2. Gene
  3. Bdnf - brain derived neurotrophic factor Gene

Bdnf - brain derived neurotrophic factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 12064 | 基因类型: protein coding

关于 Bdnf

功能概要

The protein encoded by this gene is a member of the nerve growth factor family. It is involved in the growth, differentiation and survival of specific types of developing neurons both in the central nervous system (CNS) and the peripheral nervous system. It is also involved in regulating synaptic plasticity in the CNS. Expression of a similar gene in human is reduced in both Alzheimer's and Huntington disease patients. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]

Bdnf 基因产物(12)

mRNA Protein Name
NM_001048139.1 NP_001041604.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001048141.1 NP_001041606.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001048142.1 NP_001041607.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285416.1 NP_001272345.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285417.1 NP_001272346.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285418.1 NP_001272347.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285419.1 NP_001272348.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285420.1 NP_001272349.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285421.1 NP_001272350.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285422.1 NP_001272351.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_001316310.1 NP_001303239.1 brain-derived neurotrophic factor isoform 2 preproprotein
NM_007540.4 NP_031566.4 brain-derived neurotrophic factor isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11684666 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within axon extension IDA
IDA: 通过直接分析推断
24035762 MGI
acts upstream of or within axon guidance IMP
IMP: 通过突变表型推断
15014133 MGI
acts upstream of or within axon target recognition IMP
IMP: 通过突变表型推断
15464571 MGI
acts upstream of or within behavioral fear response IMP
IMP: 通过突变表型推断
15249684 MGI
acts upstream of or within cellular response to acid chemical IDA
IDA: 通过直接分析推断
25542970 MGI
involved in circadian rhythm IEP
IEP: 通过表达模式推断
23785138 MGI
acts upstream of or within dendrite development IMP
IMP: 通过突变表型推断
12890780 MGI
acts upstream of or within dendrite extension IDA
IDA: 通过直接分析推断
24035762 MGI
acts upstream of or within fear response IMP
IMP: 通过突变表型推断
15249684 MGI
acts upstream of or within feeding behavior IMP
IMP: 通过突变表型推断
12796784 MGI
acts upstream of or within gamma-aminobutyric acid signaling pathway IDA
IDA: 通过直接分析推断
16754670 MGI
acts upstream of or within glutamate secretion IPI
IPI: 通过物理相互作用推断
16819522 MGI
acts upstream of or within inhibitory postsynaptic potential IMP
IMP: 通过突变表型推断
24201284 MGI
acts upstream of or within inner ear development IMP
IMP: 通过突变表型推断
7605630 MGI
acts upstream of or within learning or memory IMP
IMP: 通过突变表型推断
15249684 MGI
acts upstream of or within mechanoreceptor differentiation IGI
IGI: 通过遗传相互作用推断
15376326 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
12904469 MGI
involved in negative regulation of apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
26708520 MGI
acts upstream of or within negative regulation of neuroblast proliferation IDA
IDA: 通过直接分析推断
12798291 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
8861722 MGI
acts upstream of or within negative regulation of programmed cell death IMP
IMP: 通过突变表型推断
24378336 MGI
acts upstream of or within negative regulation of synaptic transmission, GABAergic IDA
IDA: 通过直接分析推断
16754670 MGI
acts upstream of or within nerve development IMP
IMP: 通过突变表型推断
7605630 MGI
acts upstream of neuron apoptotic process IMP
IMP: 通过突变表型推断
8861722 MGI
acts upstream of or within neuron recognition IMP
IMP: 通过突变表型推断
15844198 MGI
acts upstream of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
23878391 MGI
NOT acts upstream of or within positive regulation of axon extension IMP
IMP: 通过突变表型推断
24573299 MGI
acts upstream of or within positive regulation of collateral sprouting IDA
IDA: 通过直接分析推断
24573299 MGI
acts upstream of or within positive regulation of collateral sprouting IMP
IMP: 通过突变表型推断
24573299 MGI
acts upstream of or within positive regulation of neuron differentiation IDA
IDA: 通过直接分析推断
12798291 MGI
involved in positive regulation of neuron projection development IGI
IGI: 通过遗传相互作用推断
26708520 MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
23878391 MGI
acts upstream of or within regulation of collateral sprouting IGI
IGI: 通过遗传相互作用推断
24573299 MGI
acts upstream of or within regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
16516892 MGI
acts upstream of or within regulation of retinal cell programmed cell death IDA
IDA: 通过直接分析推断
11747369 MGI
acts upstream of or within regulation of synaptic plasticity IDA
IDA: 通过直接分析推断
16819522 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
15249684 MGI
acts upstream of or within taste bud development IMP
IMP: 通过突变表型推断
24378336 MGI
involved in trans-synaptic signaling by BDNF, modulating synaptic transmission EXP
EXP: 通过实验结果推断
19448629 MGI
involved in trans-synaptic signaling by BDNF, modulating synaptic transmission IDA
IDA: 通过直接分析推断
19448629 MGI
acts upstream of or within ureteric bud development IDA
IDA: 通过直接分析推断
16018995 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
19448629 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
22209827 MGI
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
14715936 MGI
located in dendrite IDA
IDA: 通过直接分析推断
19448629 MGI
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
19448629 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
19448629 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: 通过直接分析推断
22412021 MGI
is active in neuronal dense core vesicle IDA
IDA: 通过直接分析推断
22412021 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
22209827 MGI
located in secretory granule IDA
IDA: 通过直接分析推断
24573299 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

