synonyms: 血竭素高氯酸盐; Dracohodin perochlorate)

目录号: HY-N0726 纯度: 99.14%
COA 产品使用指南 技术支持

Dracorhodin perchlorate (Dracohodin perochlorate) 是一种天然产物。Dracorhodin perchlorate 可以从天然活性分子血竭中得到。Dracorhodin perchlorate 抑制 PI3K/Akt 和 NF-κB 活化，上调 p53 表达，激活 caspase，产生 ROS，促进凋亡 (Apoptosis)。Dracorhodin perchlorate 调节 TLR4。Dracorhodin perchlorate 促进伤口愈合，改善糖尿病。Dracorhodin perchlorate 对前列腺癌、乳腺癌、宫颈癌等癌症具有抗肿瘤活性[sup>[sup>[sup>[sup>[sup>[4][sup>[6]。

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Dracorhodin perchlorate Chemical Structure

Dracorhodin perchlorate Chemical Structure

CAS No. : 125536-25-6

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥565
In-stock
1 mg ￥266
In-stock
5 mg ￥700
In-stock
10 mg ￥1200
In-stock
20 mg ￥2000
In-stock
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Customer Review

Other Forms of Dracorhodin perchlorate:

Dracorhodin perchlorate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dracorhodin perchlorate (Dracohodin perochlorate) is a natural product. Dracorhodin perchlorate can be obtained from the natural active molecule Dragon's blood. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, upregulates p53 expression, activates caspase, produces ROS, and promotes Apoptosis. Dracorhodin perchlorate regulates the TLR4. Dracorhodin perchlorate promotes wound healing, improves diabetes. Dracorhodin perchlorate has anti-tumor activity against prostate cancer, breast cancer, cervical cancer and other cancers[1][2][3][4][5][6][7][8].

IC50 & Target[1][2][3][4][5][6][7][8]

TLR4

 

Caspase 3

 

体外研究
(In Vitro)

Dracorhodin perchlorate (0-80 μM; 12-48 h) 以剂量和时间依赖性方式抑制人宫颈癌 HeLa 细胞、人恶性黑色素瘤 A375-S2 细胞、人乳腺癌 MCF-7 细胞和人组织细胞淋巴瘤 U937 细胞的生长[1]。
Dracorhodin perchlorate (0-200 μM; 48 h) 以剂量依赖性方式抑制人胃腺癌 SGC-7901 细胞的生长[2]。
Dracorhodin perchlorate (0.625-40 μg/mL; 24 h) 在浓度为 0.625-10 μg/mL 时促进 NIH/3T3 成纤维细胞增殖，在浓度 >20 μg/mL 时抑制增殖[3]。
Dracorhodin perchlorate (10-80 μM；12-48 h) 以剂量和时间依赖性方式抑制人前列腺癌 PC-3 细胞的生长，24 h 时的 IC50为 40.18 μM[4]。
Dracorhodin perchlorate (40-150 μM；12-48 h) 以剂量和时间依赖性方式抑制 MCF-7 细胞的生长[5]。
Dracorhodin perchlorate (10 μg/mL；3-9 h) 上调 INS-1 细胞中的 Pdx1 表达[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dracorhodin perchlorate 相关抗体:

Apoptosis Analysis[2]

Cell Line: SGC-7901
Concentration: 60, 80, 100 μM
Incubation Time: 48 h
Result: Induced G1/S or G1 phase arrest and apoptosis, as shown by changes in cell cycle distribution, nuclear morphology, and apoptotic markers.
Regulated the expression of proteins involved in cell cycle and apoptosis pathways, such as p53, p21 waf1, Bcl-2 family proteins, and phosphorylated Akt and PI3K.
Affected caspase-3 activation, leading to PARP cleavage.
体内研究
(In Vivo)

Dracorhodin perchlorate (2.5-10 μg/mL；以软膏形式涂抹；每日两次；0-14 天) 可促进大鼠伤口愈合，表现为伤口愈合率增加、伤口组织成纤维细胞增殖增强、伤口组织磷酸化 ERK 上调[3]。
Dracorhodin perchlorate (200 μg/mL；局部应用) 通过调节 TLR4 通路和相关炎症因子促进糖尿病大鼠皮肤伤口愈合、胶原沉积和微血管形成[6]。
Dracorhodin perchlorate (5-20 mg/kg；腹腔注射；隔天；30 天) 可降低血糖、升高胰岛素水平、增强 Pdx1 表达、增加胰岛大小和数量，并对糖尿病小鼠的胰岛和 β 细胞具有保护作用[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (170-220 g, clean grade, 7-week-old approximately)+diabetes mellitus model induced by Streptozotocin (HY-13753) injection and high-fat diet[6]
Dosage: 200 μg/mL (dissolved in DMSO and made into ointment with Vaseline)
Administration: Topical application
Result: Accelerated the wound healing in diabetic rats.
Increased the wound healing rate.
Promoted collagen deposition and inhibited scar formation.
Increased the number of microvessels.
Reduced the activation of the TLR4 pathway, decreased the mRNA and protein expressions of inflammatory factors, increased eNOS protein expression and NO content in the later stage of wound healing.
分子量

366.75

Formula

C17H15ClO7
CAS 号
性状

固体

颜色

Yellow to orange

中文名称

血竭素高氯酸盐
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (272.67 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7267 mL 13.6333 mL 27.2665 mL
5 mM 0.5453 mL 2.7267 mL 5.4533 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.14%

COA (285 KB) HNMR (267 KB) RP-HPLC (257 KB) MS (188 KB)

产品使用指南 (1538 KB)
参考文献

Dracorhodin perchlorate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7267 mL 13.6333 mL 27.2665 mL 68.1663 mL
5 mM 0.5453 mL 2.7267 mL 5.4533 mL 13.6333 mL
10 mM 0.2727 mL 1.3633 mL 2.7267 mL 6.8166 mL
15 mM 0.1818 mL 0.9089 mL 1.8178 mL 4.5444 mL
20 mM 0.1363 mL 0.6817 mL 1.3633 mL 3.4083 mL
25 mM 0.1091 mL 0.5453 mL 1.0907 mL 2.7267 mL
30 mM 0.0909 mL 0.4544 mL 0.9089 mL 2.2722 mL
40 mM 0.0682 mL 0.3408 mL 0.6817 mL 1.7042 mL
50 mM 0.0545 mL 0.2727 mL 0.5453 mL 1.3633 mL
60 mM 0.0454 mL 0.2272 mL 0.4544 mL 1.1361 mL
80 mM 0.0341 mL 0.1704 mL 0.3408 mL 0.8521 mL
100 mM 0.0273 mL 0.1363 mL 0.2727 mL 0.6817 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dracorhodin125536-25-6Dracohodin perochlorate血竭素高氯酸盐ApoptosisAktPI3KNF-κBMDM-2/p53CaspaseReactive Oxygen SpeciesToll-like Receptor (TLR)PARPPKBProtein kinase BPhosphoinositide 3-kinaseNuclear factor-κBNuclear factor-kappaBpoly ADP ribose polymerasePC-3MCF-7INS-1 SGC-7901 HeLadiabeticwound healingPro-apoptoticInhibitorinhibitorinhibit

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