2. Gene
  3. Egf - epidermal growth factor Gene

Egf - epidermal growth factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 13645 | 基因类型: protein coding

关于 Egf

功能概要

This gene encodes epidermal growth factor (EGF), the founding member of the EGF family of growth factors that are implicated in cell proliferation and differentiation. The encoded protein can localize to the membrane and function in juxtacrine signaling or undergo proteolytic processing to generate a soluble form of the hormone. Mice lacking the encoded protein do not exhibit an abnormal phenotype but transgenic mice overexpressing the encoded protein exhibit hypospermatogenesis. [provided by RefSeq, Jul 2016]

Egf 基因产物(3)

mRNA Protein Name
NM_001310737.1 NP_001297666.1 pro-epidermal growth factor isoform 2
NM_001329594.1 NP_001316523.1 pro-epidermal growth factor isoform 3
NM_010113.4 NP_034243.2 pro-epidermal growth factor isoform 1 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables epidermal growth factor receptor binding IDA
IDA: 通过直接分析推断
6315706 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17626015 MGI
enables receptor ligand activity IDA
IDA: 通过直接分析推断
6248866 MGI
enables transmembrane receptor protein tyrosine kinase activator activity IDA
IDA: 通过直接分析推断
6248866 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERBB2-EGFR signaling pathway IDA
IDA: 通过直接分析推断
22822073 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IDA
IDA: 通过直接分析推断
15831470 MGI
acts upstream of cell population proliferation IGI
IGI: 通过遗传相互作用推断
15509736 MGI
acts upstream of cerebellar granule cell precursor proliferation IDA
IDA: 通过直接分析推断
10027293 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
6315706 MGI
involved in epidermal growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
6248866 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
7641815 MGI
acts upstream of epithelial cell proliferation IGI
IGI: 通过遗传相互作用推断
15509736 MGI
acts upstream of or within mammary gland alveolus development IGI
IGI: 通过遗传相互作用推断
10331984 MGI
involved in negative regulation of cholesterol efflux IDA
IDA: 通过直接分析推断
20037141 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
14561752 MGI
involved in positive regulation of DNA binding IDA
IDA: 通过直接分析推断
15156153 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
9030684 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
8702723 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
7641815 MGI
acts upstream of or within positive regulation of cerebellar granule cell precursor proliferation IDA
IDA: 通过直接分析推断
10027293 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IGI
IGI: 通过遗传相互作用推断
15509736 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
21186272 MGI
acts upstream of or within positive regulation of protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
7678348 MGI
involved in positive regulation of ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
20208556 MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
11940581 MGI
involved in regulation of receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
15156153 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in extracellular space IDA
IDA: 通过直接分析推断
6248866 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
7641815 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
17626015 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

pro-epidermal growth factor

Pro-epidermal growth factor precursor (EGF)

重组 Egf 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7067 EGF Protein, Mouse P01132 (N977-R1029) ≥95%
HY-P70590 EGF Protein, Mouse (His) P01132 (N977-R1029) ≥95%
HY-P72983 EGF Protein, Mouse (HEK293) P01132 (N977-R1029) ≥95%
HY-P72984 EGF Protein, Mouse (P.pastoris) P01132 (N977-R1029) ≥95%
HY-P72985 EGF Protein, Mouse (HEK293, Fc) P01132 (N977-R1029) ≥95%
HY-P70590AF Animal-Free EGF Protein, Mouse (His) P01132 (N977-R1029) ≥95%

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-50895 Gefitinib 99.94% 是
HY-50895A Gefitinib hydrochloride Inhibitor 99.85% 是
HY-50895R Gefitinib (Standard) / 否
HY-50895B Gefitinib dihydrochloride / 否
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99041 Panitumumab Inhibitor 98.80% 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-12872 Nazartinib Inhibitor 99.03% Phase 2
HY-N6674 Diazepinomicin 98.04% Phase 2
HY-12872A Nazartinib mesylate Inhibitor / Phase 2
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99041A Panitumumab (anti-EGFR) Inhibitor 98.00% Phase 4
HY-P99155 Zalutumumab 98.26% Phase 3
Pre-clinical Phase
生物活性分子 (48)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18723 Yoda 1 99.98% 否
HY-13595 Chrysophanol Inhibitor 99.77% 否
HY-145967 FT709 Inhibitor 99.81% 否
HY-104064 1A-116 99.79% 否
HY-19713 LJI308 Inhibitor 99.07% 否
HY-101957 AG 1295 Inhibitor 99.90% 否
HY-13896 PD168393 98.58% 否
HY-16160 Cysmethynil 99.87% 否
HY-101219 VEGFR-IN-1 Inhibitor 98.42% 否
HY-103440 EGFR/ErbB-2/ErbB-4 inhibitor-3 Inhibitor 98.19% 否
HY-P0320 EGF Receptor Substrate 2 (Phospho-Tyr5) 99.90% 否
HY-101042 AG-494 Inhibitor 99.31% 否
HY-124674A CCT365623 hydrochloride 98.07% 否
HY-101429 RG13022 Inhibitor 96.74% 否
HY-101960A Tyrphostin A51 Inhibitor ≥99.0% 否
HY-112345 PD-089828 Inhibitor 98.07% 否
HY-132126 SPHINX Inhibitor 99.87% 否
HY-100923 H-9 Dihydrochloride Inhibitor 98.98% 否
HY-116111 AG 370 Inhibitor ≥97.0% 否
HY-12872B Nazartinib S-enantiomer 98.66% 否
HY-50895S1 Gefitinib-d6 ≥98.0% 否
HY-E70229 Cyclooxygenase 1, sheep / 否
HY-P0320B EGF Receptor Substrate 2 (Phospho-Tyr5) (acetate) 99.00% 否
HY-P1985A Notch 1 TFA 95.03% 否
HY-P2673 Lys-Arg-Thr-Leu-Arg-Arg / 否
HY-101756 SDZ281-977 98.00% 否
HY-100663 Gefitinib impurity 2 99.56% 否
HY-101960 (Z)-Tyrphostin A51 Inhibitor / 否
HY-108931 AG 1406 Inhibitor 99.03% 否
HY-118175 RG 14921 / 否
HY-122564 Pyrimidyn 7 Inhibitor / 否
HY-124152 3,4-Dephostatin Inhibitor / 否
HY-129510 4-Methyl erlotinib Inhibitor / 否
HY-131257 Gefitinib impurity 1 99.59% 否
HY-133779 Gefitinib impurity 5 97.43% 否
HY-13595R Chrysophanol (Standard) Inhibitor / 否
HY-147279 Milpocitide / 否
HY-149352 DG1 Inhibitor / 否
HY-149517 EGFR/BRAFV600E-IN-2 Inhibitor / 否
HY-150687 ZINC12409120 Inhibitor / 否
HY-N3634 Corylifol C / 否
HY-P0320A EGF Receptor Substrate 2 (Phospho-Tyr5) (TFA) / 否
HY-P3918 EGF-R (661-681) T669 Peptide / 否
HY-RS04204 EGF Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-114667 Lavendustin C6 Inhibitor / 否
HY-117523 (Z)-RG-13022 Inhibitor / 否
HY-120857 BPIQ-II hydrochloride / 否
HY-50895S2 Gefitinib-d3 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Egf NCBI NCBI:1950
Canis familiaris Egf NCBI NCBI:403657
Macaca fascicularis Egf NCBI NCBI:102123415
Susscrofa domestica Egf NCBI
Leporidae Egf NCBI
Rattus norvegicus Egf NCBI NCBI:25313
Macaca mulatta Egf NCBI NCBI:698619
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