2. Gene
  3. App - amyloid beta precursor protein Gene

App - amyloid beta precursor protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：淀粉样 β 前体蛋白

种属: Rattus norvegicus

同用名: Abeta

基因 ID: 54226 | 基因类型: protein coding

关于 App

Primary_assembly 11: 24,019,778-24,236,561 reverse strand.mRatBN7.2:CM026984.1

This gene has 3 transcripts (splice variants), 280 orthologues, 2 paralogues and is associated with 50 phenotypes. Biased expression in Kidney (RPKM 196.2), Lung (RPKM 1647.7) and 9 other tissues.

功能概要

该基因编码的蛋白可启动生长因子受体结合活性和肽酶激活剂活性。参与多个过程，包括细胞对金属离子的反应；对其他生物体的防御反应；和 MAPK 级联的正调控。位于几种细胞成分中，包括星形胶质细胞投射；轴突；和粗面内质网。用于研究阿尔茨海默病。阿尔茨海默病的生物标志物；糖尿病脑病;高血压;缺铁性贫血;和大脑中动脉梗塞。该基因的人类直系同源物与 APP 相关的脑淀粉样血管病有关；阿尔茨海默氏病;阿尔茨海默病 1；认知障碍;和视觉性癫痫。与人类 APP（淀粉样蛋白前体蛋白）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables growth factor receptor binding activity and peptidase activator activity. Involved in several processes, including cellular response to metal ion; defense response to Other organism; and positive regulation of MAPK cascade. Located in several cellular components, including astrocyte projection; axon; and rough endoplasmic reticulum. Used to study Alzheimer's disease. Biomarker of Alzheimer's disease; diabetic encephalopathy; hypertension; iron deficiency anemia; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Apr 2022]

App 基因产物(1)

mRNA Protein Name
NM_019288.2 NP_062161.1 amyloid-beta precursor protein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables growth factor receptor binding IPI
IPI: 通过物理相互作用推断
19334058 RGD
enables peptidase activator activity IDA
IDA: 通过直接分析推断
12493564 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9461550 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antibacterial humoral response IDA
IDA: 通过直接分析推断
20209079 RGD
involved in antifungal humoral response IDA
IDA: 通过直接分析推断
20209079 RGD
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: 通过直接分析推断
20209079 RGD
involved in cellular response to cAMP IEP
IEP: 通过表达模式推断
9144253 RGD
involved in cellular response to copper ion IEP
IEP: 通过表达模式推断
18583042 RGD
involved in cellular response to manganese ion IEP
IEP: 通过表达模式推断
18583042 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: 通过表达模式推断
10821917 RGD
involved in cellular response to norepinephrine stimulus IMP
IMP: 通过突变表型推断
9144253 RGD
involved in defense response to Gram-negative bacterium IDA
IDA: 通过直接分析推断
20209079 RGD
involved in defense response to Gram-positive bacterium IDA
IDA: 通过直接分析推断
20209079 RGD
involved in innate immune response IDA
IDA: 通过直接分析推断
20209079 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
11404397 RGD
involved in positive regulation of ERK1 and ERK2 cascade IGI
IGI: 通过遗传相互作用推断
11404397 RGD
involved in positive regulation of protein metabolic process IDA
IDA: 通过直接分析推断
11404397 RGD
involved in regulation of response to calcium ion IGI
IGI: 通过遗传相互作用推断
11404397 RGD
involved in response to interleukin-1 IDA
IDA: 通过直接分析推断
20395292 RGD
involved in response to lead ion IEP
IEP: 通过表达模式推断
16230335 RGD
involved in response to yeast IDA
IDA: 通过直接分析推断
20209079 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in astrocyte projection IDA
IDA: 通过直接分析推断
8097074 RGD
located in axon IDA
IDA: 通过直接分析推断
8987743 RGD
located in cell surface IDA
IDA: 通过直接分析推断
8987743 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
14615045 RGD
located in growth cone IDA
IDA: 通过直接分析推断
12843239 RGD
located in growth cone filopodium IDA
IDA: 通过直接分析推断
12843239 RGD
located in growth cone lamellipodium IDA
IDA: 通过直接分析推断
12843239 RGD
located in main axon IDA
IDA: 通过直接分析推断
12843239 RGD
is active in neuronal dense core vesicle IDA
IDA: 通过直接分析推断
29577889 RGD
NOT located in synaptic vesicle IDA
IDA: 通过直接分析推断
8987743 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

App 蛋白结构

A4_EXTRA

A4_EXTRA: smart00006 (23 - 187)

Kunitz_ABPP-like

Kunitz_ABPP-like: cd22607 (293 - 340)

APP_E2

APP_E2: pfam12925 (365 - 547)