brain-derived neurotrophic factor

重组 Bdnf 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74383 BDNF Protein, Mouse (R129A, R130A, HEK293, His, Solution) P21237-1 (A19-R249, R129A, R130A) ≥95%

相关产品

Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-B1618 Corticosterone Agonist 99.76% Phase 3
HY-114384B NV-5138 hydrochloride Activator ≥98.0% Phase 2
HY-139897 CX 717 Agonist 99.79% Phase 2
HY-120251A Leteprinim potassium Inhibitor ≥99.0% Phase 2
Pre-clinical Phase
生物活性分子 (37)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W013372 7,8-Dihydroxyflavone 99.90% 否
HY-106224B Orexin A (human, rat, mouse) (acetate) Agonist 99.93% 否
HY-P1178 Cyclotraxin B Inhibitor 98.11% 否
HY-100115 TA-02 Inhibitor 99.85% 否
HY-N2055 Kaempferol 3-O-sophoroside 99.84% 否
HY-N2038 3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone Inhibitor 99.85% 否
HY-N7981 Pratensein Inhibitor 99.92% 否
HY-110166 PD 90780 Antagonist ≥99.0% 否
HY-N6076 Tenuifoliside A Inhibitor 98.07% 否
HY-RS16220 Bdnf Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-153383 PDCD4-IN-1 99.65% 否
HY-N3298 Meranzin Modulator ≥98.0% 否
HY-124591 TC-2153 Inhibitor 98.73% 否
HY-132993 Hcyb1 Inhibitor 98.24% 否
HY-W044525 Phyllodulcin Inhibitor 98.15% 否
HY-102091 (2R,4R)-APDC Agonist / 否
HY-102091A (2R,4R)-APDC hydrate Agonist ≥98.0% 否
HY-122742 HBT1 99.83% 否
HY-160921 Capeserod Agonist 98.66% 否
HY-120251 Leteprinim Inhibitor / 否
HY-120306 HHL-6 / 否
HY-121012 (rac)-AG-205 / 否
HY-123222 CGP 56999 Antagonist / 否
HY-123439 FTY720-C2 / 否
HY-146523 TRK-IN-17 Inhibitor / 否
HY-146524 TRK-IN-18 Inhibitor / 否
HY-157792 Antidepressant agent 6 Antagonist / 否
HY-N11872 Suffruticosol A Activator / 否
HY-N4161 Euparin Inhibitor ≥99.0% 否
HY-P1178A Cyclotraxin B TFA Inhibitor / 否
HY-RS01460 BDNF Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-111527 PPZ2 / 否
HY-124503 Longanlactone Activator / 否
HY-139806 SRA880 free base / 否
HY-164461 AZD6918 Inhibitor / 否
HY-167836 BNN-20 Activator / 否
HY-W101298S (Leu-13C6,15N)-Ile-OH TFA / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bdnf NCBI NCBI:627
Canis familiaris Bdnf NCBI NCBI:403461
Rattus norvegicus Bdnf NCBI NCBI:24225
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