2. Gene
  3. KPNB1 - karyopherin subunit beta 1 Gene

KPNB1 - karyopherin subunit beta 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：karyopherin 亚基β1

种属: Homo sapiens

同用名: IMB1; IPO1; IPOB; Impnb; NTF97

基因 ID: 3837 | 基因类型: protein coding

关于 KPNB1

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,649,919-47,685,505 (from NCBI)

This gene has 16 transcripts (splice variants), 215 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 74.8), appendix (RPKM 47.4) and 25 other tissues.

功能概要

核质运输是一种信号和能量依赖性过程，通过嵌入核膜中的核孔复合物发生。含有核定位信号 (NLS) 的蛋白质的输入需要 NLS 输入受体，即输入蛋白 alpha 和 beta 亚基的异二聚体，也称为 karyopherins。 Importin alpha 结合细胞质中含有 NLS 的货物，importin beta 将复合物停靠在核孔复合物的细胞质侧。在三磷酸核苷和小 GTP 结合蛋白 Ran 的存在下，复合物进入核孔复合物，输入蛋白亚基解离。 Importin alpha 与其乘客蛋白一起进入核质，而 importin beta 保留在孔隙中。 importin beta 和核孔蛋白的 FG 重复之间的相互作用对于通过孔复合物的易位至关重要。该基因编码的蛋白质是 importin beta 家族的成员。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2013 年 2 月]

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

KPNB1 基因产物(2)

mRNA Protein Name
NM_001276453.2 NP_001263382.1 importin subunit beta-1 isoform 2
NM_002265.6 NP_002256.2 importin subunit beta-1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
22701565 GOA
enables nuclear import signal receptor activity IDA
IDA: 通过直接分析推断
14645851 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9405152 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
11984006 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in NLS-bearing protein import into nucleus IDA
IDA: 通过直接分析推断
14645851 GOA
involved in RNA import into nucleus IDA
IDA: 通过直接分析推断
9670026 GOA
involved in astral microtubule organization IMP
IMP: 通过突变表型推断
23783028 GOA
involved in establishment of mitotic spindle localization IMP
IMP: 通过突变表型推断
23783028 GOA
involved in mitotic chromosome movement towards spindle pole IMP
IMP: 通过突变表型推断
23783028 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: 通过突变表型推断
23783028 GOA
involved in mitotic spindle assembly IMP
IMP: 通过突变表型推断
23783028 GOA
acts upstream of or within protein import into nucleus IDA
IDA: 通过直接分析推断
15964792 GOA
involved in protein import into nucleus IDA
IDA: 通过直接分析推断
7615630 GOA
involved in protein import into nucleus IMP
IMP: 通过突变表型推断
17209048 GOA
involved in ribosomal protein import into nucleus IDA
IDA: 通过直接分析推断
9687515 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NLS-dependent protein nuclear import complex IPI
IPI: 通过物理相互作用推断
10353244 GOA
is active in cytoplasm IDA
IDA: 通过直接分析推断
11891849 GOA
located in endoplasmic reticulum tubular network IDA
IDA: 通过直接分析推断
22701565 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
22701565 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
9670026 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KPNB1 蛋白结构

IBN_N

IBN_N: Importin-beta N-terminal domain (21 - 100)

HEAT_EZ

HEAT_EZ: HEAT-like repeat (380 - 435)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 876 a.a.
蛋白主名 其他名称

