2. Gene
  3. App - amyloid beta (A4) precursor protein Gene

App - amyloid beta (A4) precursor protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：淀粉样蛋白 (A4) 前体蛋白

种属: Mus musculus

同用名: Ag; Abpp; Adap; Cvap; Abeta; betaApp; E030013M08Rik

基因 ID: 11820 | 基因类型: protein coding

关于 App

Chromosome 16: 84,746,573-84,970,654 reverse strand.GRCm39:CM001009.3

This gene has 11 transcripts (splice variants), 280 orthologues, 2 paralogues and is associated with 62 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 142.7), lung adult (RPKM 135.8) and 25 other tissues.

功能概要

该基因编码的蛋白可启动 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性；低密度脂蛋白颗粒受体结合活性；和信号受体激活剂活性。参与血液循环的负调节；内皮素生产的积极调节；和肿瘤坏死因子产生的正调节。作用于多个过程的上游或内部，包括细胞金属离子稳态；神经系统发育；和调节细胞蛋白质代谢过程。位于几种细胞成分中，包括细胞质囊泡；细胞骨架；和神经肌肉接头。是膜的组成部分。以多种结构表达，包括消化系统；泌尿生殖系统；神经系统;神经源性基板；和感觉器官。用于研究阿尔茨海默病。该基因的人类直系同源物与 APP 相关的脑淀粉样血管病有关；阿尔茨海默氏病;阿尔茨海默病 1；认知障碍;和视觉性癫痫。与人类 APP（淀粉样蛋白前体蛋白）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; low-density lipoprotein particle receptor binding activity; and signaling receptor activator activity. Involved in negative regulation of blood circulation; positive regulation of endothelin production; and positive regulation of tumor necrosis factor production. Acts upstream of or within several processes, including cellular metal ion homeostasis; nervous system development; and regulation of cellular protein metabolic process. Located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and neuromuscular junction. Is integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; neurogenic placode; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Apr 2022]

App 基因产物(5)