JMTM_Notch_APP

JMTM_Notch_APP: cl41775 (692 - 766)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
蛋白主名 其他名称

amyloid-beta precursor protein

amyloid-beta A4 protein

ABPP

AG

alzheimer disease amyloid A4 protein homolog

alzheimer disease amyloid protein

amyloid A4

amyloid beta (A4) precursor protein

amyloid beta A4 protein

amyloid precursor protein

amyloidogenic glycoprotein

beta-amyloid precursor protein

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-N0192 Arbutin Inhibitor 99.76% 否
HY-14537 Latrepirdine dihydrochloride 99.65% 是
HY-14862 Latrepirdine / 否
Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-103374 Phenserine Inhibitor 99.55% Phase 3
HY-10254 Mirdametinib 99.95% Phase 2
HY-50759 Ispinesib 99.62% Phase 2
HY-106005 MMV390048 Inhibitor 99.17% Phase 2
HY-19846 VRX-03011 Agonist / Phase 2
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99185 Bapineuzumab 96.62% Phase 3
HY-P990078 Remternetug Inhibitor 96% Phase 3
Pre-clinical Phase
生物活性分子 (78)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103490 Takinib 98.92% 否
HY-139214 IXA4 Inhibitor 98.83% 否
HY-N1472 Levistolide A 99.26% 否
HY-19369 L-685458 99.37% 否
HY-16009 Buntanetap Inhibitor 99.71% 否
HY-12856 GSK503 Inhibitor 99.52% 否
HY-135699 TD52 ≥95.0% 否
HY-114174 Fmoc-Ala-Glu-Asn-Lys-NH2 99.13% 否
HY-124322 NB-360 Inhibitor 99.22% 否
HY-108643 CMPD1 Inhibitor 99.86% 否
HY-129096 IDT307 99.76% 否
HY-123960A Raphin1 acetate Inhibitor 99.93% 否
HY-124832 δ-Secretase inhibitor 11 Inhibitor 99.06% 否
HY-123960 Raphin1 Inhibitor 99.75% 否
HY-18010 PCI 29732 Inhibitor 99.86% 否
HY-12989 LDN-91946 Inhibitor 98.70% 否
HY-15294 CZC24832 Inhibitor 99.07% 否
HY-18292 ARN2966 Inhibitor 99.87% 否
HY-138962 κ-Carrageenan Inducer / 否
HY-50883 BMS 299897 Inhibitor 99.64% 否
HY-136499 DI-82 98.76% 否
HY-153986 AEP-IN-2 99.13% 否
HY-126242S Tyk2-IN-7 Inhibitor 99.62% 否
HY-120597 SAK3 Activator 99.80% 否
HY-161110 APP degrader-1 Degrader 98.35% 否
HY-50882 ELN318463 Inhibitor 99.45% 否
HY-135699A TD52 dihydrochloride 99.90% 否
HY-139973 OAB-14 98.72% 否
HY-145286 IMPDH2-IN-2 99.73% 否
HY-117924 AUTEN-67 Inducer ≥92.0% 否
HY-19918A Anatabine dicitrate 99.03% 否
HY-108966 Kushenol C Inhibitor 99.58% 否
HY-16009B Buntanetap L-Tartrate 98.93% 否
HY-131068 BACE-1 inhibitor 2 Inhibitor / 否
HY-128585 GNE684 Inhibitor / 否
HY-P2551 Biotin-β-Amyloid (17-40) / 否
HY-103374A Phenserine tartrate Inhibitor / 否
HY-103538 JLK-6 Inhibitor / 否
HY-105940 IQB-782 / 否
HY-107164 Thiomarinol A Inhibitor / 否
HY-118243 KMS88009 Inhibitor / 否
HY-118245 APP-FUBINACA Agonist / 否
HY-126047B (R)-(+)-Anatabine / 否
HY-128464 LL320 / 否
HY-135618 DHODH-IN-3 Inhibitor / 否
HY-136733 Ac-DNLD-CHO Inhibitor / 否
HY-144739 BACE1-IN-8 Inhibitor / 否
HY-144741 BACE1-IN-9 Inhibitor / 否
HY-147672 IleRS-IN-1 Inhibitor / 否
HY-147674 Isoleucyl tRNA synthetase-IN-2 Inhibitor / 否
HY-149396 FXIIa-IN-1 Inhibitor / 否
HY-161109 Aβ42-IN-4 / 否
HY-161953 O-GlcNAcase-IN-2 Inhibitor / 否
HY-168241 Flucopride / 否
HY-N12249 7-Deoxy-trans-dihydronarciclasine Inhibitor / 否
HY-P10163 α-Secretase Substrate II, Fluorogenic / 否
HY-P10180 β-Amyloid/A4 Protein Precusor (319-335) / 否
HY-P10247 Amyloid precursor C-terminal peptide / 否
HY-P10487 APP669-711 / 否
HY-P1378 β-Amyloid (1-43)(human) / 否
HY-P1378A β-Amyloid (1-43)(human) TFA / 否
HY-P1894 β-Amyloid Protein Precursor 770 (135-155) / 否
HY-P3779 Amyloid 17-42 Inducer / 否
HY-P4553 H-Met-Pro-OH / 否
HY-P4919 Mca-SEVNLDAEFK(Dnp) / 否
HY-P4926 Mca-SEVKMDAEFRK(Dnp)RR-NH2 / 否
HY-P5331 [Asn23]-beta-Amyloid (1-42), iowa mutation / 否
HY-P5365 [Asn23] β-Amyloid (1-40), Iowa mutation / 否
HY-P6365B APP-018 / 否
HY-RS00863 APP Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00864 App Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00865 App Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-128090 Apstatin Inhibitor / 否
HY-149397 FXIIa-IN-2 Inhibitor / 否
HY-50882A ELN318463 racemate Inhibitor / 否
HY-N1414A 3′,6-Disinapoylsucrose Inhibitor / 否
HY-P4885 Glp-amyloid-β (3-40) peptide (human) / 否
HY-P1729 M-2420 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens App NCBI NCBI:351
Mus musculus App NCBI NCBI:11820
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