Smo - smoothened, frizzled class receptor Gene

中文名称：光滑的，卷曲的类受体

种属: Mus musculus

同用名: bnb; Smoh; smoothened; E130215L21Rik

关于 Smo

功能概要

预计该基因编码的蛋白可启动修补绑定活动。参与多个过程，包括动物器官发育；调节动物器官形态发生；和基因表达的调控。作用于多个过程的上游或内部，包括动物器官发育；细胞群增殖的正向调节；和区域化。位于 9+0 非运动纤毛中；睫状膜;和细胞质。以多种结构表达，包括第 1 鳃弓； 4细胞期胚胎；消化系统；中枢神经系统;和泌尿生殖系统。用于研究髓母细胞瘤和肺气肿。该基因的人类直系同源物与基底细胞癌有关；肝细胞癌；胰腺癌;和胰腺导管癌。与人类 SMO（平滑的卷曲类受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable patched binding activity. Involved in several processes, including animal organ development; regulation of animal organ morphogenesis; and regulation of gene expression. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regionalization. Located in 9+0 non-motile cilium; ciliary membrane; and cytoplasm. Is expressed in several structures, including 1st branchial arch; 4-cell stage embryo; alimentary system; central nervous system; and genitourinary system. Used to study medulloblastoma and pulmonary emphysema. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human Smo (smoothened, Frizzled class receptor). [provided by Alliance of Genome Resources, Apr 2022]