mRNA Protein Name
NM_001198826.1 NP_001185755.1 amyloid-beta precursor protein isoform 6 precursor
NM_007471.3 NP_031497.2 amyloid-beta precursor protein isoform 2 precursor
NM_001198824.1 NP_001185753.1 amyloid-beta precursor protein isoform 3 precursor
NM_001198825.1 NP_001185754.1 amyloid-beta precursor protein isoform 5 precursor
NM_001198823.1 NP_001185752.1 amyloid-beta precursor protein isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
15944124 MGI
enables low-density lipoprotein particle receptor binding IPI
IPI: 通过物理相互作用推断
22383525 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10460257 MGI
enables protein domain specific binding IDA
IDA: 通过直接分析推断
30902970 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
24305806 MGI
enables signaling receptor activator activity IDA
IDA: 通过直接分析推断
11316806 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of G2/M transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
15561424 MGI
acts upstream of or within adult locomotory behavior IMP
IMP: 通过突变表型推断
7758106 MGI
acts upstream of or within axo-dendritic transport IGI
IGI: 通过遗传相互作用推断
20829454 MGI
NOT acts upstream of or within axo-dendritic transport IMP
IMP: 通过突变表型推断
15745965 MGI
acts upstream of or within axo-dendritic transport IMP
IMP: 通过突变表型推断
11740561 MGI
acts upstream of or within axon midline choice point recognition IMP
IMP: 通过突变表型推断
8001115 MGI
acts upstream of or within axonogenesis IMP
IMP: 通过突变表型推断
9390996 MGI
acts upstream of or within cholesterol metabolic process IGI
IGI: 通过遗传相互作用推断
17920016 MGI
acts upstream of or within cholesterol metabolic process IMP
IMP: 通过突变表型推断
17920016 MGI
acts upstream of or within cognition IDA
IDA: 通过直接分析推断
25592972 MGI
acts upstream of or within collateral sprouting in absence of injury IGI
IGI: 通过遗传相互作用推断
15689559 MGI
acts upstream of or within cytosolic mRNA polyadenylation IDA
IDA: 通过直接分析推断
16314516 MGI
acts upstream of or within dendrite development IGI
IGI: 通过遗传相互作用推断
15689559 MGI
acts upstream of or within dendrite development IMP
IMP: 通过突变表型推断
9390996 MGI
acts upstream of or within endocytosis IMP
IMP: 通过突变表型推断
16025111 MGI
acts upstream of or within extracellular matrix organization IGI
IGI: 通过遗传相互作用推断
15385965 MGI
acts upstream of or within forebrain development IGI
IGI: 通过遗传相互作用推断
15385965 MGI
acts upstream of or within forebrain development IMP
IMP: 通过突变表型推断
8001115 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
30902970 MGI
acts upstream of or within intracellular copper ion homeostasis IGI
IGI: 通过遗传相互作用推断
15447675 MGI
acts upstream of or within intracellular copper ion homeostasis IMP
IMP: 通过突变表型推断
10526140 MGI
acts upstream of or within ionotropic glutamate receptor signaling pathway IMP
IMP: 通过突变表型推断
16025111 MGI
acts upstream of or within locomotory behavior IGI
IGI: 通过遗传相互作用推断
9461064 MGI
acts upstream of or within mating behavior IGI
IGI: 通过遗传相互作用推断
9461064 MGI
acts upstream of mitotic cell cycle IMP
IMP: 通过突变表型推断
15561424 MGI
involved in negative regulation of blood circulation IGI
IGI: 通过遗传相互作用推断
12808450 MGI
acts upstream of or within negative regulation of neuron differentiation IDA
IDA: 通过直接分析推断
18278038 MGI
acts upstream of or within negative regulation of neuron differentiation IGI
IGI: 通过遗传相互作用推断
18278038 MGI
acts upstream of or within negative regulation of presynapse assembly IMP
IMP: 通过突变表型推断
30902970 MGI
acts upstream of or within neuromuscular process controlling balance IGI
IGI: 通过遗传相互作用推断
9461064 MGI
acts upstream of or within neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
16478525 MGI
acts upstream of or within neuron cellular homeostasis IGI
IGI: 通过遗传相互作用推断
