1. Gene
  2. PPP1CC - protein phosphatase 1 catalytic subunit gamma Gene

PPP1CC - protein phosphatase 1 catalytic subunit gamma Gene

中文名称:蛋白磷酸酶 1 催化亚基 γ

种属: Homo sapiens

同用名: PP1C; PP-1G; PPP1G

基因 ID: 5501 | 基因类型: protein coding

关于 PPP1CC

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:110,708,376-110,742,891 (from NCBI)

This gene has 11 transcripts (splice variants), 231 orthologues and 12 paralogues. Ubiquitous expression in duodenum (RPKM 77.6), small intestine (RPKM 62.4) and 25 other tissues.

功能概要

该基因编码的蛋白质属于蛋白磷酸酶家族 PP1 亚家族。 PP1 是一种普遍存在的丝氨酸/苏氨酸磷酸酶,可调节许多细胞过程,包括细胞分裂。它在哺乳动物细胞中表达为三种密切相关的亚型,α、β/δ 和γ,它们具有不同的定位模式。该基因编码 γ 同工酶。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供,2011 年 10 月]

The protein encoded by this gene belongs to the protein Phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine Phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

PPP1CC 基因产物(2)

mRNA Protein Name
NM_001244974.2 NP_001231903.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 2
NM_002710.4 NP_002701.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1

PPP1CC 蛋白结构

Metallophos

Metallophos: Calcineurin-like phosphoesterase (59 - 250)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase PP1-gamma catalytic subunit

