2. Gene
  3. MAPRE3 - microtubule associated protein RP/EB family member 3 Gene

MAPRE3 - microtubule associated protein RP/EB family member 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：微管相关蛋白 RP/EB 家族成员 3

种属: Homo sapiens

同用名: EB3; RP3; EBF3; EBF3-S

基因 ID: 22924 | 基因类型: protein coding

关于 MAPRE3

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,970,637-27,027,219 (from NCBI)

This gene has 10 transcripts (splice variants), 279 orthologues and 2 paralogues. Broad expression in brain (RPKM 45.3), testis (RPKM 13.7) and 20 other tissues.

功能概要

该基因编码的蛋白质是 RP/EB 基因家族的成员。该蛋白质定位于细胞质微管网络并结合 APCL，这是腺瘤性息肉病大肠杆菌肿瘤抑制基因的同系物。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]

MAPRE3 基因产物(3)

mRNA Protein Name
NM_001303050.2 NP_001289979.1 microtubule-associated protein RP/EB family member 3 isoform 1
NM_001410716.1 NP_001397645.1 microtubule-associated protein RP/EB family member 3 isoform 2
NM_012326.4 NP_036458.2 microtubule-associated protein RP/EB family member 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
27107012 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10644998 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
26323690 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of protein kinase activity IDA
IDA: 通过直接分析推断
26323690 GOA
involved in regulation of microtubule polymerization IMP
IMP: 通过突变表型推断
23159740 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with cytoplasmic microtubule IDA
IDA: 通过直接分析推断
10644998 GOA
located in microtubule cytoskeleton IDA
IDA: 通过直接分析推断
10644998 GOA
located in mitotic spindle astral microtubule end IDA
IDA: 通过直接分析推断
23509069 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
10644998 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAPRE3 蛋白结构

CH

CH: Calponin homology (CH) domain (18 - 115)

EB1

EB1: EB1-like C-terminal motif (218 - 257)

  • 0
  • 100
  • 200
  • 281 a.a.
蛋白主名 其他名称

microtubule-associated protein RP/EB family member 3

APC binding protein

重组 MAPRE3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75275 EB3/MAPRE3 Protein, Human (His) Q9UPY8-1 (M1-Y281) ≥95%

关联疾病

疾病名称 别名
Distal Hereditary Motor Neuronopathy Type 7

Dhmn7

Dhmnvpy

Distal Spinal Muscular Atrophy With Vocal Cord Paralysis
Neuronopathy, Distal Hereditary Motor, Type Viib

HMN7B

Hmn Viib

Dhmn7b

Neuropathy, Distal Hereditary Motor, Type Viib

Distal Hereditary Motor Neuronopathy Type 7b

Distal Hereditary Motor Neuropathy Type Viib

Neuronopathy, Distal Hereditary Motor, Type 7b

Neuropathy, Distal Hereditary Motor, With Vocal Cord Paralysis, Type Viib

Lower Motor Neuron Disease, Dynactin Type

Distal Spinal Muscular Atrophy With Vocal Cord Paralysis Type 7b

Harper-Young Myopathy

Neuronopathy, Distal Hereditary Motor, 7b

Distal Hereditary Motor Neuropathy With Vocal Cord Paralysis Type Viib

Lower Motor Neuron Disease Dynactin Type

Plmnd

Progressive Lower Motor Neuron Disease

Neuropathy, Motor, Distal, Hereditary, Type Viib
Marburg Hemorrhagic Fever

Marburg Virus Disease

Marburg Disease

Green Monkey Disease

Mhf

Vervet Monkey Disease

Mard - [Marburg Disease]

Mvd - [Marburg Virus Disease]

Marburg Haemorrhagic Fever

Mhf - [Marburg Haemorrhagic Fever]
Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ebola

Ehf

Ebola Fever

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified
Arthrogryposis, Distal, Type 4

Distal Arthrogryposis Type 4

DA4

Daiid

Arthrogryposis-Severe Scoliosis Syndrome

Distal Arthrogryposis Type Iid

Arthrogryposis With Severe Scoliosis

Arthrogryposis, Distal, Type Iid
Bolivian Hemorrhagic Fever

Machupo Hemorrhagic Fever

Hemorrhagic Fever, Bolivian

Bhf - [Bolivian Haemorrhagic Fever]

Machupo Haemorrhagic Fever
Omsk Hemorrhagic Fever

Ohf

Hemorrhagic Fever, Omsk

Ohf - [Omsk Haemorrhagic Fever]

Spring-Fall Haemorrhagic Fever
Nipah Virus Encephalitis

Equine Morbillivirus
Perry Syndrome

Parkinsonism With Alveolar Hypoventilation And Mental Depression

PERRYS
Helsmoortel-Van Der Aa Syndrome

HVDAS

Mrd28

Adnp Syndrome

Adnp-Related Syndromic Intellectual Disability-Autism Spectrum Disorder

Mental Retardation, Autosomal Dominant 28

Adnp-Related Multiple Congenital Anomalies - Intellectual Disability - Autism Spectrum Disorder

Mental Retardation, Autosomal Dominant 28, Formerly

Mrd28, Formerly

Autosomal Dominant Mental Retardation 28

Adnp-Related Intellectual Disability And Autism Spectrum Disorder

Adnp-Related Multiple Congenital Anomalies-Intellectual Disability-Autism Spectrum Disorder
Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of Extraocular Muscles

Cfeom

Feom

Congenital External Ophthalmoplegia

Congenital Fibrosis Syndrome

General Fibrosis Syndrome
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08139 MAPRE3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MAPRE3 VGNC VGNC:31234
Macaca mulatta MAPRE3 VGNC VGNC:74657
Felis catus MAPRE3 VGNC VGNC:68181
Mus musculus MAPRE3 MGD MGI:2140967
Rattus norvegicus MAPRE3 RGD RGD:1359297
Canis familiaris MAPRE3 VGNC VGNC:43011
Others MAPRE3 NCBI
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