12431992 MGI
acts upstream of neuron differentiation IDA
IDA: 通过直接分析推断
18278038 MGI
acts upstream of neuron differentiation IGI
IGI: 通过遗传相互作用推断
18278038 MGI
acts upstream of or within neuron projection development IDA
IDA: 通过直接分析推断
8083748 MGI
acts upstream of or within neuron remodeling IMP
IMP: 通过突变表型推断
10219973 MGI
acts upstream of or within positive regulation of G2/M transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
15561424 MGI
involved in positive regulation of endothelin production IGI
IGI: 通过遗传相互作用推断
12808450 MGI
acts upstream of or within positive regulation of mitotic cell cycle IMP
IMP: 通过突变表型推断
15561424 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15944124 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15944124 MGI
involved in positive regulation of tumor necrosis factor production IGI
IGI: 通过遗传相互作用推断
12808450 MGI
acts upstream of or within protein phosphorylation IMP
IMP: 通过突变表型推断
16025111 MGI
acts upstream of or within regulation of epidermal growth factor-activated receptor activity IGI
IGI: 通过遗传相互作用推断
17556541 MGI
acts upstream of or within regulation of gene expression IDA
IDA: 通过直接分析推断
12074840 MGI
acts upstream of or within regulation of multicellular organism growth IMP
IMP: 通过突变表型推断
9754878 MGI
acts upstream of or within regulation of protein binding IGI
IGI: 通过遗传相互作用推断
17920016 MGI
acts upstream of or within regulation of protein binding IMP
IMP: 通过突变表型推断
17920016 MGI
acts upstream of or within regulation of synapse structure or activity IMP
IMP: 通过突变表型推断
10219973 MGI
acts upstream of or within regulation of translation IDA
IDA: 通过直接分析推断
16314516 MGI
acts upstream of or within response to oxidative stress IGI
IGI: 通过遗传相互作用推断
16478525 MGI
acts upstream of or within smooth endoplasmic reticulum calcium ion homeostasis IGI
IGI: 通过遗传相互作用推断
12431992 MGI
acts upstream of or within suckling behavior IGI
IGI: 通过遗传相互作用推断
9461064 MGI
acts upstream of or within synaptic assembly at neuromuscular junction IGI
IGI: 通过遗传相互作用推断
15689559 MGI
acts upstream of or within visual learning IMP
IMP: 通过突变表型推断
10338291 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in COPII-coated ER to Golgi transport vesicle IDA
IDA: 通过直接分析推断
19966784 MGI
located in Golgi apparatus IDA
IDA: 通过直接分析推断
16018997 MGI
located in Golgi-associated vesicle IDA
IDA: 通过直接分析推断
23931995 MGI
located in apical part of cell IDA
IDA: 通过直接分析推断
15561424 MGI
located in axon IDA
IDA: 通过直接分析推断
11740561 MGI
is active in axon IMP
IMP: 通过突变表型推断
30902970 MGI
is active in cell surface IDA
IDA: 通过直接分析推断
30902970 MGI
located in cell surface IDA
IDA: 通过直接分析推断
16227578 MGI
located in cell-cell junction IDA
IDA: 通过直接分析推断
23793062 MGI
located in ciliary rootlet IDA
IDA: 通过直接分析推断
16018997 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
10845772 MGI
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
11740561 MGI
located in early endosome IDA
IDA: 通过直接分析推断
25592972 MGI
is active in intracellular vesicle IDA
IDA: 通过直接分析推断
30902970 MGI
located in membrane IDA
IDA: 通过直接分析推断
9535056 MGI
located in neuromuscular junction IDA
IDA: 通过直接分析推断
10845772 MGI
located in neuron projection IDA
IDA: 通过直接分析推断
16301330 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
8207383 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
15009636 MGI
is active in presynaptic active zone IDA
IDA: 通过直接分析推断
23815291 MGI
is active in presynaptic active zone IEP
IEP: 通过表达模式推断
23815291 MGI
located in recycling endosome IDA
IDA: 通过直接分析推断
23931995 MGI
located in spindle midzone IDA
IDA: 通过直接分析推断
15561424 MGI
located in synaptic vesicle IDA
IDA: 通过直接分析推断
25438880 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