protein phosphatase 1, catalytic subunit, gamma isozyme

PPP1CC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PPP1CC P36873 KNL1 Homo sapiens Q8NG31
Anti Tag CoIP
33961781
种属内
PPP1CC P36873 TP53BP2 Homo sapiens Q13625-3
Y2H Prey Pooling
25416956
种属内
PPP1CC P36873 TP53BP2 Homo sapiens Q13625-3
Validated Y2H
25416956
种属内
PPP1CC P36873 TP53BP2 Homo sapiens Q13625-3
Y2H Array
25416956
种属内
PPP1CC P36873 PPP1R7 Homo sapiens Q15435
Anti Tag CoIP
24366813
种属内
PPP1CC P36873 PPP1R7 Homo sapiens Q15435
Anti Tag CoIP
33961781
种属内
PPP1CC P36873 PPP1R7 Homo sapiens Q15435
Y2H Fragment Pooling
23414517
种属内
PPP1CC P36873 PPP1R7 Homo sapiens Q15435
BioID
28330616
种属内
PPP1CC P36873 PPP1R7 Homo sapiens Q15435
Pull Down
28330616
种属内
PPP1CC P36873 PPP1R2B Homo sapiens Q6NXS1
Validated Y2H
32296183
种属内
PPP1CC P36873 PPP1R11 Homo sapiens O60927
Anti Tag CoIP
33961781
种属内
PPP1CC P36873 PPP1R11 Homo sapiens O60927
Anti Tag CoIP
24366813
种属内
PPP1CC P36873 PPP1R11 Homo sapiens O60927
BioID
28330616
种属内
PPP1CC P36873 PPP1R11 Homo sapiens O60927
Pull Down
28330616
种属内
PPP1CC P36873 PPP1R2 Homo sapiens P41236
BioID
28330616
种属内
PPP1CC P36873 PPP1R2 Homo sapiens P41236
Pull Down
28330616
种属内
PPP1CC P36873 PPP1R2 Homo sapiens P41236
Anti Tag CoIP
24366813
种属内
PPP1CC P36873 PPP1R2 Homo sapiens P41236
Anti Tag CoIP
12761178
种属内
PPP1CC P36873 PPP1R2 Homo sapiens P41236
Anti Tag CoIP
33961781
种属内
PPP1CC P36873 PPP1R2 Homo sapiens P41236
Anti Tag CoIP
26496610
种属内
PPP1CC P36873 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
种属内
PPP1CC P36873 TP53BP2 Homo sapiens Q05BL1
Validated Y2H
32296183
种属内
PPP1CC P36873 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
种属内
PPP1CC P36873 TPRN Homo sapiens Q4KMQ1-2
Validated Y2H
32296183
种属内
PPP1CC P36873 TPRN Homo sapiens Q4KMQ1-2
Y2H Array
32296183
种属内
PPP1CC P36873 TPRN Homo sapiens Q4KMQ1-2
Y2H Prey Pooling
32296183
种属内
PPP1CC P36873 SAXO4 Homo sapiens Q7Z5V6-2
Validated Y2H
32296183
种属内
PPP1CC P36873 NRAC Homo sapiens Q8N912
Validated Y2H
32296183
种属内
PPP1CC P36873 PPP1R8 Homo sapiens Q12972-2
Y2H Prey Pooling
32296183
种属内
PPP1CC P36873 PPP1R8 Homo sapiens Q12972-2
Validated Y2H
32296183
种属内
PPP1CC P36873 PPP1R8 Homo sapiens Q12972-2
Y2H Array
32296183
种属内
PPP1CC P36873 URI1 Homo sapiens O94763-1
Anti Bait CoIP
27505673
种属内
PPP1CC P36873 AATK Homo sapiens Q6ZMQ8
Ub Reconstruction
28065597
种属内
PPP1CC P36873 LMTK2 Homo sapiens Q8IWU2
Anti Tag CoIP
33961781
种属内
PPP1CC P36873 LMTK2 Homo sapiens Q8IWU2
Anti Tag CoIP
24366813
种属内
PPP1CC P36873 LMTK2 Homo sapiens Q8IWU2
Ub Reconstruction
28065597
种属内
PPP1CC P36873 LMTK2 Homo sapiens Q8IWU2
BioID
28330616
种属内
PPP1CC P36873 LMTK2 Homo sapiens Q8IWU2
Pull Down
28330616
种属内
PPP1CC P36873 LMTK2 Homo sapiens Q8IWU2
Anti Tag CoIP
26496610
种属内
PPP1CC P36873 PPP1R3C Homo sapiens Q9UQK1
Y2H Prey Pooling
32296183
种属内
PPP1CC P36873 PPP1R3C Homo sapiens Q9UQK1
Validated Y2H
32296183
种属内
PPP1CC P36873 PPP1R3C Homo sapiens Q9UQK1
Y2H Array
32296183
种属内
PPP1CC P36873 PPP1R15B Homo sapiens Q5SWA1
BioID
28330616
种属内
PPP1CC P36873 PPP1R15B Homo sapiens Q5SWA1
Pull Down
28330616
种属内
PPP1CC P36873 PPP1R15B Homo sapiens Q5SWA1
Anti Tag CoIP
33961781
种属内
PPP1CC P36873 ZFYVE9 Homo sapiens O95405
Anti Tag CoIP
33961781
种属内
PPP1CC P36873 ZFYVE9 Homo sapiens O95405
Validated Y2H
25416956
种属内
