2. Gene
  3. EGF - Egf epidermal growth factor Gene

EGF - Egf epidermal growth factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 25313 | 基因类型: protein coding

关于 EGF

功能概要

Enables epidermal growth factor receptor binding activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; and positive regulation of fibroblast proliferation. Acts upstream of or within regulation of protein transport. Located in extracellular space. Used to study perinatal necrotizing enterocolitis. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system Cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor). [provided by Alliance of Genome Resources, Apr 2022]

EGF 基因产物(1)

mRNA Protein Name
NM_012842.2 NP_036974.2 pro-epidermal growth factor precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables epidermal growth factor receptor binding IDA
IDA: 通过直接分析推断
2260661 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in epidermal growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
2260661 RGD
involved in kidney development IEP
IEP: 通过表达模式推断
1570198 RGD
involved in positive regulation of DNA biosynthetic process IDA
IDA: 通过直接分析推断
3093142 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
17310240 RGD
involved in positive regulation of fibroblast proliferation IDA
IDA: 通过直接分析推断
3093142 RGD
acts upstream of or within regulation of protein transport IDA
IDA: 通过直接分析推断
19723622 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
3257897 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

pro-epidermal growth factor

重组 EGF 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7092 EGF Protein, Rat P07522/NP_036974.1 (N974-R1026) ≥95%
HY-P7092A EGF Protein, Rat (CHO) P07522 (N974-R1026) ≥95%
HY-P7092Y EGF Protein, Rat (Tag Free, Solution) P07522 (N974-R1026) ≥95%

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-50895 Gefitinib 99.94% 是
HY-50895A Gefitinib hydrochloride Inhibitor 99.85% 是
HY-50895R Gefitinib (Standard) / 否
HY-50895B Gefitinib dihydrochloride / 否
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99041 Panitumumab Inhibitor 98.80% 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-12872 Nazartinib Inhibitor 99.03% Phase 2
HY-N6674 Diazepinomicin 98.04% Phase 2
HY-12872A Nazartinib mesylate Inhibitor / Phase 2
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99041A Panitumumab (anti-EGFR) Inhibitor 98.00% Phase 4
HY-P99155 Zalutumumab 98.26% Phase 3
Pre-clinical Phase
生物活性分子 (51)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18723 Yoda 1 99.98% 否
HY-13595 Chrysophanol Inhibitor 99.77% 否
HY-145967 FT709 Inhibitor 99.81% 否
HY-104064 1A-116 99.79% 否
HY-19713 LJI308 Inhibitor 99.07% 否
HY-101957 AG 1295 Inhibitor 99.90% 否
HY-13896 PD168393 98.58% 否
HY-16160 Cysmethynil 99.87% 否
HY-101219 VEGFR-IN-1 Inhibitor 98.42% 否
HY-103440 EGFR/ErbB-2/ErbB-4 inhibitor-3 Inhibitor 98.19% 否
HY-P0320 EGF Receptor Substrate 2 (Phospho-Tyr5) 99.90% 否
HY-124674A CCT365623 hydrochloride 98.07% 否
HY-101042 AG-494 Inhibitor 99.31% 否
HY-101960A Tyrphostin A51 Inhibitor ≥99.0% 否
HY-112345 PD-089828 Inhibitor 98.07% 否
HY-132126 SPHINX Inhibitor 99.87% 否
HY-100923 H-9 Dihydrochloride Inhibitor 98.98% 否
HY-101429 RG13022 Inhibitor 96.74% 否
HY-116111 AG 370 Inhibitor ≥97.0% 否
HY-12872B Nazartinib S-enantiomer 98.66% 否
HY-50895S1 Gefitinib-d6 ≥98.0% 否
HY-E70229 Cyclooxygenase 1, sheep / 否
HY-P0320B EGF Receptor Substrate 2 (Phospho-Tyr5) (acetate) 99.00% 否
HY-P1985A Notch 1 TFA 95.03% 否
HY-P2673 Lys-Arg-Thr-Leu-Arg-Arg / 否
HY-P2673A Lys-Arg-Thr-Leu-Arg-Arg acetate / 否
HY-101756 SDZ281-977 98.00% 否
HY-100663 Gefitinib impurity 2 99.56% 否
HY-101960 (Z)-Tyrphostin A51 Inhibitor / 否
HY-108931 AG 1406 Inhibitor 99.03% 否
HY-118175 RG 14921 Inhibitor / 否
HY-122564 Pyrimidyn 7 Inhibitor / 否
HY-124152 3,4-Dephostatin Inhibitor / 否
HY-129510 4-Methyl erlotinib Inhibitor / 否
HY-131257 Gefitinib impurity 1 99.59% 否
HY-133779 Gefitinib impurity 5 97.43% 否
HY-13595R Chrysophanol (Standard) Inhibitor / 否
HY-147279 Milpocitide / 否
HY-149352 DG1 Inhibitor / 否
HY-149517 EGFR/BRAFV600E-IN-2 Inhibitor / 否
HY-150687 ZINC12409120 Inhibitor / 否
HY-N3634 Corylifol C / 否
HY-P0320A EGF Receptor Substrate 2 (Phospho-Tyr5) (TFA) / 否
HY-P10301 CXCL9(74-103) / 否
HY-P10697 VH4127 Modulator / 否
HY-P3918 EGF-R (661-681) T669 Peptide / 否
HY-RS04204 EGF Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-114667 Lavendustin C6 Inhibitor / 否
HY-117523 (Z)-RG-13022 Inhibitor / 否
HY-120857 BPIQ-II hydrochloride / 否
HY-50895S2 Gefitinib-d3 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens EGF NCBI NCBI:1950
Canis familiaris EGF NCBI NCBI:403657
Macaca fascicularis EGF NCBI NCBI:102123415
Mus musculus EGF NCBI NCBI:13645
Susscrofa domestica EGF NCBI
Leporidae EGF NCBI
Macaca mulatta EGF NCBI NCBI:698619
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