importin subunit beta-1

PTAC97

KPNB1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
KPNB1 Q14974 P2RY6 Homo sapiens Q15077
Pull Down
30833792
种属内
KPNB1 Q14974 SMNDC1 Homo sapiens O75940
Pull Down
15494309
种属间
KPNB1 Q14974 NSP1 Saccharomyces cerevisiae P14907
X-Ray Diffraction
12372823
种属间
KPNB1 Q14974 NSP1 Saccharomyces cerevisiae P14907
Competition Binding
19680228
种属内
KPNB1 Q14974 KPNA7 Homo sapiens A9QM74
Pull Down
20701745
种属内
KPNB1 Q14974 SLC15A3 Homo sapiens F5H1C8
Pull Down
30833792
种属内
KPNB1 Q14974 CD74 Homo sapiens P04233
Pull Down
30833792
种属内
KPNB1 Q14974 NUP153 Homo sapiens P49790
Phage Display
35044719
种属内
KPNB1 Q14974 NUP153 Homo sapiens P49790
Anti Tag CoIP
35271311
种属内
KPNB1 Q14974 NUP153 Homo sapiens P49790
FPS
35044719
种属内
KPNB1 Q14974 NUP153 Homo sapiens P49790
Anti Tag CoIP
26496610
种属内
KPNB1 Q14974 KPNA2 Homo sapiens P52292
Anti Tag CoIP
17596301
种属内
KPNB1 Q14974 KPNA2 Homo sapiens P52292
Anti Tag CoIP
35271311
种属内
KPNB1 Q14974 KPNA2 Homo sapiens P52292
Affinity Chrom
9405152
种属内
KPNB1 Q14974 KPNA2 Homo sapiens P52292
Anti Tag CoIP
26496610
种属内
KPNB1 Q14974 KPNA2 Homo sapiens P52292
Pull Down
20701745
种属内
KPNB1 Q14974 KPNA2 Homo sapiens P52292
SPR
10523667
种属内
KPNB1 Q14974 MAP3K14 Homo sapiens Q99558
Pull Down
30833792
种属内
KPNB1 Q14974 KPNA3 Homo sapiens O00505
Anti Tag CoIP
35271311
种属内
KPNB1 Q14974 KPNA3 Homo sapiens O00505
SPR
10523667
种属内
KPNB1 Q14974 KPNA3 Homo sapiens O00505
Anti Tag CoIP
26496610
种属内
KPNB1 Q14974 KPNA1 Homo sapiens P52294
Anti Tag CoIP
26496610
种属内
KPNB1 Q14974 KPNA1 Homo sapiens P52294
SPR
10523667
种属内
KPNB1 Q14974 KPNA1 Homo sapiens P52294
Anti Tag CoIP
35271311
种属内
KPNB1 Q14974 KPNA6 Homo sapiens O60684
Anti Tag CoIP
26496610
种属内
KPNB1 Q14974 KPNA6 Homo sapiens O60684
Anti Tag CoIP
35271311
种属内
KPNB1 Q14974 KPNA6 Homo sapiens O60684
SPR
10523667
种属内
KPNB1 Q14974 SMN1 Homo sapiens Q16637-3
CoIP
15494309
种属内
KPNB1 Q14974 SMN1 Homo sapiens Q16637-3
Pull Down
15494309
种属内
KPNB1 Q14974 KPNA4 Homo sapiens O00629
Anti Tag CoIP
26496610
种属内
KPNB1 Q14974 KPNA4 Homo sapiens O00629
Anti Tag CoIP
35271311
种属内
KPNB1 Q14974 KPNA4 Homo sapiens O00629
Pull Down
20818336
种属内
KPNB1 Q14974 KPNA4 Homo sapiens O00629
SPR
10523667
种属内
KPNB1 Q14974 UNC93B1 Homo sapiens Q9H1C4
Pull Down
30833792
种属内
KPNB1 Q14974 TNFSF13B Homo sapiens Q9Y275
Pull Down
30833792
种属内
KPNB1 Q14974 ERBB2 Homo sapiens P04626
Anti Bait CoIP
16314522
种属间
KPNB1 Q14974 L2 Human papillomavirus P03107
Pull Down
15507604
种属间
KPNB1 Q14974 L1 Human papillomavirus P03101
Pull Down
11971900
种属间
KPNB1 Q14974 L1 Human papillomavirus P03101
Pull Down
15507604
种属间
KPNB1 Q14974 Mrtfa Mus musculus Q8K4J6
Pull Down
20818336
种属间
KPNB1 Q14974 rev Human immunodeficiency virus P04620
Affinity Chrom
9405152
种属间
KPNB1 Q14974 rev Human immunodeficiency virus P04620
Pull Down
9405152
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 KPNB1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70837 KPNB1 Protein, Human (His) Q14974-1 (M1-A876) ≥95%

关联疾病

疾病名称 别名
Venezuelan Equine Encephalitis

Venezuelan Equine Fever

Venezuelan Equine Encephalomyelitis

Encephalitis Venezuelan Equine

Encephalomyelitis, Venezuelan Equine

Venezuelan Encephalitis

Disorder Due To Venezuelan Equine Encephalitis Virus

Venezuelan Equine Encephalitis Virus Infection

Venezuelan Equine Encephalomyelitis Virus Disease
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis
Campomelic Dysplasia

Acampomelic Campomelic Dysplasia

Camptomelic Dysplasia

Campomelic Dysplasia With Autosomal Sex Reversal

Cmpd

CMD1

Cmpd1

Cmpd1/Sra1

Acampomelic Campomelic Dysplasia With Autosomal Sex Reversal

Campomelic Dwarfism

Campomelic Syndrome

Dysplasia, Campomelic

Chronic Myeloproliferative Disorder

Familial Dilated Cardiomyopathy
Spinal Muscular Atrophy

Sma

5q Sma

Proximal Sma

Sma-Associated Sma

Spinal Amyotrophies

Spinal Amyotrophy

Spinal Muscle Degeneration

Spinal Muscle Wasting

Muscular Atrophy Spinal

Atrophy, Muscular, Spinal

Hereditary Motor Neuronopathy

Progressive Muscular Atrophy

Sma - [Spinal Muscular Atrophy]
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07422 KPNB1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris KPNB1 VGNC VGNC:42506
Bos taurus KPNB1 VGNC VGNC:30707
Mus musculus KPNB1 MGD MGI:107532
Macaca mulatta KPNB1 VGNC VGNC:74203
Felis catus KPNB1 VGNC VGNC:67979
Rattus norvegicus KPNB1 RGD RGD:2909
Others KPNB1 NCBI
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