App 蛋白结构

A4_EXTRA

A4_EXTRA: smart00006 (23 - 187)

Kunitz_ABPP-like

Kunitz_ABPP-like: cd22607 (293 - 340)

APP_E2

APP_E2: pfam12925 (365 - 547)

JMTM_Notch_APP

JMTM_Notch_APP: cl41775 (692 - 766)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
蛋白主名 其他名称

amyloid-beta precursor protein

amyloid-beta A4 protein

alzheimer disease amyloid A4 protein homolog

alzheimer disease amyloid protein

amyloid beta A4 protein

amyloid precursor protein

amyloidogenic glycoprotein

appican

beta-amyloid precursor protein

protease nexin II

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-N0192 Arbutin Inhibitor 99.76% 否
HY-14537 Latrepirdine dihydrochloride 99.65% 是
HY-14862 Latrepirdine / 否
Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-103374 Phenserine Inhibitor 99.55% Phase 3
HY-10254 Mirdametinib 99.95% Phase 2
HY-50759 Ispinesib 99.62% Phase 2
HY-106005 MMV390048 Inhibitor 99.17% Phase 2
HY-19846 VRX-03011 Agonist / Phase 2
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99185 Bapineuzumab 96.62% Phase 3
HY-P990078 Remternetug Inhibitor 96% Phase 3
Pre-clinical Phase
生物活性分子 (78)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103490 Takinib 98.92% 否
HY-139214 IXA4 Inhibitor 98.83% 否
HY-N1472 Levistolide A 99.26% 否
HY-19369 L-685458 99.37% 否
HY-16009 Buntanetap Inhibitor 99.71% 否
HY-12856 GSK503 Inhibitor 99.52% 否
HY-135699 TD52 ≥95.0% 否
HY-114174 Fmoc-Ala-Glu-Asn-Lys-NH2 99.13% 否
HY-124322 NB-360 Inhibitor 99.22% 否
HY-108643 CMPD1 Inhibitor 99.86% 否
HY-129096 IDT307 99.76% 否
HY-123960A Raphin1 acetate Inhibitor 99.93% 否
HY-124832 δ-Secretase inhibitor 11 Inhibitor 99.06% 否
HY-123960 Raphin1 Inhibitor 99.75% 否
HY-18010 PCI 29732 Inhibitor 99.86% 否
HY-12989 LDN-91946 Inhibitor 98.70% 否
HY-15294 CZC24832 Inhibitor 99.07% 否
HY-18292 ARN2966 Inhibitor 99.87% 否
HY-138962 κ-Carrageenan Inducer / 否
HY-50883 BMS 299897 Inhibitor 99.64% 否
HY-136499 DI-82 98.76% 否
HY-153986 AEP-IN-2 99.13% 否
HY-126242S Tyk2-IN-7 Inhibitor 99.62% 否
HY-120597 SAK3 Activator 99.80% 否
HY-161110 APP degrader-1 Degrader 98.35% 否
HY-50882 ELN318463 Inhibitor 99.45% 否
HY-135699A TD52 dihydrochloride 99.90% 否
HY-139973 OAB-14 98.72% 否
HY-145286 IMPDH2-IN-2 99.73% 否
HY-117924 AUTEN-67 Inducer ≥92.0% 否
HY-19918A Anatabine dicitrate 99.03% 否
HY-108966 Kushenol C Inhibitor 99.58% 否
HY-16009B Buntanetap L-Tartrate 98.93% 否
HY-131068 BACE-1 inhibitor 2 Inhibitor / 否
HY-128585 GNE684 Inhibitor / 否
HY-P2551 Biotin-β-Amyloid (17-40) / 否
HY-103374A Phenserine tartrate Inhibitor / 否
HY-103538 JLK-6 Inhibitor / 否
HY-105940 IQB-782 / 否
HY-107164 Thiomarinol A Inhibitor / 否
HY-118243 KMS88009 Inhibitor / 否
HY-118245 APP-FUBINACA Agonist / 否
HY-126047B (R)-(+)-Anatabine / 否
HY-128464 LL320 / 否
HY-135618 DHODH-IN-3 Inhibitor / 否
HY-136733 Ac-DNLD-CHO Inhibitor / 否
HY-144739 BACE1-IN-8 Inhibitor / 否
HY-144741 BACE1-IN-9 Inhibitor / 否
HY-147672 IleRS-IN-1 Inhibitor / 否
HY-147674 Isoleucyl tRNA synthetase-IN-2 Inhibitor / 否
HY-149396 FXIIa-IN-1 Inhibitor / 否
HY-161109 Aβ42-IN-4 / 否
HY-161953 O-GlcNAcase-IN-2 Inhibitor / 否
HY-168241 Flucopride / 否
HY-N12249 7-Deoxy-trans-dihydronarciclasine Inhibitor / 否
HY-P10163 α-Secretase Substrate II, Fluorogenic / 否
HY-P10180 β-Amyloid/A4 Protein Precusor (319-335) / 否
HY-P10247 Amyloid precursor C-terminal peptide / 否
HY-P10487 APP669-711 / 否
HY-P1378 β-Amyloid (1-43)(human) / 否
HY-P1378A β-Amyloid (1-43)(human) TFA / 否
HY-P1894 β-Amyloid Protein Precursor 770 (135-155) / 否
HY-P3779 Amyloid 17-42 Inducer / 否
HY-P4553 H-Met-Pro-OH / 否
HY-P4919 Mca-SEVNLDAEFK(Dnp) / 否
HY-P4926 Mca-SEVKMDAEFRK(Dnp)RR-NH2 / 否
HY-P5331 [Asn23]-beta-Amyloid (1-42), iowa mutation / 否
HY-P5365 [Asn23] β-Amyloid (1-40), Iowa mutation / 否
HY-P6365B APP-018 / 否
HY-RS00863 APP Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00864 App Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00865 App Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-128090 Apstatin Inhibitor / 否
HY-149397 FXIIa-IN-2 Inhibitor / 否
HY-50882A ELN318463 racemate Inhibitor / 否
HY-N1414A 3′,6-Disinapoylsucrose Inhibitor / 否
HY-P4885 Glp-amyloid-β (3-40) peptide (human) / 否
HY-P1729 M-2420 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens App NCBI NCBI:351
Rattus norvegicus App NCBI NCBI:54226
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