PPP1CC P36873 ZFYVE9 Homo sapiens O95405
Y2H Prey Pooling
25416956
种属内
PPP1CC P36873 ZFYVE9 Homo sapiens O95405
Anti Tag CoIP
24366813
种属内
PPP1CC P36873 PPP1R9B Homo sapiens Q96SB3
Pull Down
28330616
种属内
PPP1CC P36873 PPP1R9B Homo sapiens Q96SB3
Anti Bait CoIP
25785436
种属内
PPP1CC P36873 PPP1R9B Homo sapiens Q96SB3
Anti Tag CoIP
33961781
种属内
PPP1CC P36873 PPP1R9B Homo sapiens Q96SB3
Anti Tag CoIP
24366813
种属内
PPP1CC P36873 PPP1R9B Homo sapiens Q96SB3
Anti Tag CoIP
26496610
种属内
PPP1CC P36873 PPP1R9B Homo sapiens Q96SB3
BioID
28330616
种属内
PPP1CC P36873 URI1 Homo sapiens O94763
Anti Bait CoIP
27505673
种属内
PPP1CC P36873 URI1 Homo sapiens O94763
Anti Tag CoIP
33961781
种属内
PPP1CC P36873 URI1 Homo sapiens O94763
Anti Tag CoIP
26496610
种属内
PPP1CC P36873 URI1 Homo sapiens O94763
Anti Bait CoIP
21397856
种属内
PPP1CC P36873 URI1 Homo sapiens O94763
Pull Down
28330616
种属内
PPP1CC P36873 URI1 Homo sapiens O94763
Anti Tag CoIP
24366813
种属内
PPP1CC P36873 URI1 Homo sapiens O94763
BioID
28330616
种属内
PPP1CC P36873 RRP1B Homo sapiens Q14684
Anti Tag CoIP
33961781
种属内
PPP1CC P36873 RRP1B Homo sapiens Q14684
Anti Tag CoIP
24366813
种属内
PPP1CC P36873 RRP1B Homo sapiens Q14684
IF
20926688
种属内
PPP1CC P36873 RRP1B Homo sapiens Q14684
BioID
28330616
种属内
PPP1CC P36873 RRP1B Homo sapiens Q14684
Pull Down
28330616
种属内
PPP1CC P36873 RRP1B Homo sapiens Q14684
Far-WB
20926688
种属内
PPP1CC P36873 PPP1R3B Homo sapiens Q86XI6
Validated Y2H
32296183
种属内
PPP1CC P36873 PPP1R3B Homo sapiens Q86XI6
Y2H Array
32296183
种属内
PPP1CC P36873 PPP1R3B Homo sapiens Q86XI6
Y2H Prey Pooling
32296183
种属内
PPP1CC P36873 CSRNP1 Homo sapiens Q96S65
Y2H Prey Pooling
25416956
种属内
PPP1CC P36873 CSRNP1 Homo sapiens Q96S65
Validated Y2H
25416956
种属内
PPP1CC P36873 CSRNP2 Homo sapiens Q9H175
Y2H Prey Pooling
32296183
种属内
PPP1CC P36873 CSRNP2 Homo sapiens Q9H175
Validated Y2H
32296183
种属内
PPP1CC P36873 CSRNP2 Homo sapiens Q9H175
Y2H Array
32296183
种属内
PPP1CC P36873 CSRNP2 Homo sapiens Q9H175
Anti Tag CoIP
33961781
种属内
PPP1CC P36873 CSRNP2 Homo sapiens Q9H175
Y2H Array
29892012
种属内
PPP1CC P36873 OGT Homo sapiens O15294
Anti Bait CoIP
27505673
种属内
PPP1CC P36873 PPP1R16A Homo sapiens Q96I34
Validated Y2H
32296183
种属内
PPP1CC P36873 CD2BP2 Homo sapiens O95400
Validated Y2H
25416956
种属内
PPP1CC P36873 CD2BP2 Homo sapiens O95400
Y2H Array
25416956
种属内
PPP1CC P36873 TP53BP2 Homo sapiens Q13625
Anti Tag CoIP
33961781
种属内
PPP1CC P36873 TP53BP2 Homo sapiens Q13625
Peptide Array
18448430
种属内
PPP1CC P36873 TP53BP2 Homo sapiens Q13625
Anti Tag CoIP
24366813
种属内
PPP1CC P36873 TP53BP2 Homo sapiens Q13625
BioID
28330616
种属内
PPP1CC P36873 TP53BP2 Homo sapiens Q13625
Pull Down
28330616
种属内
PPP1CC P36873 TP53BP2 Homo sapiens Q13625
Y2H
21988832
种属内
PPP1CC P36873 ESR1 Homo sapiens P03372
Antibody Array
17274640
种属间
PPP1CC P36873 Clock Mus musculus O08785
Anti Tag CoIP
23555304
种属内
PPP1CC P36873 ZNF629 Homo sapiens Q9UEG4
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PPP1CC 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71228 PPP1CC Protein, Human (His) P36873-1 (M1-K323) ≥95%

关联疾病

疾病名称 别名
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PPP1CC MGD MGI:104872
Rattus norvegicus PPP1CC RGD RGD:3377
Bos taurus PPP1CC VGNC VGNC:53916
Canis familiaris PPP1CC VGNC VGNC:52957
Felis catus PPP1CC VGNC VGNC:80466
Others PPP1CC NCBI